Mark J. Zylka - Publications, H-index & Citations

Mark J. Zylka

UNC

46H指数

173论文数

1.3W被引数

收录论文 54

发表时间

Perfluorooctanoic acid (PFOA) induces lipid accumulation; oxidative stress; and reduced neurogenesis in primary human neuronal progenitor cells 全氟辛酸（PFOA）诱导原代人类神经元祖细胞中脂质积累、氧化应激和神经发生减少

Frontiers in Toxicology

IF4.6

2026-05-15

OAAI

WP William P. Marinello; MJ Mark J. Zylka

Corrigendum to ‘The environmental neuroactive chemicals list of prioritized substances for human biomonitoring and neurotoxicity testing: A database and high-throughput toxicokinetics approach’ [Environ. Res. 2025 (266) 120537]勘误：‘用于人体生物监测和神经毒性测试的环境神经活性化学物质优先物质清单：一个数据库和高通量毒代动力学方法’ [Environ. Res. 2025 (266) 120537]

Environmental Research

IF7.7

2026-03-10

PREAI

Julia E. Rager; Lauren E. Koval; Elise Hickman; Caroline Ring; Taylor Teitelbaum; Todd Cohen; Giulia Fragola; Mark J. Zylka; Lawrence S. Engel; Kun Lu; Stephanie M. Engel

Multi-targeting zinc finger nuclease vector unsilences paternal UBE3A in a mouse model of Angelman syndrome 多靶向锌指核酸酶载体在天使综合征小鼠模型中激活了父源UBE3A。

Gene Therapy

IF4.5

2025-11-25

OAAI

Hannah O. Bazick; Lucas M. James; Bonnie Taylor-Blake; Justin M. Wolter; Mark J. Zylka

A luminescence-based biosensor to measure endogenous UBE3A activity 一种基于发光的生物传感器，用于测量内源性UBE3A活性

iScience

IF4.1

2025-10-03

OAAI

Lei Xing; Sophia U. Lamberti; Hannah C. Nourie; Trinity E. Rust; Wenxin Hu; Mark J. Zylka

AAV-dCas9 vector unsilences paternal Ube3a in neurons by impeding Ube3a-ATS transcription AAV-dCas9载体通过阻碍Ube3a-ATS转录来激活父源Ube3a在神经元中的表达

Communications Biology

IF5.1

2025-09-02

OAAI

Justin M. Wolter; Lucas M. James; Samantha L. Boeshore; Hanqian Mao; Eric S. McCoy; Daniel F. Ryan; Giulia Fragola; Bonnie Taylor-Blake; Jason L. Stein; Mark J. Zylka

Identifying environmental chemicals impacting neurodevelopment using a random mixture-based screening approach 使用基于随机混合物的筛选方法识别影响神经发育的环境化学物质

TOXICOLOGICAL SCIENCES

IF4.1

2025-06-01

PREAI

Hu, Wenxin; Xing, Lei; Park, Jieun; Taylor-Blake, Bonnie; Krantz, James L.; Hsiao, Yun-Chung; Liu, Chih-Wei; Lamberti, Sophia U.; Lu, Kun; Zylka, Mark J.

Enhanced facial grimacing when laparotomy involves cutaneous and visceral tissue injury 当剖腹手术涉及皮肤和内脏组织损伤时，面部 Grimacing 表情增强

PAIN Reports

IF3.1

2025-04-28

OAAI

Shao, Minghaoa; McCoy, Eric S.a, b; Zylka, Mark J.a, b

Exploring the Cytoplasmic Retention of CRISPR-Cas9 in Eukaryotic Cells: The Role of Nuclear Localization Signals and Ribosomal Interactions

CRISPR JOURNAL

IF4

2025-02-28

PREAI

Major, Rami M.; Mills, Christine A.; Xing, Lei; Krantz, James L.; Wolter, Justin M.; Zylka, Mark J.

AAV vector-derived elements integrate into Cas9-generated double-strand breaks and disrupt gene transcription

MOLECULAR THERAPY

IF12

2024-11-01

PREAI

Bazick, Hannah O.; Mao, Hanqian; Niehaus, Jesse K.; Wolter, Justin M.; Zylka, Mark J.

Co-detection of azoxystrobin and thiabendazole fungicides in mold and mildew resistant wallboards and in children

HELIYON

IF3.6

2024-03-01

OAAI

Hu, Wenxin; Hsiao, Yun-Chung; Morrison-Welch, Nikolas; Lamberti, Sophia; Liu, Chih-Wei; Lin, Weili; Engel, Stephanie M.; Lu, Kun; Zylka, Mark J.

