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C

Clarence Hale

Amgen
H指数:33
被引数:4,302

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荣誉奖项

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Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2018-12-19157
OAAI
Killion, Elizabeth A.; Wang, Jinghong; Yie, Junming; Shi, Stone D. -H.; Bates, Darren; Min, Xiaoshan; Komorowski, Renee; Hager, Todd; Deng, Liying; Atangan, Larissa; Lu, Shu-Chen; Kurzeja, Robert J. M.; Sivits, Glenn; Lin, Joanne; Chen, Qing; Wang, Zhulun; Thibault, Stephen A.; Abbott, Christina M.; Meng, Tina; Clavette, Brandon; Murawsky, Christopher M.; Foltz, Ian N.; Rottman, James B.; Hale, Clarence; Veniant, Murielle M.; Lloyd, David J.
Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational Constraint
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2015-12-0136
OAAI
Pennington, Lewis D.; Bartberger, Michael D.; Croghan, Michael D.; Andrews, Kristin L.; Ashton, Kate S.; Bourbeau, Matthew P.; Chen, Jie; Chmait, Samer; Cupples, Rod; Fotsch, Christopher; Helmering, Joan; Hong, Fang-Tsao; Hungate, Randall W.; Jordan, Steven R.; Kong, Ke; Liu, Longbin; Michelsen, Klaus; Moyer, Carolyn; Nishimura, Nobuko; Norman, Mark H.; Reichelt, Andreas; Siegmund, Aaron C.; Sivits, Glenn; Tadesse, Seifu; Tegley, Christopher M.; Van, Gwyneth; Yang, Kevin C.; Yao, Guomin; Zhang, Jiandong; Lloyd, David J.; Hale, Clarence; St Jean, David J., Jr.
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2015-06-0125
PREAI
Tamayo, Nuria A.; Norman, Mark H.; Bartberger, Michael D.; Hong, Fang-Tsao; Bo, Yunxin; Liu, Longbin; Nishimura, Nobuko; Yang, Kevin C.; Tadesse, Seifu; Fotsch, Christopher; Chen, Jie; Chmait, Samer; Cupples, Rod; Hale, Clarence; Jordan, Steven R.; Lloyd, David J.; Sivits, Glenn; Van, Gwyneth; Jean, David J. St., Jr.
Small Molecule Disruptors of the Glucokinase Glucokinase Regulatory Protein Interaction: 3. Structure Activity Relationships within the Aryl Carbinol Region of the N-Arylsulfonamido-N'-arylpiperazine Series
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-03-3155
PREAI
Nishimura, Nobuko; Norman, Mark H.; Liu, Longbin; Yang, Kevin C.; Ashton, Kate S.; Bartberger, Michael D.; Chmait, Samer; Chen, Jie; Cupples, Rod; Fotsch, Christopher; Helmering, Joan; Jordan, Steven R.; Kunz, Roxanne K.; Pennington, Lewis D.; Poon, Steve F.; Siegmund, Aaron; Sivits, Glenn; Lloyd, David J.; Hale, Clarence; St Jean, David J., Jr.
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept (vol 57, pg 309, 2014)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-02-280
PREAI
Ashton, Kate S.; Andrews, Kristin L.; Bryan, Marian C.; Chen, Jie; Chen, Kui; Chen, Michelle; Chmait, Samer; Croghan, Michael; Cupples, Rod; Fotsch, Christopher; Helmering, Joan; Jordan, Steve R.; Kurzeja, Robert J. M.; Michelsen, Klaus; Pennington, Lewis D.; Poon, Steve F.; Sivits, Glenn; Van, Gwyneth; Vonderfecht, Steve L.; Wahl, Robert C.; Zhang, Jiandong; Lloyd, David J.; Hale, Clarence; St. Jean, David J., Jr.
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinetic Profiles
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-01-0922
PREAI
St Jean, David J., Jr.; Ashton, Kate S.; Bartberger, Michael D.; Chen, Jie; Chmait, Samer; Cupples, Rod; Galbreath, Elizabeth; Helmering, Joan; Hong, Fang-Tsao; Jordan, Steven R.; Liu, Longbin; Kunz, Roxanne K.; Michelsen, Klaus; Nishimura, Nobuko; Pennington, Lewis D.; Poon, Steve F.; Reid, Darren; Sivits, Glenn; Stec, Markian M.; Tadesse, Seifu; Tamayo, Nuria; Van, Gwyneth; Yang, Kevin C.; Zhang, Jiandong; Norman, Mark H.; Fotsch, Christopher; Lloyd, David J.; Hale, Clarence
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-01-0936
PREAI
Ashton, Kate S.; Andrews, Kristin L.; Bryan, Marion C.; Chen, Jie; Chen, Kui; Chen, Michelle; Chmait, Samer; Croghan, Michael; Cupples, Rod; Fotsch, Christopher; Helmering, Joan; Jordan, Steve R.; Kurzeja, Robert J. M.; Michelsen, Klaus; Pennington, Lewis D.; Poon, Steve F.; Sivits, Glenn; Van, Gwyneth; Vonderfecht, Steve L.; Wahl, Robert C.; Zhang, Jiandong; Lloyd, David J.; Hale, Clarence; St Jean, David J., Jr.
Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (S)-2-(1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2010-05-1374
PREAI
Veniant, Murielle M.; Hale, Clarence; Hungate, Randall W.; Gahm, Kyung; Emery, Maurice G.; Jona, Janan; Joseph, Smriti; Adams, Jeffrey; Hague, Andrew; Moniz, George; Zhang, Jiandong; Bartberger, Michael D.; Li, Vivian; Syed, Rashid; Jordan, Steven; Komorowski, Renee; Chen, Michelle M.; Cupples, Rod; Kim, Ki Won; St Jean, David J., Jr.; Johansson, Lars; Henriksson, Martin A.; Williams, Meredith; Vallgarda, Jerk; Fotsch, Christopher; Wang, Minghan
Further Studies with the 2-Amino-1,3-thiazol-4(5H)-one Class of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Reducing Pregnane X Receptor Activity and Exploring Activity in a Monkey Pharmacodynamic Model
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2008-11-1931
PREAI
Fotsch, Christopher; Bartberger, Michael D.; Bercot, Eric A.; Chen, Michelle; Cupples, Rod; Emery, Maury; Fretland, Jenne; Guram, Anil; Hale, Clarence; Han, Nianhe; Hickman, Dean; Hungate, Randall W.; Hayashi, Michael; Konlorowski, Renee; Liu, Qingyian; Matsumoto, Guy; Jean, David J. St.; Ursu, Stefania; Veniant, Murielle; Xu, Guifen; Ye, Qiuping; Yuan, Chester; Zhang, Jiandong; Zhang, Xiping; Tu, Hua; Wang, Minghan

研究方向

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C
Christopher Fotsch
H 指数:31论文数:79被引数:2,892
M
Murielle M. Véniant
H 指数:50论文数:118被引数:8,937
D
David J. St. Jean
H 指数:22论文数:64被引数:1,480
D
David J. Lloyd
H 指数:37论文数:145被引数:6,498
R
Rod Cupples
H 指数:24论文数:45被引数:4,779
M
Michelle Chen
H 指数:40论文数:250被引数:5,482
G
Glenn Sivits
H 指数:14论文数:17被引数:2,193
M
Minghan Wang
H 指数:34论文数:297被引数:4,762
M
Mark H. Norman
H 指数:40论文数:111被引数:5,366
M
Michael D. Bartberger
H 指数:45论文数:134被引数:8,325