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Generation of Bioactivity-Tailored FK506/FK520 Analogs by CRISPR Editing in Streptomyces tsukubaensis Buntin, Kathrin; Mrak, Peter; Lukancic, Petra Pivk; Wollbrett, Severine; Drcar, Tjasa; Krastel, Philipp; Thibaut, Christian; Salcius, Michael; Gao, Xiaolin; Wang, Shaowen; Weber, Eric; Koplan, Eva; Regenass, Hugo 分享 收藏
CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism Cho, Hyelim; Shen, Qiong; Zhang, Lydia H.; Okumura, Mikiko; Kawakami, Akinori; Ambrose, Jessi; Sigoillot, Frederic; Miller, Howard R.; Gleim, Scott; Cobos-Correa, Amanda; Wang, Ying; Piechon, Philippe; Roma, Guglielmo; Eggimann, Fabian; Moore, Charles; Aspesi, Peter, Jr.; Mapa, Felipa A.; Burks, Heather; Ross, Nathan T.; Krastel, Philipp; Hild, Marc; Maimone, Thomas J.; Fisher, David E.; Nomura, Daniel K.; Tallarico, John A.; Canham, Stephen M.; Jenkins, Jeremy L.; Forrester, William C. 分享 收藏
Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury Larraufie, Marie-Helene; Gao, Xiaolin; Xia, Xiaobo; Devine, Patrick J.; Kallen, Joerg; Liu, Dong; Michaud, Gregory; Harsch, Andreas; Savage, Nik; Ding, Jian; Tan, Kian; Mihalic, Manuel; Roggo, Silvio; Canham, Stephen M.; Bushell, Simon M.; Krastel, Philipp; Gao, Jinhai; Izaac, Aude; Altinoglu, Erhan; Lustenberger, Philipp; Salcius, Michael; Harbinski, Fred; Williams, Eric T.; Zeng, Liling; Loureiro, Joseph; Cong, Feng; Fryer, Christy J.; Klickstein, Lloyd; Tallarico, John A.; Jain, Rishi K.; Rothman, Deborah M.; Wang, Shaowen 分享 收藏
Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus Ganapathy, Uday S.; Lan, Tian; Krastel, Philipp; Lindman, Marissa; Zimmerman, Matthew D.; Ho, HsinPin; Sarathy, Jansy P.; Evans, Joanna C.; Dartois, Veronique; Aldrich, Courtney C.; Dick, Thomas 分享 收藏
Evolution of Novartis' Small Molecule Screening Deck Design 诺华小分子筛板设计的演变 Schuffenhauer, Ansgar; Schneider, Nadine; Hintermann, Samuel; Auld, Douglas; Blank, Jutta; Cotesta, Simona; Engeloch, Caroline; Fechner, Nikolas; Gaul, Christoph; Giovannoni, Jerome; Jansen, Johanna; Joslin, John; Krastel, Philipp; Lounkine, Eugen; Manchester, John; Monovich, Lauren G.; Pelliccioli, Anna Paola; Schwarze, Manuel; Shultz, Michael D.; Stiefl, Nikolaus; Baeschlin, Daniel K. 分享 收藏
HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis HuR/ELAVL1驱动恶性外周神经鞘瘤生长和转移 Palomo-Irigoyen, Marta; Perez-Andres, Encarni; Iruarrizaga-Lejarreta, Marta; Barreira-Manrique, Adrian; Tamayo-Caro, Miguel; Vila-Vecilla, Laura; Moreno-Cugnon, Leire; Beitia, Nagore; Medrano, Daniela; Fernandez-Ramos, David; Lozano, Juan Jose; Okawa, Satoshi; Lavin, Jose L.; Martin-Martin, Natalia; Sutherland, James D.; de Juan, Virginia Guitierez; Gonzalez-Lopez, Monika; Macias-Camara, Nuria; Mosen-Ansorena, David; Laraba, Liyam; Hanemann, C. Oliver; Ercolano, Emanuela; Parkinson, David B.; Schultz, Christopher W.; Arauzo-Bravo, Marcos J.; Ascension, Alex M.; Gerovska, Daniela; Iribar, Haizea; Izeta, Ander; Pytel, Peter; Krastel, Philipp; Provenzani, Alessandro; Seneci, Pierfausto; Carrasco, Ruben D.; Del Sol, Antonio; Martinez-Chantar, Maria Luz; Barrio, Rosa; Serra, Eduard; Lazaro, Conxi; Flanagan, Adrienne M.; Gorospe, Myriam; Ratner, Nancy; Aransay, Ana M.; Carracedo, Arkaitz; Varela-Rey, Marta; Woodhoo, Ashwin 分享 收藏
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Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import Filipuzzi, Ireos; Steffen, Janos; Germain, Mitchel; Goepfert, Laetitia; Conti, Michael A.; Potting, Christoph; Cerino, Raffaele; Pfeifer, Martin; Krastel, Philipp; Hoepfner, Dominic; Bastien, Julie; Koehler, Carla M.; Helliwell, Stephen B. 分享 收藏
