Pablo Umaña - Publications, H-index & Citations

Pablo Umaña

roche

51H指数

542论文数

1.2W被引数

收录论文 107

发表时间

Target receptor expression dictates the selective intra-tumoral targeting of CD8+ T cells by eciskafusp alfa in matched PBMCs and TILs from CPI-naïve patients 靶受体表达决定了在CPI-naïve患者的配对PBMCs和TILs中，eciskafusp alfa对CD8+ T细胞的肿瘤内选择性靶向

Frontiers in Immunology

IF5.9

2026-06-01

OAAI

AM Amrita Manchala †; EM Eleni Maria Varypataki †; JC Jehad Charo; PU Pablo Umaña; CK Christian Klein; LC Laura Codarri Deak

Cibisatamab and FAP-4-1BBL in microsatellite-stable colorectal cancer: a phase 1b trial 西比萨他马贝和FAP-4-1BBL在微卫星稳定型结直肠癌中的研究：一项1b期临床试验

Nature Medicine

IF50

2026-04-20

OAAI

Ignacio Melero; Tamara Tanos; Emiliano Calvo Aller; Camilla Qvortrup; Marloes van Dongen; Iosune Baraibar; Seung-Hoon Beom; Fiona Thistlethwaite; Maria del Carmen Riesco; Maria Martinez Garcia; Victoria Woodcock; Tae Won Kim; Pablo Umana; Christine McIntyre; Lining Chen; Christian Heichinger; Heather Hinton; Tulun Saylan; Iakov I. Davydov; Ernesto Guarin; Axel Boehnke; Victor Moreno

CEA-4-1BBL: CEACAM5-Targeted 4-1BB Ligand Fusion Proteins for Cis Co-Stimulation with CEA-TCB CEA-4-1BBL: 靶向CEACAM5的4-1BB配体融合蛋白，用于与CEA-TCB的顺式协同刺激

Antibodies

IF2.7

2026-03-03

OAAI

Christina Claus; Claudia Ferrara-Koller; Johannes Sam; Sabine Lang; Rosmarie Albrecht; Regula B. Buser; Esther Bommer; Grégory La Sala; Valeria G. Nicolini; Sara Colombetti; Marina Bacac; Pablo Umaña; Christian Klein

PD1-IL2v expands and induces effector CD8+ TILs, but not Tregs, in the BCG treated orthotopic non-muscle invasive bladder cancer model PD1-IL2v能够扩增并诱导同源非肌层浸润性膀胱癌模型中经BCG处理的效应性CD8+ TILs，但不诱导Tregs。

Journal of Experimental & Clinical Cancer Research

IF12.8

2026-02-11

OAAI

Irene Locatelli; Marco Lorenzoni; Chiara Venegoni; Alessia Di Coste; Rita Sorrentino; Jithin Jose; Daniela Maria Cirillo; Patrick Weber; Amrita Manchala; Ralf J. Hosse; Valeria Nicolini; Pablo Umana; Christian Klein; Andrea Salonia; Francesco Montorsi; Matteo Bellone; Marco Moschini; Laura Codarri Deak; Massimo Alfano

Molecular Features of Response and Resistance to Glofitamab, a T-Cell Engager for treatment of Large B-Cell Lymphoma

Blood Advances

IF7.1

2026-01-27

OAAI

Stephan Schmeing; Sina Nassiri; Gabrielle Leclercq-Cohen; Emilio Yángüez; Tamara Hüsser; Llucia Alberti Servera; Ramona Schlenker; Johannes Sam; Christian Klein; Pablo Umana; Sylvia Herter; Alessia Bottos; Marina Bacac

P329G-engager: a universal mix & match antibody-based adaptor platform for cancer immunotherapy

MABS

IF7.3

2026-01-22

PREAI

Surowka, Marlena; Darowski, Diana; Hutter-Karakoc, Idil; Claus, Christina; Ferrara-Koller, Claudia; Freimoser-Grundschober, Anne; Hofer, Thomas; Sam, Johannes; Gianotti, Reto; Sobieniecki, Andrzej; Assisi, Denis; Challier, John; Leclair, Stephane; Mossner, Ekkehard; Amann, Maria; Umana, Pablo; Klein, Christian

PD-1–targeted cis-delivery of an IL-2 variant induces a multifaceted antitumoral T cell response in human lung cancer PD-1靶向的同向递送IL-2变体在人类肺癌中诱导了多方面的抗肿瘤T细胞反应

