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Genetic evidence for PARP1 trapping as a driver of PARP inhibitor efficacy in BRCA mutant cancer cells PARP1捕获作为BRCA突变癌细胞中PARP抑制剂疗效驱动因素的遗传证据 Ribeiro, Jonathan; Hansen, Kjetil; Van beek, Lotte; Stubbs, Christopher; Frigola, Joan; Talbot, Sara; Bentouati, Sabrina; Hall, James; Wijnhoven, Paul W. G.; Armenia, Josh; Schimpl, Marianne; Forment, Josep, V; Albertella, Mark R.; O'connor, Mark J.; Illuzzi, Giuditta 分享 收藏
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Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity Smith, James M.; Barlaam, Bernard; Beattie, David; Bradshaw, Lauren; Chan, Ho Man; Chiarparin, Elisabetta; Collingwood, Olga; Cooke, Sophie L.; Cronin, Anna; Cumming, Iain; Dean, Emma; Debreczeni, Judit E.; del Barco Barrantes, Ivan; Diene, Coura; Gianni, Davide; Guerot, Carine; Guo, Xiaoxiao; Guven, Sinem; Hayhow, Thomas G.; Hong, Ted; Kemmitt, Paul D.; Lamont, Gillian M.; Lamont, Scott; Lynch, James T.; McWilliams, Lisa; Moore, Shaun; Raubo, Piotr; Robb, Graeme R.; Robinson, James; Scott, James S.; Srinivasan, Bharath; Steward, Oliver; Stubbs, Christopher J.; Syson, Karl; Tan, Lixiang; Turner, Oliver; Underwood, Elizabeth; Urosevic, Jelena; Vazquez-Chantada, Mercedes; Whittaker, Amy L.; Wilson, David M.; Winter-Holt, Jon J. 分享 收藏
Fragment-Based Discovery of Novel MUS81 Inhibitors 基于片段的新型MUS81抑制剂的发现 Collie, Gavin W.; Borjesson, Ulf; Chen, Yunhua; Dong, Zhiqiang; Di Fruscia, Paolo; Gohlke, Andrea; Hoyle, Anna; Hunt, Thomas A.; Jesani, Mehul H.; Luo, Haiou; Luptak, Jakub; Milbradt, Alexander G.; Narasimhan, Priyanka; Packer, Martin; Patel, Saleha; Qiao, Jingchuan; Storer, R. Ian; Stubbs, Christopher J.; Tart, Jonathan; Truman, Caroline; Wang, Anderson T.; Wheeler, Matthew G.; Winter-Holt, Jon 分享 收藏
Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen Lucas, Simon C. C.; Blackwell, J. Henry; Borjesson, Ulf; Hargreaves, David; Milbradt, Alexander G.; Ahmed, Samiyah; Bostock, Mark J.; Guerot, Carine; Gohlke, Andrea; Kinzel, Olaf; Lamb, Michelle L.; Selmi, Nidhal; Stubbs, Christopher J.; Su, Nancy; Su, Qibin; Luo, Haiou; Xiong, Ting; Zuo, Xiaoqian; Bazzaz, Sana; Bienstock, Corey; Centrella, Paolo A.; Denton, Kyle E.; Gikunju, Diana; Guie, Marie-Aude; Guilinger, John P.; Hupp, Christopher; Keefe, Anthony D.; Satoh, Takashi; Zhang, Ying; Rivers, Emma L. 分享 收藏
High throughput application of the NanoBiT Biochemical Assay for the discovery of selective p110a isoform binders that block its interaction with KRAS Ismail, Mohamed (Soly) Soliman; Downward, Julian; Tart, Jonathan; Davies, Gareth; Monteverde, Tiziana; Hancock, David; Adhikari, Santosh; Stubbs, Christopher; Blackett, Carolyn; Holdgate, Geoff; Kettle, Jason 分享 收藏
Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor Michaelides, Iacovos N.; Collie, Gavin W.; Borjesson, Ulf; Vasalou, Christina; Alkhatib, Omar; Barlind, Louise; Cheung, Tony; Dale, Ian L.; Embrey, Kevin J.; Hennessy, Edward J.; Khurana, Puneet; Koh, Cheryl M.; Lamb, Michelle L.; Liu, Jianming; Moss, Thomas A.; O'Neill, Daniel J.; Phillips, Christopher; Shaw, Joseph; Snijder, Arjan; Storer, R. Ian; Stubbs, Christopher J.; Han, Fujin; Li, Chengzhi; Qiao, Jingchuan; Sun, Dong-Qing; Wang, Jingwen; Wang, Peng; Yang, Wenzhen 分享 收藏
High throughput application of the NanoBiT Biochemical Assay for the discovery of selective p110α isoform binders that block its interaction with KRAS Ismail, Mohamed (Soly) Soliman; Tart, Jonathan; Davies, Gareth; Sproat, Graham; Monterverde, Tiziana; Hancock, David; Adhikari, Santosh; Stubbs, Christopher; Blackett, Carolyn; Holdgate, Geoff; Kettle, Jason; Downward, Julian 分享 收藏
Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function Coleman, Oliver D.; Macdonald, Jessica; Thomson, Ben; Ward, Jennifer A.; Stubbs, Christopher J.; McAllister, Tom E.; Clark, Shane; Amin, Siddique; Cao, Yimang; Abboud, Martine I.; Zhang, Yijia; Sanganee, Hitesh; Huber, Kilian V. M.; Claridge, Tim D. W.; Kawamura, Akane 分享 收藏
Combining structural and coevolution information to unveil allosteric sites La Sala, Giuseppina; Pfleger, Christopher; Kack, Helena; Wissler, Lisa; Nevin, Philip; Bohm, Kerstin; Janet, Jon Paul; Schimpl, Marianne; Stubbs, Christopher J.; De Vivo, Marco; Tyrchan, Christian; Hogner, Anders; Gohlke, Holger; Frolov, Andrey I. 分享 收藏
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Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins Malvezzi, Francesca; Stubbs, Christopher J.; Jowitt, Thomas A.; Dale, Ian L.; Guo, Xieyang; DeGnore, Jon P.; Degliesposti, Gianluca; Skehel, J. Mark; Bannister, Andrew J.; McAlister, Mark S. 分享 收藏
Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model De Fusco, Claudia; Schimpl, Marianne; Borjesson, Ulf; Cheung, Tony; Collie, Iain; Evans, Laura; Narasimhan, Priyanka; Stubbs, Christopher; Vazquez-Chantada, Mercedes; Wagner, David J.; Grondine, Michael; Sanders, Matthew G.; Tentarelli, Sharon; Underwood, Elizabeth; Argyrou, Argyrides; Smith, James M.; Lynch, James T.; Chiarparin, Elisabetta; Robb, Graeme; Bagal, Sharan K.; Scott, James S. 分享 收藏
Structural Basis for Targeting the Folded P-Loop Conformation of c-MET Collie, Gavin W.; Michaelides, Iacovos N.; Embrey, Kevin; Stubbs, Christopher J.; Borjesson, Ulf; Dale, Ian L.; Snijder, Arjan; Barlind, Louise; Song, Kun; Khurana, Puneet; Phillips, Christopher; Storer, R. Ian 分享 收藏
Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies (vol 33, pg 518, 2019) Lawson, Nicola L.; Dix, Carly I.; Scorer, Paul W.; Stubbs, Christopher J.; Wong, Edmond; Hutchinson, Liam; McCall, Eileen J.; Schimpl, Marianne; DeVries, Emma; Walker, Jill; Williams, Gareth H.; Hunt, James; Barker, Craig 分享 收藏
Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies Lawson, Nicola L.; Dix, Carly I.; Scorer, Paul W.; Stubbs, Christopher J.; Wong, Edmond; Hutchinson, Liam; McCall, Eileen J.; Schimpl, Marianne; DeVries, Emma; Walker, Jill; Williams, Gareth H.; Hunt, James; Barker, Craig 分享 收藏
Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes 不同病理中的结构见解和激活突变定义了磷脂酶C γ 酶的失调机制 Liu, Yang; Bunney, Tom D.; Khosa, Sakshi; Mace, Kevin; Beckenbauer, Katharina; Askwith, Trevor; Maslen, Sarah; Stubbs, Christopher; de Oliveira, Taiana M.; Sader, Kasim; Skehel, Mark; Gavin, Anne-Claude; Phillips, Christopher; Katan, Matilda 分享 收藏
Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors Collie, Gavin W.; Koh, Cheryl M.; O'Neill, Daniel J.; Stubbs, Christopher J.; Khurana, Puneet; Eddershaw, Alice; Snijder, Arjan; Mauritzson, Fredrik; Barlind, Louise; Dale, Ian L.; Shaw, Joseph; Phillips, Christopher; Hennessy, Edward J.; Cheung, Tony; Narvaez, Ana J. 分享 收藏
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