Antibacterial and Solubility Optimization of Thiomuracin A LaMarche, Matthew J.; Leeds, Jennifer A.; Brewer, Jason; Dean, Karl; Ding, Jian; Dzink-Fox, Joanne; Gamber, Gabe; Jain, Akash; Kerrigan, Ryan; Krastel, Philipp; Lee, Kwangho; Lombardo, Franco; McKenney, David; Neckermann, Georg; Osborne, Colin; Palestrant, Deborah; Patane, Michael A.; Rann, Elin M.; Robinson, Zachary; Schmitt, Esther; Stams, Travis; Tiamfook, Stacey; Yu, Donghui; Whitehead, Lewis 分享 收藏
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Dark chemical matter as a promising starting point for drug lead discovery Wassermann, Anne Mai; Lounkine, Eugen; Hoepfner, Dominic; Le Goff, Gaelle; King, Frederick J.; Studer, Christian; Peltier, John M.; Grippo, Melissa L.; Prindle, Vivian; Tao, Jianshi; Schuffenhauer, Ansgar; Wallace, Iain M.; Chen, Shanni; Krastel, Philipp; Cobos-Correa, Amanda; Parker, Christian N.; Davies, John W.; Glick, Meir 分享 收藏
FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p Helliwell, Stephen B.; Karkare, Shantanu; Bergdoll, Marc; Rahier, Alain; Leighton-Davis, Juliet R.; Fioretto, Celine; Aust, Thomas; Filipuzzi, Ireos; Frederiksen, Mathias; Gounarides, John; Hoepfner, Dominic; Hofmann, Andreas; Imbert, Pierre-Eloi; Jeker, Rolf; Knochenmuss, Richard; Krastel, Philipp; Margerit, Anais; Memmert, Klaus; Miault, Charlotte V.; Movva, N. Rao; Muller, Alban; Naegeli, Hans-Ulrich; Oberer, Lukas; Prindle, Vivian; Riedl, Ralph; Schuierer, Sven; Sexton, Jessica A.; Tao, Jianshi; Wagner, Trixie; Yin, Hong; Zhang, Juan; Roggo, Silvio; Reinker, Stefan; Parker, Christian N. 分享 收藏
Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon Decatransin，一种新的天然产物，可抑制Sec61/SecYEG易位的蛋白质易位 Junne, Tina; Wong, Joanne; Studer, Christian; Aust, Thomas; Bauer, Benedikt W.; Beibel, Martin; Bhullar, Bhupinder; Bruccoleri, Robert; Eichenberger, Juerg; Estoppey, David; Hartmann, Nicole; Knapp, Britta; Krastel, Philipp; Melin, Nicolas; Oakeley, Edward J.; Oberer, Lukas; Riedl, Ralph; Roma, Guglielmo; Schuierer, Sven; Petersen, Frank; Tallarico, John A.; Rapoport, Tom A.; Spiess, Martin; Hoepfner, Dominic 分享 收藏
High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions Hoepfner, Dominic; Helliwell, Stephen B.; Sadlish, Heather; Schuierer, Sven; Filipuzzi, Ireos; Brachat, Sophie; Bhullar, Bhupinder; Plikat, Uwe; Abraham, Yann; Altorfer, Marc; Aust, Thomas; Baeriswyl, Lukas; Cerino, Raffaele; Chang, Lena; Estoppey, David; Eichenberger, Juerg; Frederiksen, Mathias; Hartmann, Nicole; Hohendahl, Annika; Knapp, Britta; Krastel, Philipp; Melin, Nicolas; Nigsch, Florian; Oakeley, Edward J.; Petitjean, Virginie; Petersen, Frank; Riedl, Ralph; Schmitt, Esther K.; Staedtler, Frank; Studer, Christian; Tallarico, John A.; Wetzel, Stefan; Fishman, Mark C.; Porter, Jeffrey A.; Movva, N. Rao 分享 收藏
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Antibiotic Optimization and Chemical Structure Stabilization of Thiomuracin A (vol 55, pg 6934, 2012) LaMarche, Matthew J.; Leeds, Jennifer A.; Dzink-Fox, Joanne; Gangl, Eric; Krastel, Philipp; Neckermann, Georg; Palestrant, Deborah; Patane, Michael A.; Rann, Elin M.; Tiamfook, Stacey; Yu, Donghui 分享 收藏
Antibiotic Optimization and Chemical Structure Stabilization of Thiomuracin A LaMarche, Matthew J.; Leeds, Jennifer A.; Dzink-Fox, Joanne; Gangl, Eric; Krastel, Philipp; Neckermann, Georg; Paestrant, Deborah; Patane, Michael A.; Rann, Elm N. M.; Tiarnfook, Stacey; Yu, Donghui 分享 收藏
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The Natural Product Cyclomarin Kills Mycobacterium Tuberculosis by Targeting the ClpC1 Subunit of the Caseinolytic Protease Schmitt, Esther K.; Riwanto, Meliana; Sambandamurthy, Vasan; Roggo, Silvio; Miault, Charlotte; Zwingelstein, Christian; Krastel, Philipp; Noble, Christian; Beer, David; Rao, Srinivasa P. S.; Au, Melvin; Niyomrattanakit, Pornwaratt; Lim, Viviam; Zheng, Jun; Jeffery, Douglas; Pethe, Kevin; Camacho, Luis R. 分享 收藏
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