Science Translational Medicine

IF14.6

2025-09-17

PREAI

Irene Fusi; Clara Serger; Petra Herzig; Markus Germann; Michael T. Sandholzer1; Nicole Oelgarth1; Petra C. Schwalie; Leyla Don; Viola K. Vetter; Viktor H. Koelzer; Didier Lardinois; Henry Kao; Laura Codarri Deak; Pablo Umaña; Christian Klein; Aljaz Hojski; Marina Natoli; Alfred Zippelius

Chronic antigen stimulation in melanoma induces T cell exhaustion and limits efficacy of T cell bispecific therapies 黑色素瘤中的慢性抗原刺激诱导T细胞耗竭并限制T细胞双特异性疗法的疗效

OncoImmunology

IF6.3

2025-08-26

OAAI

Idil Hutter-Karakoc; Eleni Maria Varypataki; Aparna Neelakandhan; Simone Lang; Vesna Kramar; Ahmet Varol; Sasha Simons; Marine Richard; Mudita Pincha; Dario Venetz; Johannes Sam; Nicole Joller; Christian Münz; Pablo Umana; Christian Klein; Maria Amann

Preclinical advances in glofitamab combinations: a new frontier for Non-Hodgkin Lymphoma glofitamab组合的预临床进展：非霍奇金淋巴瘤的新前沿

Blood

IF23.1

2025-08-05

OAAI

Johannes Sam; Gabrielle Leclercq-Cohen; Samuel Gebhardt; Marlena Surowka; Sylvia Herter; Katharina Lechner; James Relf; Stefanie Briner; Ahmet Varol; Birte Appelt; Ioana Domocos; Valeria Nicolini; Miriam Bez; Esther Bommer; Silvia Jenni; Anne Schoenle; Marine Le Clech; Sara Colombetti; Christian Klein; Pablo Umaña; Pontus Lundberg; Koorosh Korfi; Alessia Bottos; Marina Bacac

4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models 靶向纤维细胞活化蛋白α的4-1BB激动剂与放射疗法协同作用以治疗小鼠乳腺癌模型

JOURNAL FOR IMMUNOTHERAPY OF CANCER

IF10.6

2025-02-11

OAAI

Garate-Soraluze, Eneko; Serrano-Mendioroz, Irantzu; Fernandez-Rubio, Leticia; De Andrea, Carlos E.; Barrio-Alonso, Celia; Herrero, Claudia del Pilar; Teijeira, Alvaro; Luri-Rey, Carlos; Claus, Christina; Tanos, Tamara; Klein, Christian; Umana, Pablo; Rullan, Antonio; Simon, Jon Ander; Collantes, Maria; Sanchez-Mateos, Paloma; Melero, Ignacio; Rodriguez-Ruiz, Maria E.

T cell margination: investigating the detour of T cells following forimtamig treatment in humanized mice T细胞边缘: 在人源化小鼠中研究forimtamig治疗后T细胞的绕行

MABS

IF7.3

2024-12-16

OAAI

O'Brien, Nils; Mueller, Joerg P. J.; Broeske, Ann-Marie E.; Attig, Jan; Osl, Franz; Crisand, Cylia; Wolf, Ann-Katrin; Rae, Richard; Lechner, Stefanie; Poeschinger, Thomas; Klein, Christian; Umana, Pablo; Colombetti, Sara; Beilhack, Andreas; Eckmann, Jan

Myeloid-T cell interplay and cell state transitions associated with checkpoint inhibitor response in melanoma

MED

IF11.8

2024-07-01

OAAI

Schlenker, Ramona; Schwalie, Petra C.; Dettling, Steffen; Huesser, Tamara; Irmisch, Anja; Mariani, Marisa; Gomez, Julia M. Martinez; Ribeiro, Alison; Limani, Florian; Herter, Sylvia; Yanguez, Emilio; Hoves, Sabine; Somandin, Jitka; Siebourg-Polster, Juliane; Kam-Thong, Tony; Matos, Ines Grazina de; Umana, Pablo; Dummer, Reinhard; Levesque, Mitchell P.; Bacac, Marina

The physiological interactome of TCR-like antibody therapeutics in human tissues

NATURE COMMUNICATIONS

IF15.7

2024-04-16

OAAI

Marrer-Berger, Estelle; Nicastri, Annalisa; Augustin, Angelique; Kramar, Vesna; Liao, Hanqing; Hanisch, Lydia Jasmin; Carpy, Alejandro; Weinzierl, Tina; Durr, Evelyne; Schaub, Nathalie; Nudischer, Ramona; Ortiz-Franyuti, Daniela; Breous-Nystrom, Ekaterina; Stucki, Janick; Hobi, Nina; Raggi, Giulia; Cabon, Lauriane; Lezan, Emmanuelle; Umana, Pablo; Woodhouse, Isaac; Bujotzek, Alexander; Klein, Christian; Ternette, Nicola

