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G

Glenn Sivits

Amgen
H指数:14
被引数:2,189

个人简介

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教育背景

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工作经历

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荣誉奖项

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GIPR-Ab/GLP-1 peptide-antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice

GIPR-Ab/GLP-1肽-抗体偶联物在肥胖小鼠中需要脑部GIPR和GLP-1R以实现加性体重减轻

NATURE METABOLISM
IF20.8
2025-04-292
OA
Liu, Clarissa M.; Killion, Elizabeth A.; Hammoud, Rola; Lu, Shu-Chen; Komorowski, Renee; Liu, Tongyu; Kanke, Matt; Thomas, Veena A.; Cook, Kevin; Sivits Jr, Glenn N.; Ben, Aerielle B.; Atangan, Larissa I.; Hussien, Rajaa; Tang, Amy; Shkumatov, Artem; Li, Chi-Ming; Drucker, Daniel J.; Veniant, Murielle M.
Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2018-12-19157
OAAI
Killion, Elizabeth A.; Wang, Jinghong; Yie, Junming; Shi, Stone D. -H.; Bates, Darren; Min, Xiaoshan; Komorowski, Renee; Hager, Todd; Deng, Liying; Atangan, Larissa; Lu, Shu-Chen; Kurzeja, Robert J. M.; Sivits, Glenn; Lin, Joanne; Chen, Qing; Wang, Zhulun; Thibault, Stephen A.; Abbott, Christina M.; Meng, Tina; Clavette, Brandon; Murawsky, Christopher M.; Foltz, Ian N.; Rottman, James B.; Hale, Clarence; Veniant, Murielle M.; Lloyd, David J.
Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational Constraint
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2015-12-0136
OAAI
Pennington, Lewis D.; Bartberger, Michael D.; Croghan, Michael D.; Andrews, Kristin L.; Ashton, Kate S.; Bourbeau, Matthew P.; Chen, Jie; Chmait, Samer; Cupples, Rod; Fotsch, Christopher; Helmering, Joan; Hong, Fang-Tsao; Hungate, Randall W.; Jordan, Steven R.; Kong, Ke; Liu, Longbin; Michelsen, Klaus; Moyer, Carolyn; Nishimura, Nobuko; Norman, Mark H.; Reichelt, Andreas; Siegmund, Aaron C.; Sivits, Glenn; Tadesse, Seifu; Tegley, Christopher M.; Van, Gwyneth; Yang, Kevin C.; Yao, Guomin; Zhang, Jiandong; Lloyd, David J.; Hale, Clarence; St Jean, David J., Jr.
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2015-06-0125
PREAI
Tamayo, Nuria A.; Norman, Mark H.; Bartberger, Michael D.; Hong, Fang-Tsao; Bo, Yunxin; Liu, Longbin; Nishimura, Nobuko; Yang, Kevin C.; Tadesse, Seifu; Fotsch, Christopher; Chen, Jie; Chmait, Samer; Cupples, Rod; Hale, Clarence; Jordan, Steven R.; Lloyd, David J.; Sivits, Glenn; Van, Gwyneth; Jean, David J. St., Jr.
Small Molecule Disruptors of the Glucokinase Glucokinase Regulatory Protein Interaction: 3. Structure Activity Relationships within the Aryl Carbinol Region of the N-Arylsulfonamido-N'-arylpiperazine Series
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-03-3155
PREAI
Nishimura, Nobuko; Norman, Mark H.; Liu, Longbin; Yang, Kevin C.; Ashton, Kate S.; Bartberger, Michael D.; Chmait, Samer; Chen, Jie; Cupples, Rod; Fotsch, Christopher; Helmering, Joan; Jordan, Steven R.; Kunz, Roxanne K.; Pennington, Lewis D.; Poon, Steve F.; Siegmund, Aaron; Sivits, Glenn; Lloyd, David J.; Hale, Clarence; St Jean, David J., Jr.
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept (vol 57, pg 309, 2014)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-02-280
PREAI
Ashton, Kate S.; Andrews, Kristin L.; Bryan, Marian C.; Chen, Jie; Chen, Kui; Chen, Michelle; Chmait, Samer; Croghan, Michael; Cupples, Rod; Fotsch, Christopher; Helmering, Joan; Jordan, Steve R.; Kurzeja, Robert J. M.; Michelsen, Klaus; Pennington, Lewis D.; Poon, Steve F.; Sivits, Glenn; Van, Gwyneth; Vonderfecht, Steve L.; Wahl, Robert C.; Zhang, Jiandong; Lloyd, David J.; Hale, Clarence; St. Jean, David J., Jr.
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinetic Profiles
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-01-0922
PREAI
St Jean, David J., Jr.; Ashton, Kate S.; Bartberger, Michael D.; Chen, Jie; Chmait, Samer; Cupples, Rod; Galbreath, Elizabeth; Helmering, Joan; Hong, Fang-Tsao; Jordan, Steven R.; Liu, Longbin; Kunz, Roxanne K.; Michelsen, Klaus; Nishimura, Nobuko; Pennington, Lewis D.; Poon, Steve F.; Reid, Darren; Sivits, Glenn; Stec, Markian M.; Tadesse, Seifu; Tamayo, Nuria; Van, Gwyneth; Yang, Kevin C.; Zhang, Jiandong; Norman, Mark H.; Fotsch, Christopher; Lloyd, David J.; Hale, Clarence
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-01-0936
PREAI
Ashton, Kate S.; Andrews, Kristin L.; Bryan, Marion C.; Chen, Jie; Chen, Kui; Chen, Michelle; Chmait, Samer; Croghan, Michael; Cupples, Rod; Fotsch, Christopher; Helmering, Joan; Jordan, Steve R.; Kurzeja, Robert J. M.; Michelsen, Klaus; Pennington, Lewis D.; Poon, Steve F.; Sivits, Glenn; Van, Gwyneth; Vonderfecht, Steve L.; Wahl, Robert C.; Zhang, Jiandong; Lloyd, David J.; Hale, Clarence; St Jean, David J., Jr.
Long-Term Inhibition of the Glucagon Receptor with a Monoclonal Antibody in Mice Causes Sustained Improvement in Glycemic Control, with Reversible α-Cell Hyperplasia and Hyperglucagonemia
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
2009-12-01100
PREAI
Gu, Wei; Yan, Hai; Winters, Katherine A.; Komorowski, Renee; Vonderfecht, Steven; Atangan, Larissa; Sivits, Glenn; Hill, David; Yang, Jie; Bi, Vivian; Shen, Yuqing; Hu, Sylvia; Boone, Tom; Lindberg, Richard A.; Veniant, Murielle M.

研究方向

暂未获取到该数据
D
David J. Lloyd
H 指数:37论文数:145被引数:6,492
C
Clarence Hale
H 指数:33论文数:74被引数:4,300
C
Christopher Fotsch
H 指数:31论文数:79被引数:2,890
J
Jie Chen
H 指数:20论文数:78被引数:1,315
D
David J. St. Jean
H 指数:22论文数:64被引数:1,479
S
Samer Chmait
H 指数:15论文数:42被引数:558
R
Rod Cupples
H 指数:24论文数:45被引数:4,779
M
Murielle M. Véniant
H 指数:50论文数:118被引数:8,928
J
Joan Helmering
H 指数:13论文数:29被引数:876
K
Kate S. Ashton
H 指数:12论文数:34被引数:1,159