未登录An engineered cereblon optimized for high-throughput screening and molecular glue discovery
Bailey, Henry J.; Eisert, Jonathan; Kazi, Rubina; Gerhartz, Jan; Pienkowska, Dominika Ewa; Dressel, Ina; Vollrath, Joshua; Kondratov, Ivan; Matviyuk, Tetiana; Tolmachova, Nataliya; Shah, Varun Jayeshkumar; Giuliani, Giulio; Mosler, Thorsten; Geiger, Thomas M.; Esteves, Ana M.; Santos, Sandra P.; Sousa, Raquel L.; Bandeiras, Tiago M.; Leibrock, Eva-Maria; Bauer, Ulrike; Leuthner, Birgitta; Langer, Julian D.; Wegener, Ansgar A.; Nowak, Radosla P.; Sorrel, Fiona J.; Dikic, Ivan .png)
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收藏Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib bindingGraedler, Ulrich; Schwarz, Daniel; Wegener, Ansgar; Eichhorn, Thomas; Bandeiras, Tiago M.; Freitas, Micael C.; Lammens, Alfred; Ganichkin, Oleg; Augustin, Martin; Minguzzi, Stefano; Becker, Frank; Bomke, Jorg 分享 收藏 Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α InhibitorsBuchstaller, Hans-Peter; Sala-Hojman, Ada; Leiendecker, Matthias; Albers, Joachim; Anlauf, Uwe; Berges, Nina; Dong, Liming; Fuchss, Thomas; Germann, Martina; Knehans, Tim; Krier, Mireille; Lecomte, Marc; Mueller, Daniel; Mueller, Sandra R. R.; Leuthner, Birgitta; Lindemann, Ralph; Musil, Djordje; Nowak, Mateusz; Reither, Vivian; Rettig, Corinna; Schindler, Christina E. M.; Pakulska, Urszula; Spuck, Dieter; Wegener, Ansgar; Zarebski, Adrian 分享 收藏 Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC DesignKrieger, Johannes; Sorrell, Fiona J.; Wegener, Ansgar A.; Leuthner, Birgitta; Machrouhi-Porcher, Fouzia; Hecht, Martin; Leibrock, Eva M.; Mueller, Juliane E.; Eisert, Jonathan; Hartung, Ingo V.; Schlesiger, Sarah 分享 收藏 Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responsesLan, Yan; Yeung, Tsz-Lun; Huang, Hui; Wegener, Ansgar A.; Saha, Somdutta; Toister-Achituv, Mira; Jenkins, Molly H.; Chiu, Li-Ya; Lazorchak, Adam; Tarcic, Ohad; Wang, Hong; Qi, Jin; Locke, George; Kalimi, Doron; Qin, Guozhong; Marelli, Bo; Yu, Huakui; Gross, Alec W.; Derner, Melissa G.; Soloviev, Maria; Botte, Mathieu; Sircar, Aroop; Ma, Hong; Sood, Vanita D.; Zhang, Dong; Jiang, Feng; Lo, Kin-Ming 分享 收藏 Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 BiologyHeinrich, Timo; Sala-Hojman, Ada; Ferretti, Roberta; Petersson, Carl; Minguzzi, Stefano; Gondela, Andrzej; Ramaswamy, Shivapriya; Bartosik, Anna; Czauderna, Frank; Crowley, Lindsey; Wahra, Pamela; Schilke, Heike; Boepple, Pia; Dudek, Lukasz; Les, Marcin; Niedziejko, Paulina; Olech, Kamila; Pawlik, Henryk; Wloszczak, Lukasz; Zuchowicz, Karol; Suarez Alvarez, Jose Ramon; Martyka, Justyna; Sitek, Ewa; Mikulski, Maciej; Szczesniak, Joanna; Jaeckel, Sven; Krier, Mireille; Krol, Marcin; Wegener, Ansgar; Galezowski, Michal; Nowak, Mateusz; Becker, Frank; Herhaus, Christian 分享 收藏 Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer ModelsBuchstaller, Hans-Peter; Anlauf, Uwe; Dorsch, Dieter; Kogler, Sarah; Kuhn, Daniel; Lehmann, Martin; Leuthner, Birgitta; Lodholz, Sara; Musil, Djordje; Radtki, Daniela; Rettig, Corinna; Ritzert, Claudio; Rohdich, Felix; Schneider, Richard; Wegener, Ansgar; Weigt, Stefan; Wilkinson, Kai; Esdar, Christina 分享 收藏 Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects活性药物发现项目中结合自由能计算的大规模评估Schindler, Christina E. M.; Baumann, Hannah; Blum, Andreas; Boese, Dietrich; Buchstaller, Hans-Peter; Burgdorf, Lars; Cappel, Daniel; Chekler, Eugene; Czodrowski, Paul; Dorsch, Dieter; Eguida, Merveille K., I; Follows, Bruce; Fuchss, Thomas; Graedler, Ulrich; Gunera, Jakub; Johnson, Theresa; Lebrun, Catherine Jorand; Karra, Srinivasa; Klein, Markus; Knehans, Tim; Koetzner, Lisa; Krier, Mireille; Leiendecker, Matthias; Leuthner, Birgitta; Li, Liwei; Mochalkin, Igor; Musil, Djordje; Neagu, Constantin; Rippmann, Friedrich; Schiemann, Kai; Schulz, Robert; Steinbrecher, Thomas; Tanzer, Eva-Maria; Lopez, Andrea Unzue; Follis, Ariele Viacava; Wegener, Ansgar; Kuhn, Daniel 分享 收藏 Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of CancerHeinrich, Timo; Seenisamy, Jeyaprakashnarayanan; Becker, Frank; Blume, Beatrix; Bomke, Joerg; Dietz, Melanie; Eckert, Uwe; Friese-Hamim, Manja; Gunera, Jakub; Hansen, Kerrin; Leuthner, Birgitta; Musil, Djordje; Pfalzgraf, Jens; Rohdich, Felix; Siegl, Christian; Spuck, Dieter; Wegener, Ansgar; Zenker, Frank T. 分享 收藏 Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological DiseasesCaldwell, Richard D.; Qiu, Hui; Askew, Ben C.; Bender, Andrew T.; Brugger, Nadia; Camps, Montserrat; Dhanabal, Mohanraj; Dutt, Vikram; Eichhorn, Thomas; Gardberg, Anna S.; Goutopoulos, Andreas; Grenningloh, Roland; Head, Jared; Healey, Brian; Hodous, Brian L.; Huck, Bayard R.; Johnson, Theresa L.; Jones, Christopher; Jones, Reinaldo C.; Mochalkin, Igor; Morandi, Federica; Ngan Nguyen; Meyring, Michael; Potnick, Justin R.; Santos, Dusica Cvetinovic; Schmidt, Ralf; Sherer, Brian; Shutes, Adam; Urbahns, Klaus; Follis, Ariele Viacava; Wegener, Ansgar A.; Zimmerli, Simone C.; Liu-Bujalski, Lesley 分享 收藏 分享 收藏 Protein conformational flexibility modulates kinetics and thermodynamics of drug bindingAmaral, M.; Kokh, D. B.; Bomke, J.; Wegener, A.; Buchstaller, H. P.; Eggenweiler, H. M.; Matias, P.; Sirrenberg, C.; Wade, R. C.; Frech, M. 分享 收藏 分享 收藏 分享 收藏 
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