Subhash C. Sinha - Publications, H-index & Citations

Subhash C. Sinha

weill cornell medicine

39H指数

216论文数

4.0K被引数

收录论文 66

发表时间

cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsy cGAS介导的I型IFN信号通路促进耐药性癫痫疾病进展

Nature Neuroscience

IF20

2026-07-29

OAAI

Yige Huang; Li Fan; Man Ying Wong; Zhuofan Lei; Balaji Krishnamachary; Daphne Zhu; Mika P. Cadiz; Ravi Kumar Nagiri; Pearly Ye; Kendra Norman; Maitreyee Bhagwat; Young Jae Lee; Hui Li; Jingjie Zhu; Sadaf Amin; Kelli Lauderdale; Hao Chen; Wenjie Luo; Shiaoching Gong; Benjamin L. Liechty; Jorge J. Palop; Subhash C. Sinha; Junfang Wu; Mingrui Zhao; Li Gan

AI guided discovery of a murine model of asymptomatic Alzheimer’s disease AI指导下无症状阿尔茨海默病小鼠模型的发现

Acta Neuropathologica Communications

IF5.7

2026-04-04

OAAI

Suborno Jati; Sahar Taheri; Satadeepa Kal; Subhash C. Sinha; Brian P. Head; Sushil K. Mahata; Debashis Sahoo

High-Throughput Screening and Initial SAR Studies Identify a Novel Submicromolar Potent Human cGAS Inhibitor

ACS CHEMICAL BIOLOGY

IF3.8

2025-11-01

PREAI

Alarcon-Esposito, Jazmin; Nagiri, Ravi Kumar; Wang, Siyu; Larson, Chloe; Carvallo-Torres, Loreto; Singh, Vipin Kumar; Glickman, J. Fraser; Gan, Li; Sinha, Subhash C.

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway APOE3基因中的R136S突变通过抑制cGAS-STING-IFN通路赋予对tau病理的抵抗力。

Immunity

IF26.3

2025-06-23

PREAI

Sarah Naguib; Chloe Lopez-Lee; Eileen Ruth Torres; Se-In Lee; Jingjie Zhu; Daphne Zhu; Pearly Ye; Kendra Norman; Mingrui Zhao; Man Ying Wong; Yohannes A. Ambaw; Rodrigo Muñoz-Castañeda; Wei Wang; Tark Patel; Maitreyee Bhagwat; Rada Norinsky; Sue-Ann Mok; Tobias C. Walther; Robert V. Farese; Wenjie Luo; Subhash C. Sinha; Zhuhao Wu; Li Fan; Shiaoching Gong; Li Gan

Emerging approaches to bridging discovery science with clinical care in Alzheimer's disease 将阿尔茨海默病中的发现科学与临床护理相结合的 emerging approaches

NEUROTHERAPEUTICS

IF6.9

2025-04-01

OAAI

Sinha, Subhash; Gan, Li; Pieper, Andrew A.

Identification and development of cGAS inhibitors and their uses to treat Alzheimer's disease cGAS抑制剂的鉴定与开发及其在治疗阿尔茨海默病中的应用

NEUROTHERAPEUTICS

IF6.9

2025-01-01

OAAI

Alarcon-Esposito, Jazmin; Nagiri, Ravi Kumar; Gan, Li; Sinha, Subhash C.

Editorial: Spotlight on North America - chemical sciences

FRONTIERS IN CHEMISTRY

IF4.2

2024-12-03

OAAI

Sinha, Subhash C.; Ummadisetti, Chinna Rajesh; Laali, Kenneth K.; Bao, Kai; Bhupathiraju, Naga V. S. D. K.; Ojima, Iwao

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

NEURON

IF15

2024-12-01

OAAI

Carling, Gillian K.; Fan, Li; Foxe, Nessa R.; Norman, Kendra; Wong, Man Ying; Zhu, Daphne; Corona, Carlo; Razzoli, Agnese; Yu, Fangmin; Yarahmady, Allan; Ye, Pearly; Chen, Hao; Huang, Yige; Amin, Sadaf; Sereda, Rebecca; Lopez-Lee, Chloe; Zacharioudakis, Emmanouil; Chen, Xiaoying; Xu, Jielin; Cheng, Feixiong; Gavathiotis, Evripidis; Cuervo, Ana Maria; Holtzman, David M.; Mok, Sue-Ann; Sinha, Subhash C.; Sidoli, Simone; Ratan, Rajiv R.; Luo, Wenjie; Gong, Shiaoching; Gan, Li

Stretching the structural envelope of imatinib to reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP

FRONTIERS IN CHEMISTRY

IF4.2

2024-10-08

OAAI

Netzer, William J.; Sinha, Anjana; Ghias, Mondana; Chang, Emily; Gindinova, Katherina; Mui, Emily; Seo, Ji-Seon; Sinha, Subhash C.

Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury

MOLECULAR NEURODEGENERATION

IF17.5

2024-06-24

OAAI

Bravo, Celeste Parra; Krukowski, Karen; Barker, Sarah; Wang, Chao; Li, Yaqiao; Fan, Li; Vazquez-Rosa, Edwin; Shin, Min-Kyoo; Wong, Man Ying; McCullough, Louise D.; Kitagawa, Ryan S.; Choi, H. Alex; Cacace, Angela; Sinha, Subhash C.; Pieper, Andrew A.; Rosi, Susanna; Chen, Xu; Gan, Li

Ahnak in the prefrontal cortex mediates behavioral correlates of stress resilience and rapid antidepressant action in mice

FRONTIERS IN MOLECULAR NEUROSCIENCE

IF3.8

2024-05-17

OAAI

Bhatti, Dionnet L.; Jin, Junghee; Cheng, Jia; McCabe, Kathryn; Lee, Ko-Woon; Berdasco, Clara; Jeong, Yu Young; Sinha, Subhash C.; Kim, Yong

A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons

BRAIN

IF11.7

2024-03-11

OAAI

Rodriguez-Rodriguez, Patricia; Arroyo-Garcia, Luis Enrique; Tsagkogianni, Christina; Li, Lechuan; Wang, Wei; Vegvari, Akos; Salas-Allende, Isabella; Plautz, Zakary; Cedazo-Minguez, Angel; Sinha, Subhash C.; Troyanskaya, Olga; Flajolet, Marc; Yao, Vicky; Roussarie, Jean-Pierre

Rational Development of a Small-Molecule Activator of CK1γ2 That Decreases C99 and Beta-Amyloid Levels

ACS CHEMICAL BIOLOGY

IF3.8

2023-12-11

OAAI

Bustos, Victor Hugo; Sunkari, Yashoda Krishna; Sinha, Anjana; Pulina, Maria; Bispo, Ashley; Hopkins, Maya; Lam, Alison; Kriegsman, Sydney F.; Mui, Emily; Chang, Emily; Jedlicki, Ana; Rosenthal, Hannah; Flajolet, Marc; Sinha, Subhash C.

Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders

MOLECULAR NEURODEGENERATION

IF17.5

2023-11-08

OAAI

Huang, Yige; Liu, Bangyan; Sinha, Subhash C.; Amin, Sadaf; Gan, Li

TrkA expression directs the anti-neoplastic activity of MLK3 inhibitors in triple-negative breast cancer

ONCOGENE

IF7.3

2023-02-22

PREAI

Nair, Rakesh Sathish; Kumar, Sandeep; Das, Subhasis; Singh, Sunil Kumar; Srivastava, Piush; Sondarva, Gautam; Rao, Arundhati; Sinha, Subhash C. C.; Xiong, Rui; Bloem, Laura; Hoskins, Kent; Thatcher, Gregory R. J.; Rana, Basabi; Rana, Ajay

AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2021-12-01

OAAI

Sayed, Faten A.; Kodama, Lay; Fan, Li; Carling, Gillian K.; Udeochu, Joe C.; Le, David; Li, Qingyun; Zhou, Lu; Wong, Man Ying; Horowitz, Rose; Ye, Pearly; Mathys, Hansruedi; Wang, Minghui; Niu, Xiang; Mazutis, Linas; Jiang, Xueqiao; Wang, Xueting; Gao, Fuying; Brendel, Matthew; Telpoukhovskaia, Maria; Tracy, Tara E.; Frost, Georgia; Zhou, Yungui; Li, Yaqiao; Qiu, Yue; Cheng, Zuolin; Yu, Guoqiang; Hardy, John; Coppola, Giovanni; Wang, Fei; DeTure, Michael A.; Zhang, Bin; Xie, Lei; Trajnowski, John Q.; Lee, Virginia M. Y.; Gong, Shiaoching; Sinha, Subhash C.; Dickson, Dennis W.; Luo, Wenjie; Gan, Li

MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3

ONCOGENE

IF7.3

2021-09-13

OAAI

Singh, Sunil Kumar; Kumar, Sandeep; Viswakarma, Navin; Principe, Daniel R.; Das, Subhasis; Sondarva, Gautam; Nair, Rakesh Sathish; Srivastava, Piush; Sinha, Subhash C.; Grippo, Paul J.; Thatcher, Gregory R. J.; Rana, Basabi; Rana, Ajay

Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development

CANCER LETTERS

IF10.1

2021-09-01

OAAI

Viswakarma, Navin; Sondarva, Gautam; Principe, Daniel R.; Nair, Rakesh Sathish; Kumar, Sandeep; Singh, Sunil Kumar; Das, Subhasis; Sinha, Subhash C.; Grippo, Paul J.; Grimaldo, Sam; Giulianotti, Pier Cristoforo; Rana, Basabi; Rana, Ajay

Reduced Kv3.1 Activity in Dentate Gyrus Parvalbumin Cells Induces Vulnerability to Depression

BIOLOGICAL PSYCHIATRY

IF9

2020-09-01

OAAI

Medrihan, Lucian; Umschweif, Gali; Sinha, Anjana; Reed, Shayna; Lee, Jinah; Gindinova, Katherina; Sinha, Subhash C.; Greengard, Paul; Sagi, Yotam

A Pentacyclic Triterpene from Ligustrum lucidum Targets γ-Secretase

ACS CHEMICAL NEUROSCIENCE

IF3.9

2020-08-10

OAAI

Luo, Wenjie; Ip, Fanny C. F.; Fu, Guangmiao; Cheung, Kit; Tian, Yuan; Hu, Yueqing; Sinha, Anjana; Cheng, Elaine Y. L.; Wu, Xianzhong; Bustos, Victor; Greengard, Paul; Li, Yue-Ming; Sinha, Subhash C.; Ip, Nancy Y.

研究方向