Theodore A. Martinot

merck & company usa

H指数:13

被引数:728

个人简介

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PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2024-07-030

Shepard, Ryan M.; Ghebremedhin, Anghesom; Pratumchai, Isaraphorn; Robinson, Sally R.; Betts, Courtney; Hu, Jingjing; Sasik, Roman; Fisch, Kathleen M.; Zak, Jaroslav; Chen, Hui; Paradise, Marc; Rivera, Jason; Amjad, Mohammad; Uchiyama, Satoshi; Seo, Hideya; Campos, Alejandro D.; Dayao, Denise Ann; Tzipori, Saul; Piedra-Mora, Cesar; Das, Soumita; Hasteh, Farnaz; Russo, Hana; Sun, Xin; Xu, Le; Alexander, Laura Crotty E.; Duran, Jason M.; Odish, Mazen; Pretorius, Victor; Kirchberger, Nell C.; Chin, Shao-ming; Von Schalscha, Tami; Cheresh, David; Morrey, John D.; Alargova, Rossitza; O'Connell, Brenda; Martinot, Theodore A.; Patel, Sandip P.; Nizet, Victor; Martinot, Amanda J.; Coussens, Lisa M.; Teijaro, John R.; Varner, Judith A.

Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-12-0712

PRE

Candito, David A.; Simov, Vladimir; Gulati, Anmol; Kattar, Solomon; Chau, Ryan W.; Lapointe, Blair T.; Methot, Joey L.; DeMong, Duane E.; Graham, Thomas H.; Kurukulasuriya, Ravi; Keylor, Mitchell H.; Tong, Ling; Morriello, Gregori J.; Acton, John J.; Pio, Barbara; Liu, Weiguo; Scott, Jack D.; Ardolino, Michael J.; Martinot, Theodore A.; Maddess, Matthew L.; Yan, Xin; Gunaydin, Hakan; Palte, Rachel L.; McMinn, Spencer E.; Nogle, Lisa; Yu, Hongshi; Minnihan, Ellen C.; Lesburg, Charles A.; Liu, Ping; Su, Jing; Hegde, Laxminarayan G.; Moy, Lily Y.; Woodhouse, Janice D.; Faltus, Robert; Xiong, Tina; Ciaccio, Paul; Piesvaux, Jennifer A.; Otte, Karin M.; Kennedy, Matthew E.; Bennett, David Jonathan; DiMauro, Erin F.; Fell, Matthew J.; Neelamkavil, Santhosh; Wood, Harold B.; Fuller, Peter H.; Ellis, J. Michael

Racemic Synthesis of a Key 1,4-Dihydro-2H-spiro[isoquinoline-3,4′- piperidin]-3′-ol Building Block

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2022-11-080

PRE

Oxetane Promise Delivered: Discovery of Long-Acting IDO1Inhibitors Suitable for Q3W Oral or Parenteral Dosing

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-03-0311

PRE

Li, Derun; Sloman, David L.; Achab, Abdelghani; Zhou, Hua; McGowan, Meredeth A.; White, Catherine; Gibeau, Craig; Zhang, Hongjun; Pu, Qinglin; Bharathan, Indu; Hopkins, Brett; Liu, Kun; Ferguson, Heidi; Fradera, Xavier; Lesburg, Charles A.; Martinot, Theodore A.; Qi, Ji; Song, Zhiguo J.; Yin, Jingjun; Zhang, Huangguang; Song, Licheng; Wan, Baoqiang; DAddio, Suzanne; Solban, Nicolas; Miller, J. Richard; Zamlynny, Beata; Bass, Alan; Freeland, Elizabeth; Ykoruk, Bridget; Hilliard, Catherine; Ferraro, Jude; Zhai, Jin; Knemeyer, Ian; Otte, Karin M.; Vincent, Stella; Sciammetta, Nunzio; Pasternak, Alexander; Bennett, David Jonathan; Han, Yongxin

Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2021-10-139

Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2021-08-186

OAAI

Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2021-02-2617

Li, Derun; Deng, Yongqi; Achab, Abdelghani; Bharathan, Indu; Hopkins, Brett Andrew; Yu, Wensheng; Zhang, Hongjun; Sanyal, Sulagna; Pu, Qinglin; Zhou, Hua; Liu, Kun; Lim, Jongwon; Fradera, Xavier; Lesburg, Charles A.; Lammens, Alfred; Martinot, Theodore A.; Cohen, Ryan D.; Doty, Amy C.; Ferguson, Heidi; Nickbarg, Elliott B.; Cheng, Mangeng; Spacciapoli, Peter; Geda, Prasanthi; Song, Xuelei; Smotrov, Nadya; Abeywickrema, Pravien; Andrews, Christine; Chamberlin, Chad; Mabrouk, Omar; Curran, Patrick; Richards, Matthew; Saradjian, Peter; Miller, J. Richard; Knemeyer, Ian; Otte, Karin M.; Vincent, Stella; Sciammetta, Nunzio; Pasternak, Alexander; Bennett, David Jonathan; Han, Yongxin

Development of a Zinc-Mediated Approach to a 2,3-cis-Pyrrolidine Arginase Inhibitor

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-06-096

PREAI

Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy

合理设计的人精氨酸酶双环抑制剂的发现和优化，以增强癌症免疫治疗

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2020-03-2321

OAAI

Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy