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C

Christopher Fotsch

Amgen
H指数:31
被引数:2,890

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荣誉奖项

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Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase
ACS CHEMICAL BIOLOGY
IF3.8
2016-08-1158
OAAI
Allen, John G.; Mujacic, Mirna; Frohn, Michael J.; Pickrell, Alex J.; Kodama, Paul; Baga, Dhanashri; San Miguel, Tisha; Sickmier, E. Allen; Osgood, Steve; Swietlow, Aleksander; Li, Vivian; Jordan, John B.; Kim, Ki-Won; Rousseau, Anne-Marie C.; Kirn, Yong-Jae; Caille, Seb; Achmatowicz, Mike; Thiel, Oliver; Fotsch, Christopher H.; Reddy, Pranhitha; McCarter, John D.
Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational Constraint
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2015-12-0136
OAAI
Pennington, Lewis D.; Bartberger, Michael D.; Croghan, Michael D.; Andrews, Kristin L.; Ashton, Kate S.; Bourbeau, Matthew P.; Chen, Jie; Chmait, Samer; Cupples, Rod; Fotsch, Christopher; Helmering, Joan; Hong, Fang-Tsao; Hungate, Randall W.; Jordan, Steven R.; Kong, Ke; Liu, Longbin; Michelsen, Klaus; Moyer, Carolyn; Nishimura, Nobuko; Norman, Mark H.; Reichelt, Andreas; Siegmund, Aaron C.; Sivits, Glenn; Tadesse, Seifu; Tegley, Christopher M.; Van, Gwyneth; Yang, Kevin C.; Yao, Guomin; Zhang, Jiandong; Lloyd, David J.; Hale, Clarence; St Jean, David J., Jr.
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2015-06-0125
PREAI
Tamayo, Nuria A.; Norman, Mark H.; Bartberger, Michael D.; Hong, Fang-Tsao; Bo, Yunxin; Liu, Longbin; Nishimura, Nobuko; Yang, Kevin C.; Tadesse, Seifu; Fotsch, Christopher; Chen, Jie; Chmait, Samer; Cupples, Rod; Hale, Clarence; Jordan, Steven R.; Lloyd, David J.; Sivits, Glenn; Van, Gwyneth; Jean, David J. St., Jr.
Small Molecule Disruptors of the Glucokinase Glucokinase Regulatory Protein Interaction: 3. Structure Activity Relationships within the Aryl Carbinol Region of the N-Arylsulfonamido-N'-arylpiperazine Series
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-03-3155
PREAI
Nishimura, Nobuko; Norman, Mark H.; Liu, Longbin; Yang, Kevin C.; Ashton, Kate S.; Bartberger, Michael D.; Chmait, Samer; Chen, Jie; Cupples, Rod; Fotsch, Christopher; Helmering, Joan; Jordan, Steven R.; Kunz, Roxanne K.; Pennington, Lewis D.; Poon, Steve F.; Siegmund, Aaron; Sivits, Glenn; Lloyd, David J.; Hale, Clarence; St Jean, David J., Jr.
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept (vol 57, pg 309, 2014)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-02-280
PREAI
Ashton, Kate S.; Andrews, Kristin L.; Bryan, Marian C.; Chen, Jie; Chen, Kui; Chen, Michelle; Chmait, Samer; Croghan, Michael; Cupples, Rod; Fotsch, Christopher; Helmering, Joan; Jordan, Steve R.; Kurzeja, Robert J. M.; Michelsen, Klaus; Pennington, Lewis D.; Poon, Steve F.; Sivits, Glenn; Van, Gwyneth; Vonderfecht, Steve L.; Wahl, Robert C.; Zhang, Jiandong; Lloyd, David J.; Hale, Clarence; St. Jean, David J., Jr.
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinetic Profiles
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-01-0922
PREAI
St Jean, David J., Jr.; Ashton, Kate S.; Bartberger, Michael D.; Chen, Jie; Chmait, Samer; Cupples, Rod; Galbreath, Elizabeth; Helmering, Joan; Hong, Fang-Tsao; Jordan, Steven R.; Liu, Longbin; Kunz, Roxanne K.; Michelsen, Klaus; Nishimura, Nobuko; Pennington, Lewis D.; Poon, Steve F.; Reid, Darren; Sivits, Glenn; Stec, Markian M.; Tadesse, Seifu; Tamayo, Nuria; Van, Gwyneth; Yang, Kevin C.; Zhang, Jiandong; Norman, Mark H.; Fotsch, Christopher; Lloyd, David J.; Hale, Clarence
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-01-0936
PREAI
Ashton, Kate S.; Andrews, Kristin L.; Bryan, Marion C.; Chen, Jie; Chen, Kui; Chen, Michelle; Chmait, Samer; Croghan, Michael; Cupples, Rod; Fotsch, Christopher; Helmering, Joan; Jordan, Steve R.; Kurzeja, Robert J. M.; Michelsen, Klaus; Pennington, Lewis D.; Poon, Steve F.; Sivits, Glenn; Van, Gwyneth; Vonderfecht, Steve L.; Wahl, Robert C.; Zhang, Jiandong; Lloyd, David J.; Hale, Clarence; St Jean, David J., Jr.
4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2011-08-0220
OAAI
Pennington, Lewis D.; Sham, Kelvin K. C.; Pickrell, Alexander J.; Harrington, Paul E.; Frohn, Michael J.; Lanman, Brian A.; Reed, Anthony B.; Croghan, Michael D.; Lee, Matthew R.; Xu, Han; McElvain, Michele; Xu, Yang; Zhang, Xuxia; Fiorino, Michael; Horner, Michelle; Morrison, Henry G.; Arnett, Heather A.; Fotsch, Christopher; Wong, Min; Cee, Victor J.
Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (S)-2-(1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2010-05-1374
PREAI
Veniant, Murielle M.; Hale, Clarence; Hungate, Randall W.; Gahm, Kyung; Emery, Maurice G.; Jona, Janan; Joseph, Smriti; Adams, Jeffrey; Hague, Andrew; Moniz, George; Zhang, Jiandong; Bartberger, Michael D.; Li, Vivian; Syed, Rashid; Jordan, Steven; Komorowski, Renee; Chen, Michelle M.; Cupples, Rod; Kim, Ki Won; St Jean, David J., Jr.; Johansson, Lars; Henriksson, Martin A.; Williams, Meredith; Vallgarda, Jerk; Fotsch, Christopher; Wang, Minghan
Cytochrome P450-Mediated Epoxidation of 2-Aminothiazole-Based AKT Inhibitors: Identification of Novel GSH Adducts and Reduction of Metabolic Activation through Structural Changes Guided by in Silico and in Vitro Screening
CHEMICAL RESEARCH IN TOXICOLOGY
IF3.8
2010-01-2229
PREAI
Subramanian, Raju; Lee, Matthew R.; Allen, John G.; Bourbeau, Matthew P.; Fotsch, Christopher; Hong, Fang-Tsao; Tadesse, Seifu; Yao, Guomin; Yuan, Chester C.; Surapaneni, Sekhar; Skiles, Gary L.; Wang, Xianghong; Wohlhieter, G. Erich; Zeng, Qingping; Zhou, Yihong; Zhu, Xiaochun; Li, Chun

研究方向

暂未获取到该数据
C
Clarence Hale
H 指数:33论文数:74被引数:4,300
D
David J. St. Jean
H 指数:22论文数:64被引数:1,479
M
Mark H. Norman
H 指数:40论文数:111被引数:5,364
M
Michael D. Bartberger
H 指数:45论文数:134被引数:8,320
R
Rod Cupples
H 指数:24论文数:45被引数:4,779
M
Murielle M. Véniant
H 指数:50论文数:118被引数:8,928
M
Minghan Wang
H 指数:34论文数:297被引数:4,757
M
Michelle Chen
H 指数:40论文数:250被引数:5,461
D
David J. Lloyd
H 指数:37论文数:145被引数:6,492
G
Glenn Sivits
H 指数:14论文数:17被引数:2,189