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An orthoflavivirus inhibitor targeting multifunctional NS2A protein, a previously unidentified target 靶向多功能NS2A蛋白的正黄病毒抑制剂，一种此前未被识别的靶点 Borrenberghs, Doortje; Chan, Kitti Wing Ki; Van Brandt, Sven; Jaensch, Steffen; Choy, Milly Ming Ju; Geluykens, Peggy; Bouayadi, Asmae El; Lauwers, Dax; Bist, Pradeep; Stoops, Bart; van de Ven, Jeroen; Vermeulen, Peter; Megens, Sarah; Thys, Kim; Peeters, Danielle; Kaptein, Suzanne J. F.; Neyts, Johan; Vasudevan, Subhash G.; Koul, Anil; Goethals, Olivia 分享 收藏
Phosphoinositide kinase PIKfyve inhibitor apilimod blocks hepatitis E virus infection 磷脂酰肌醇激酶PIKfyve抑制剂apilimod阻断戊型肝炎病毒感染 Ring, Julian J.; Schlienkamp, Sarah; Darido, Maria L. Goussain; Zhang, Xin; Veiga, Olinda Pinto; Haase, Jil Alexandra; Richter, Emely; Goemer, Andre; Fu, Rebecca Menhua; Thi, Viet Loan Dao; Ulrich, Rainer G.; Kloehn, Mara; Todt, Daniel; Bader, Verian; Winklhofer, Konstanze F.; Kinast, Volker; Neyts, Johan; Kaptein, Suzanne J. F.; Steinmann, Eike; Brueggemann, Yannick 分享 收藏
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The tyrosine kinase Yes1 is a druggable host factor of HEV Haase, Jil Alexandra; Baheerathan, Abarna; Zhang, Xin; Fu, Rebecca Menhua; Nocke, Maximilian Klaus; Decker, Charlotte; Thi, Viet Loan Dao; Todt, Daniel; Neyts, Johan; Kaptein, Suzanne J. F.; Steinmann, Eike; Kinast, Volker 分享 收藏
Pan-serotype dengue virus inhibitor JNJ-A07 targets NS4A-2K-NS4B interaction with NS2B/NS3 and blocks replication organelle formation Kiemel, Dominik; Kroell, Ann-Sophie Helene; Denolly, Solene; Haselmann, Uta; Bonfanti, Jean-Francois; Andres, Jose Ignacio; Ghosh, Brahma; Geluykens, Peggy; Kaptein, Suzanne J. F.; Wilken, Lucas; Scaturro, Pietro; Neyts, Johan; Van Loock, Marnix; Goethals, Olivia; Bartenschlager, Ralf 分享 收藏
Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor Kesteleyn, Bart; Bonfanti, Jean-Francois; Bardiot, Dorothee; De Boeck, Benoit; Goethals, Olivia; Kaptein, Suzanne J. F.; Stoops, Bart; Coesemans, Erwin; Fortin, Jerome; Muller, Philippe; Doublet, Frederic; Carlens, Gunter; Koukni, Mohamed; Smets, Wim; Raboisson, Pierre; Chaltin, Patrick; Simmen, Kenny; Van Loock, Marnix; Neyts, Johan; Marchand, Arnaud; Jonckers, Tim H. M. 分享 收藏
Multiplexed multicolor antiviral assay amenable for high-throughput research Li, Li-Hsin; Chiu, Winston; Huang, Yun-An; Rasulova, Madina; Vercruysse, Thomas; Thibaut, Hendrik Jan; ter Horst, Sebastiaan; Rocha-Pereira, Joana; Vanhoof, Greet; Borrenberghs, Doortje; Goethals, Olivia; Kaptein, Suzanne J. F.; Leyssen, Pieter; Neyts, Johan; Dallmeier, Kai 分享 收藏
Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors Kesteleyn, Bart; Bardiot, Dorotheïe; Bonfanti, Jean-Francois; De Boeck, Benoit; Goethals, Olivia; Kaptein, Suzanne J. F.; Stoops, Bart; Coesemans, Erwin; Fortin, Jeïrome; Muller, Philippe; Doublet, Freïdeïric; Carlens, Gunter; Koukni, Mohamed; Smets, Wim; Raboisson, Pierre; Chaltin, Patrick; Simmen, Kenny; Van Loock, Marnix; Neyts, Johan; Marchand, Arnaud; Jonckers, Tim H. M. 分享 收藏
Reverse engineering synthetic antiviral amyloids (vol 11, 2832, 2020) Michiels, Emiel; Roose, Kenny; Gallardo, Rodrigo; Khodaparast, Ladan; Khodaparast, Laleh; van der Kant, Rob; Siemons, Maxime; Houben, Bert; Ramakers, Meine; Wilkinson, Hannah; Guerreiro, Patricia; Louros, Nikolaos; Kaptein, Suzanne J. F.; Ibanez, Lorena Itati; Smet, Anouk; Baatsen, Pieter; Liu, Shu; Vorberg, Ina; Bormans, Guy; Neyts, Johan; Saelens, Xavier; Rousseau, Frederic; Schymkowitz, Joost 分享 收藏
Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro Radoshitzky, Sheli R.; Iversen, Patrick; Lu, Xianghan; Zou, Jing; Kaptein, Suzanne J. F.; Stuthman, Kelly S.; Van Tongeren, Sean A.; Steffens, Jesse; Gong, Ruoyu; Truong, Hoa; Sapre, Annapurna A.; Yang, Huiling; Xie, Xiaodong; Chia, Jia Jun; Song, Zhijuan J.; Leventhal, Stacey M.; Chan, Josolyn; Shornikov, Alex; Zhang, Xin; Cowfer, David; Yu, Helen; Warren, Travis; Cihlar, Tomas; Porter, Danielle P.; Neyts, Johan; Shi, Pei-Yong; Wells, Jay; Bilello, John P.; Feng, Joy Y. 分享 收藏
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An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models Schepens, Bert; van Schie, Loes; Nerinckx, Wim; Roose, Kenny; Van Breedam, Wander; Fijalkowska, Daria; Devos, Simon; Weyts, Wannes; De Cae, Sieglinde; Vanmarcke, Sandrine; Lonigro, Chiara; Eeckhaut, Hannah; Van Herpe, Dries; Borloo, Jimmy; Oliveira, Ana Filipa; Catani, Joao Paulo Portela; Creytens, Sarah; De Vlieger, Dorien; Michielsen, Gitte; Marchan, Jackeline Cecilia Zavala; Moschonas, George D.; Rossey, Iebe; Sedeyn, Koen; Van Hecke, Annelies; Zhang, Xin; Langendries, Lana; Jacobs, Sofie; Ter Horst, Sebastiaan; Seldeslachts, Laura; Liesenborghs, Laurens; Boudewijns, Robbert; Thibaut, Hendrik Jan; Dallmeier, Kai; Vande Velde, Greetje; Weynand, Birgit; Beer, Julius; Schnepf, Daniel; Ohnemus, Annette; Remory, Isabel; Foo, Caroline S.; Abdelnabi, Rana; Maes, Piet; Kaptein, Suzanne J. F.; Rocha-Pereira, Joana; Jochmans, Dirk; Delang, Leen; Peelman, Frank; Staeheli, Peter; Schwemmle, Martin; Devoogdt, Nick; Tersago, Dominique; Germani, Massimiliano; Heads, James; Henry, Alistair; Popplewell, Andrew; Ellis, Mark; Brady, Kevin; Turner, Alison; Dombrecht, Bruno; Stortelers, Catelijne; Neyts, Johan; Callewaert, Nico; Saelens, Xavier 分享 收藏
The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model Abdelnabi, Rana; Foo, Caroline S.; Kaptein, Suzanne J. F.; Zhang, Xin; Do, Thuc Nguyen Dan; Langendries, Lana; Vangeel, Laura; Breuer, Judith; Pang, Juanita; Williams, Rachel; Vergote, Valentijn; Heylen, Elisabeth; Leyssen, Pieter; Dallmeier, Kai; Coelmont, Lotte; Chatterjee, Arnab K.; Mols, Raf; Augustijns, Patrick; De Jonghe, Steven; Jochmans, Dirk; Weynand, Birgit; Neyts, Johan 分享 收藏
itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens (vol 66, 103288, 2021) Liesenborghs, Laurens; Spriet, Isabel; Jochmans, Dirk; Belmans, Ann; Gyselinck, Iwein; Teuwen, Laure-Anne; ter Horst, Sebastiaan; Dreesen, Erwin; Geukens, Tatjana; Engelen, Matthias M.; Landeloos, Ewout; Geldhof, Vincent; Ceunen, Helga; Debaveye, Barbara; Vandenberk, Bert; Van der Linden, Lorenz; Jacobs, Sofie; Langendries, Lana; Boudewijns, Robbert; Do, Thuc Nguyen Dan; Chiu, Winston; Wang, Xinyu; Zhang, Xin; Weynand, Birgit; Vanassche, Thomas; Devos, Timothy; Meyfroidt, Geert; Janssens, Wim; Vos, Robin; Vermeersch, Pieter; Wauters, Joost; Verbeke, Geert; De Munter, Paul; Kaptein, Suzanne J. F.; Rocha-Pereira, Joana; Delang, Leen; Van Wijngaerden, Eric; Neyts, Johan; Verhamme, Peter 分享 收藏
Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters Abdelnabi, Rana; Boudewijns, Robbert; Foo, Caroline S.; Seldeslachts, Laura; Sanchez-Felipe, Lorena; Zhang, Xin; Delang, Leen; Maes, Piet; Kaptein, Suzanne J. F.; Weynand, Birgit; Vande Velde, Greetje; Neyts, Johan; Dallmeier, Kai 分享 收藏
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