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S

Sébastien G. Gouin

Nantes Universite
H指数:35
被引数:4,432

个人简介

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工作经历

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荣誉奖项

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Targeting sialic acid catabolism with polyvalent sialidase inhibitors to mitigate bacterial inflammation in the gut

利用多价神经氨酸酶抑制剂靶向唾液酸分解代谢，以减轻肠道细菌性炎症

Bioorganic Chemistry
IF4.7
2025-11-210
PRE
Mélyne Baudin Marie; Zoé Oblette; Mathieu Scalabrini; Denis Loquet; Devon W. Kavanaugh; David Deniaud; Thomas Bessonnet; Nizar Amzil; Aziz Elgarrab; Cyrille Grandjean; Clément Gonnot; Fabien Boeda; Laurent Fontaine; Véronique Montembault; Franck Daligault; Nicolas Barnich; Adeline Sivignon; Sébastien G. Gouin
Advancing liver gene therapy: Enhanced transduction with GalNAc-bioconjugated rAAV capsids

推进肝脏基因治疗：利用GalNAc生物缀合的rAAV衣壳增强转导

Biomedicine & Pharmacotherapy
IF7.5
2025-06-270
OA
Pierre-Alban Lalys; Audrey Bourdon; Mohammed Bouzelha; Dimitri Alvarez-Dorta; Karine Pavageau; Tiphaine Girard; Roxane Peumery; Zakaria Bouchouireb; Maia Marchand; Anthony Mellet; Nicolas Jaulin; Mireille Ledevin; Olivia Terceve; Sébastien Depienne; Mickaël Guilbaud; Mikaël Croyal; Sébastien G. Gouin; Benoit Roubinet; Ludovic Landemarre; Oumeya Adjali; David Deniaud
Ligand-modified rAAV6 vectors with nanoblades allow high-level gene knockin in HSPCs without compromising cell survival

纳米刃修饰的rAAV6载体能够实现造血干细胞和祖细胞(HSPCs)的高效基因敲入，且不影响细胞存活。

MOLECULAR THERAPY NUCLEIC ACIDS
IF6.1
2025-02-010
OAAI
Gutierrez-Guerrero, Alejandra; Perian, Severine; Leray, Aurelien; Martinello, Chiara; Recalde, Maria Jimena Abrey; Costa, Caroline; Herrero, Cecilia Iglesias; Bouzelha, Mohammed; Alvarez-Dorta, Dimitri; Gouin, Sebastien G.; Ayuso, Eduard; Adjali, Oumeya; Buning, Hildegard; Deniaud, David; Mevel, Mathieu
Novel chemical tyrosine functionalization of adeno-associated virus improves gene transfer efficiency in liver and retina

腺相关病毒的新型化学酪氨酸功能化可提高肝脏和视网膜的基因转移效率

BIOMEDICINE & PHARMACOTHERAPY
IF7.5
2024-02-014
OAAI
Leray, Aurelien; Lalys, Pierre-Alban; Varin, Juliette; Bouzelha, Mohammed; Bourdon, Audrey; Alvarez-Dorta, Dimitri; Pavageau, Karine; Depienne, Sebastien; Marchand, Maia; Mellet, Anthony; Demilly, Joanna; Ducloyer, Jean -Baptiste; Girard, Tiphaine; Fraysse, Bodvael; Ledevin, Mireille; Guilbaud, Mickael; Gouin, Sebastien G.; Ayuso, Eduard; Adjali, Oumeya; Larcher, Thibaut; Cronin, Therese; Le Guiner, Caroline; Deniaud, David; Mevel, Mathieu
Polyvalent Transition-State Analogues of Sialyl Substrates Strongly Inhibit Bacterial Sialidases
CHEMISTRY-A EUROPEAN JOURNAL
IF3.7
2021-01-1510
OAAI
Assailly, Coralie; Bridot, Clarisse; Saumonneau, Amelie; Lottin, Paul; Roubinet, Benoit; Krammer, Eva-Maria; Francois, Francesca; Vena, Federica; Landemarre, Ludovic; Alvarez Dorta, Dimitri; Deniaud, David; Grandjean, Cyrille; Tellier, Charles; Pascual, Sagrario; Montembault, Veronique; Fontaine, Laurent; Daligault, Franck; Bouckaert, Julie; Gouin, Sebastien G.
Multivalent Thiosialosides and Their Synergistic Interaction with Pathogenic Sialidases

多价硫代糖苷及其与致病性唾液酸酶的协同相互作用

CHEMISTRY-A EUROPEAN JOURNAL
IF3.7
2019-01-1118
PREAI
Brissonnet, Yoan; Assailly, Coralie; Saumonneau, Amelie; Bouckaert, Julie; Maillasson, Mike; Petitot, Clemence; Roubinet, Benoit; Didak, Blanka; Landemarre, Ludovic; Bridot, Clarisse; Blossey, Ralf; Deniaud, David; Yan, Xibo; Bernard, Julien; Tellier, Charles; Grandjean, Cyrille; Daligault, Franck; Gouin, Sebastien G.

研究方向

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D
David Deniaud
H 指数:27论文数:163被引数:2,249
D
Dimitri Álvarez‐Dorta
H 指数:16论文数:58被引数:936
J
Julie Bouckaert
H 指数:43论文数:224被引数:5,836
A
Adeline Sivignon
H 指数:19论文数:69被引数:1,631
N
Nicolas Barnich
H 指数:58论文数:350被引数:1.5万
B
Benoît Roubinet
H 指数:14论文数:44被引数:775
J
José Kovensky
H 指数:29论文数:130被引数:2,714
L
Ludovic Landemarre
H 指数:14论文数:51被引数:486
M
Mathieu Mével
H 指数:20论文数:54被引数:1,188
M
Mohammed Bouzelha
H 指数:10论文数:38被引数:519