未登录From Sample to Mixed Reality: A Translational 3D MALDI Imaging Platform for Advanced 3D Spatial Omics Analysis of 3D Cell Culture Disease Models
Iakab, Stefania Alexandra; Cordes, Jonas; Enzlein, Thomas; Keller, Florian; Kastner, Kevin; Mulholland, Theresa; Frohlich, Bjorn Christian; Gruber, Lars; Cairns, James Lucas; Schmidt, Stefan; Hafner, Mathias; Schneider, Richard; Betge, Johannes; Fischer, Frank; Reichwald, Julian; Rudolf, Rudiger; Hopf, Carsten .png)
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收藏Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors表型筛选识别和优化新型泛TEAD及亚型选择性抑制剂Heinrich, Timo; Gambardella, Alessia; Schwarz, Daniel; Petersson, Carl; Gunera, Jakub; Garg, Sakshi; Schneider, Richard; Keil, Marina; Grimmeisen, Lisa; Unzue Lopez, Andrea; Schilke, Heike; Weitzel, Thomas; Kolb, Christian; Diehl, Patrizia; Doerfel, Benjamin; Anlauf, Uwe; Reither, Vivian; Rettig, Corinna; Opelt, Beate; Delp, Andrea; Wildner, Nicole; Musil, Djordje; Friedrich, Erik; Burgdorf, Lars; Fuchss, Thomas; Albers, Lisa; Sousa, Pedro M. F.; Freire, Filipe; M. Bandeiras, Tiago; Wienke, Dirk 分享 收藏 分享 收藏 MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686Heinrich, Timo; Schwarz, Daniel; Petersson, Carl; Gunera, Jakub; Garg, Sakshi; Schneider, Richard; Keil, Marina; Grimmeisen, Lisa; Unzue Lopez, Andrea; Albers, Lisa; Schlesiger, Sarah; Gambardella, Alessia; Bomke, Joerg; Carswell, Emma; Schilke, Heike; Diehl, Patrizia; Doerfel, Benjamin; Musil, Djordje; Trivier, Elisabeth; Broome, Rebecca; Marshall, Sam; Balsiger, Alexander; Friedrich, Erik; Lemos, Ana R.; Santos, Sandra P.; Sousa, Pedro M. F.; Freire, Filipe; Bandeiras, Tiago M.; Bortoluzzi, Alessio; Wienke, Dirk 分享 收藏 分享 收藏 Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106Heinrich, Timo; Peterson, Carl; Schneider, Richard; Garg, Sakshi; Schwarz, Daniel; Gunera, Jakub; Seshire, Anita; Koetzner, Lisa; Schlesiger, Sarah; Musil, Djordje; Schilke, Heike; Doerfel, Benjamin; Diehl, Patrizia; Boepple, Pia; Lemos, Ana R.; Sousa, Pedro M. F.; Freire, Filipe; Bandeiras, Tiago M.; Carswell, Emma; Pearson, Nicholas; Sirohi, Sameer; Hooker, Mollie; Trivier, Elisabeth; Broome, Rebecca; Balsiger, Alexander; Crowden, Abigail; Dillon, Christian; Wienke, Dirk 分享 收藏 Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer ModelsBuchstaller, Hans-Peter; Anlauf, Uwe; Dorsch, Dieter; Kogler, Sarah; Kuhn, Daniel; Lehmann, Martin; Leuthner, Birgitta; Lodholz, Sara; Musil, Djordje; Radtki, Daniela; Rettig, Corinna; Ritzert, Claudio; Rohdich, Felix; Schneider, Richard; Wegener, Ansgar; Weigt, Stefan; Wilkinson, Kai; Esdar, Christina 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Routine Optical Clearing of 3D-Cell Cultures: Simplicity ForwardNuernberg, Elina; Vitacolonna, Mario; Klicks, Julia; von Molitor, Elena; Cesetti, Tiziana; Keller, Florian; Bruch, Roman; Ertongur-Fauth, Torsten; Riedel, Katja; Scholz, Paul; Lau, Thorsten; Schneider, Richard; Meier, Julia; Hafner, Mathias; Rudolf, Ruediger 分享 收藏 Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway ActivityBuchstaller, Hans-Peter; Anlauf, Uwe; Dorsch, Dieter; Kuhn, Daniel; Lehmann, Martin; Leuthner, Birgitta; Musil, Djordje; Radtki, Daniela; Ritzert, Claudio; Rohdich, Felix; Schneider, Richard; Esdar, Christina 分享 收藏 A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitorsMenon, Malini; Elliott, Richard; Bowers, Leandra; Balan, Nicolae; Rafiq, Rumana; Costa-Cabral, Sara; Munkonge, Felix; Trinidade, Ines; Porter, Roderick; Campbell, Andrew D.; Johnson, Emma R.; Esdar, Christina; Buchstaller, Hans-Peter; Leuthner, Birgitta; Rohdich, Felix; Schneider, Richard; Sansom, Owen; Wienke, Dirk; Ashworth, Alan; Lord, Christopher J. 分享 收藏 Thymidine Metabolism as a Confounding Factor for 3'-Deoxy-3'-18F-Fluorothymidine Uptake After Therapy in a Colorectal Cancer ModelSchelhaas, Sonja; Wachsmuth, Lydia; Hermann, Sven; Rieder, Natascha; Heller, Astrid; Heinzmann, Kathrin; Honess, Davina J.; Smith, Donna-Michelle; Fricke, Inga B.; Just, Nathalie; Doblas, Sabrina; Sinkus, Ralph; Doering, Christian; Schaefers, Klaus P.; Griffiths, John R.; Faber, Cornelius; Schneider, Richard; Aboagye, Eric O.; Jacobs, Andreas H. 分享 收藏 Assessing the mechanism and therapeutic potential of modulators of the human mediator complex-associated protein kinases CDK8 and CDK19Clarke, Paul A.; Ortiz-Ruiz, Maria-Jesus; Te Poele, Robert; Adeniji-Popoola, Olajumoke; Box, Gary; Esdar, Christina; Ewan, Kenneth; Gowan, Sharon; Brandon, Alexis De Haven; Hewitt, Phllip; Kaufmann, Wolfgang; Mallinger, Aurelie; Raynaud, Florence; Rohdich, Felix; Schiemann, Kai; Simon, Stephanie; Schneider, Richard; Valenti, Melanie; Blagg, Julian; Dale, Trevor; Eccles, Suzanne; Workman, Paul; Wienke, Dirk 分享 收藏 Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinasesClarke, Paul A.; Ortiz-Ruiz, Maria-Jesus; TePoele, Robert; Adeniji-Popoola, Olajumoke; Box, Gary; Court, Will; Czasch, Stephanie; El Bawab, Samer; Esdar, Christina; Ewan, Ken; Gowan, Sharon; Brandon, Alexis De Haven; Hewitt, Phillip; Hobbs, Stephen M.; Kaufmann, Wolfgang; Mallinger, Aurelie; Raynaud, Florence; Roe, Toby; Rohdich, Felix; Schiemann, Kai; Simon, Stephanie; Schneider, Richard; Valenti, Melanie; Weigt, Stefan; Blagg, Julian; Blaukat, Andree; Dale, Trevor C.; Eccles, Suzanne A.; Hecht, Stefan; Urbahns, Klaus; Workman, Paul; Wienke, Dirk 分享 收藏 Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening通过高通量筛选发现的有效，选择性和口服生物利用度CDK8抑制剂的基于结构的优化Czodrowski, Paul; Mallinger, Aurelie; Wienke, Dirk; Esdar, Christina; Poeschke, Oliver; Busch, Michael; Rohdich, Felix; Eccles, Suzanne A.; Ortiz-Ruiz, Maria-Jesus; Schneider, Richard; Raynaud, Florence I.; Clarke, Paul A.; Musil, Djordje; Schwarz, Daniel; Dale, Trevor; Urbahns, Klaus; Blagg, Julian; Schiemann, Kai 分享 收藏 Discovery of preclinical development candidate inhibitors of the mediator complex-associated kinases CDK8 and CDK19 and evaluation of their therapeutic potentialClarke, Paul; Esdar, Christina; Mallinger, Aurelie; Schiemann, Kai; Waalboer, Dennis; Crumpler, Simon; Rink, Christian; Stieber, Frank; Calderini, Michel; Adeniji-Popoola, Olajumoke; Ortiz-Ruiz, Maria-Jesus; Samant, Rahul S.; Czodrowski, Paul; Musil, Djordje; Schwarz, Daniel; Schneider, Klaus; Busch, Michael; Stubbs, Mark; Burke, Rosemary; TePoele, Robert; Gowan, Sharon; Rohdich, Felix; Raynaud, Florence; Schneider, Richard; Poeschke, Oliver; Blaukat, Andree; Urbahns, Klaus; Workman, Paul; Kaufmann, Wolfgang; Simon, Stephanie; Eccles, Suzanne A.; Dale, Trevor; Wienke, Dirk; Blagg, Julian 分享 收藏 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/192，8-二取代的1，6-萘啶和4，6-二取代的异喹啉对CDK8/19具有有效的选择性亲和力Mallinger, Aurelie; Schiemann, Kai; Rink, Christian; Sejberg, Jimmy; Honey, Mark A.; Czodrowski, Paul; Stubbs, Mark; Poeschke, Oliver; Busch, Michael; Schneider, Richard; Schwarz, Daniel; Musil, Djordje; Burke, Rosemary; Urbahns, Klaus; Workman, Paul; Wienke, Dirk; Clarke, Paul A.; Raynaud, Florence I.; Eccles, Suzanne A.; Esdar, Christina; Rohdich, Felix; Blagg, Julian 分享 收藏 分享 收藏 
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