P329G-Engager: A novel universal antibody-based adaptor platform for cancer immunotherapy

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Surowka, Marlena; Hutter-Karakoc, Idil; Darowski, Diana; Claus, Christina; Koller, Claudia Ferrara; Freimoser-Grundschober, Anne; Hofer, Thomas; Sobieniecki, Andrzej; Assisi, Denis; Leclair, Stephane; Moessner, Ekkehard; Umana, Pablo; Amann, Maria; Klein, Christian

Combined light sheet and multispectral imaging facilitates the detection of tumor-associated tertiary lymphoid structures in the KP NSCLC model

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

O'Brien, Nils; Appelt, Birte; Moerbitz, Marie-Lena; Mueller, Joerg P.; Herting, Frank; Umana, Pablo; Murgia, Claudio; Colombetti, Sara; Poschinger, Thomas

Tobemstomig, a novel bispecific checkpoint inhibitory antibody to preferentially block PD-1 and LAG-3 on CD8 TILs over Tregs

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Codarri-Deak, Laura; Weber, Patrick Aaron; Nicolini, Valeria; Klein, Christian; Umana, Pablo; Seeber, Stefan; Perro, Mario; Leclair, Stephane

Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune response on drug exposure 第一阶段，TYRP1-TCB的首次人体研究 (RO7293583)，一种新型TYRP1-targeting CD3 T细胞接合器，用于转移性黑色素瘤: 主动药物监测以评估免疫反应对药物暴露的影响

FRONTIERS IN ONCOLOGY

IF3.3

2024-03-21

OAAI

Spreafico, Anna; Couselo, Eva Munoz; Irmisch, Anja; Bessa, Juliana; Au-Yeung, George; Bechter, Oliver; Svane, Inge Marie; Sanmamed, Miguel F.; Gambardella, Valentina; McKean, Meredith; Callahan, Margaret; Dummer, Reinhard; Klein, Christian; Umana, Pablo; Justies, Nicole; Heil, Florian; Fahrni, Linda; Opolka-Hoffmann, Eugenia; Waldhauer, Inja; Bleul, Conrad; Staack, Roland F.; Karanikas, Vaios; Fowler, Stephen

Combining venetoclax and azacytidine with T-cell bispecific antibodies for treatment of acute myeloid leukemia: a preclinical assessment

LEUKEMIA

IF13.4

2024-01-11

OAAI

Haenel, Gerulf; Schoenle, Anne; Neumann, Anne-Sophie; Nixdorf, Daniel; Philipp, Nora; Sponheimer, Monika; Leutbecher, Alexandra; Emhardt, Alica-Joana; Magno, Giulia; Buecklein, Veit; Eckmann, Jan; Dunshee, Diana; Kramar, Vesna; Korfi, Koorosh; Colombetti, Sara; Umana, Pablo; Klein, Christian; Subklewe, Marion

Selective targeting of IL2R0g combined with radiotherapy triggers CD8-and NK-mediated immunity, abrogating metastasis in HNSCC

CELL REPORTS MEDICINE

IF10.6

2023-08-01

OAAI

Gadwa, Jacob; Amann, Maria; Bickett, Thomas E.; Knitz, Michael W.; Darragh, Laurel B.; Piper, Miles; Van Court, Benjamin; Bukkapatnam, Sanjana; Pham, Tiffany T.; Wang, Xiao-Jing; Saviola, Anthony J.; Deak, Laura Codarri; Umana, Pablo; Klein, Christian; D'Alessandro, Angelo; Karam, Sana D.

Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2023-07-03

OAAI

Apollonio, Benedetta; Spada, Filomena; Petrov, Nedyalko; Cozzetto, Domenico; Papazoglou, Despoina; Jarvis, Peter; Kannambath, Shichina; Terranova-Barberio, Manuela; Amini, Rose-Marie; Enblad, Gunilla; Graham, Charlotte; Benjamin, Reuben; Phillips, Elisabeth; Ellis, Richard; Nuamah, Rosamond; Saqi, Mansoor; Calado, Dinis P.; Rosenquist, Richard; Sutton, Lesley A.; Salisbury, Jon; Zacharioudakis, Georgios; Vardi, Anna; Hagner, Patrick R.; Gandhi, Anita K.; Bacac, Marina; Claus, Christina; Umana, Pablo; Jarrett, Ruth F.; Klein, Christian; Deutsch, Alexander; Ramsay, Alan G.

研究方向