Development of PainFace software to simplify, standardize, and scale up mouse grimace analyses

PAIN

IF5.5

2024-02-13

PREAI

Mccoy, Eric S.; Park, Sang Kyoon; Patel, Rahul P.; Ryan, Dan F.; Mullen, Zachary J.; Nesbitt, Jacob J.; Lopez, Josh E.; Taylor-Blake, Bonnie; Vanden, Kelly A.; Krantz, James L.; Hu, Wenxin; Garris, Rosanna L.; Snyder, Magdalyn G.; Lima, Lucas V.; Sotocinal, Susana G.; Austin, Jean-Sebastien; Kashlan, Adam D.; Shah, Sanya; Trocinski, Abigail K.; Pudipeddi, Samhitha S.; Major, Rami M.; Bazick, Hannah O.; Klein, Morgan R.; Mogil, Jeffrey S.; Wu, Guorong; Zylka, Mark J.

Urine Excretion, Organ Distribution, and Placental Transfer of 6PPD and 6PPD-Quinone in Mice and Potential Developmental Toxicity through Nuclear Receptor Pathways 小鼠中6PPD和6PPD-醌的尿液排泄，器官分布和胎盘转移以及通过核受体途径的潜在发育毒性

ENVIRONMENTAL SCIENCE & TECHNOLOGY

IF11.3

2023-08-29

PREAI

Zhao, Haoqi Nina; Thomas, Sydney P.; Zylka, Mark J.; Dorrestein, Pieter C.; Hu, Wenxin

Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice

CELL REPORTS

IF6.9

2023-07-01

OAAI

Xing, Lei; Simon, Jeremy M.; Ptacek, Travis S.; Yi, Jason J.; Loo, Lipin; Mao, Hanqian; Wolter, Justin M.; McCoy, Eric S.; Paranjape, Smita R.; Taylor-Blake, Bonnie; Zylka, Mark J.

Cellular Genome-wide Association Study Identifies Common Genetic Variation Influencing Lithium-Induced Neural Progenitor Proliferation

BIOLOGICAL PSYCHIATRY

IF9

2023-01-01

OAAI

Wolter, Justin M.; Le, Brandon D.; Matoba, Nana; Lafferty, Michael J.; Aygun, Nil; Liang, Dan; Courtney, Kenan; Song, Juan; Piven, Joseph; Zylka, Mark J.; Stein, Jason L.

scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy (vol 10, 5829, 2019)

NATURE COMMUNICATIONS

IF15.7

2022-05-26

OAAI

Ocasio, Jennifer Karin; Babcock, Benjamin; Malawsky, Daniel; Weir, Seth J.; Loo, Lipin; Simon, Jeremy M.; Zylka, Mark J.; Hwang, Duhyeong; Dismuke, Taylor; Sokolsky, Marina; Rosen, Elias P.; Vibhakar, Rajeev; Zhang, Jiao; Saulnier, Olivier; Vladoiu, Maria; El-Hamamy, Ibrahim; Stein, Lincoln D.; Taylor, Michael D.; Smith, Kyle S.; Northcott, Paul A.; Colaneri, Alejandro; Wilhelmsen, Kirk; Gershon, Timothy R.

Developmental pyrethroid exposure and age influence phenotypes in a Chd8 haploinsufficient autism mouse model

SCIENTIFIC REPORTS

IF3.9

2022-04-01

OAAI

Jimenez, Jessica A.; Simon, Jeremy M.; Hu, Wenxin; Moy, Sheryl S.; Harper, Kathryn M.; Liu, Chih-Wei; Lu, Kun; Zylka, Mark J.

Detection of Azoxystrobin Fungicide and Metabolite Azoxystrobin-Acid in Pregnant Women and Children, Estimation of Daily Intake, and Evaluation of Placental and Lactational Transfer in Mice

ENVIRONMENTAL HEALTH PERSPECTIVES

IF9.8

2022-02-01

OAAI

Hu, Wenxin; Liu, Chih-Wei; Jimenez, Jessica A.; McCoy, Eric S.; Hsiao, Yun-Chung; Lin, Weili; Engel, Stephanie M.; Lu, Kun; Zylka, Mark J.

A Nobel Prize for Sensational Research

NEW ENGLAND JOURNAL OF MEDICINE

IF78.5

2021-12-16

PREAI

Zylka, Mark J.

NuMorph: Tools for cortical cellular phenotyping in tissue-cleared whole-brain images

CELL REPORTS

IF6.9

2021-10-01

OAAI

Krupa, Oleh; Fragola, Giulia; Hadden-Ford, Ellie; Mory, Jessica T.; Liu, Tianyi; Humphrey, Zachary; Rees, Benjamin W.; Krishnamurthy, Ashok; Snider, William D.; Zylka, Mark J.; Wu, Guorong; Xing, Lei; Stein, Jason L.

Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life (vol 11, 74, 2020)

MOLECULAR AUTISM

IF5.5

2021-05-08

OAAI

Jimenez, Jessica A.; Ptacek, Travis S.; Tuttle, Alex H.; Schmid, Ralf S.; Moy, Sheryl S.; Simon, Jeremy M.; Zylka, Mark J.

研究方向