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G

Graham Ladds

University of Cambridge

28H指数
181论文数
2.8K被引数
收录论文 76
发表时间
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Uncoupling of the allosteric signalling network in the β1-adrenergic receptor by a negative allosteric modulator由负变构调节剂引起的β1-肾上腺素受体中别构信号网络的解偶联
errNature Communications
IF15.7
err2026-09-18
err0
errOAAI
errThomas H. Harman; Timothy Noel; Ali Nokhbehzaim; Abigail Pearce; Andrew J. Y. Jones; Anjana Saji; Matthew Harris; Venkat S. Vege; Aneesh Chandran; Pierre Leroy; Suleiman Al-Sabah; Graham Ladds; Daniel Nietlispach
err分享
err收藏
Molecular arrangement and modulation of extrasynaptic αβδ GABAA receptors突触外αβδ GABAA受体的分子排列与调节
errNature Communications
IF15.7
err2026-08-18
err0
errOAAI
errStephanie A. Nestorow; Wan-Na Chen; Daniel Bertrand; Ayla A. Wahid; Caroline E. Wyatt; Martin Mortensen; Thomas Clairfeuille; Michael Reutlinger; Gregoire Friz; Els Pardon; Jan Steyaert; Graham Ladds; Giuseppe Cecere; Trevor G. Smart; Maria-Clemencia Hernandez; Lisa Joedicke; Paul S. Miller
err分享
err收藏
Identification of glicentin as a low-potency glucose-dependent insulinotropic polypeptide receptor agonist将胰高血糖素样肽-1识别为低效能葡萄糖依赖性促胰岛素多肽受体激动剂
errPeptides
IF2.9
err2026-07-09
err0
errOAAI
errPaula-Peace James-Okoro; Joss Field; Graeme Davies; Abigail Pearce; Suleiman Al-Sabah; Koi Ni Lim; Graham Ladds; David Hornigold; Fiona Gribble; Frank Reimann
err分享
err收藏
Using a NanoBRET-Based Ligand-Binding Assay at the β2-Adrenoceptor for Undergraduate Pharmacology Education基于NanoBRET技术的β2-肾上腺素受体配体结合试验在本科药理学教育中的应用
errPharmacology Research & Perspectives
IF2.3
err2026-06-09
err0
errOAAI
errAbigail Pearce; Xianglin Huang; Theo Redfern-Nichols; Claudia M. Sisk; Dewi Safitri; Michael Collins; Milena A. Malcharek; Sergio Tomey García; Chiharu Nakamura; Andrzej Harris; Graham Ladds
err分享
err收藏
Evaluating 7-Aminopyrazolo[4; 3-d]pyrimidines as Human A1 and A3 Adenosine Receptor Antagonists评估7-氨基吡唑并[4;3-d]嘧啶作为人A1和A3腺苷受体拮抗剂
errACS Omega
IF4.3
err2026-05-14
err0
errOAAI
errKyriakos Georgiou; Maria Lamprakopoulou; Hannes Buthmann; Sabrina Böing; Athanasios Pousias; Aaron Dexter; Elizabeth Xin Yin Chew; Xianglin Huang; Eleni Ioanna Michalettou; Abigail Pearce; Yannis Dotsikas; Nicole Pouli; Panagiotis Marakos; Antonios Kolocouris; Graham Ladds; Nikolaos Lougiakis
err分享
err收藏
Enhancement of a nuclear factor of activated T cells (NFAT) reporter for the study of G protein-coupled receptors增强活化T细胞核因子（NFAT）报告基因以研究G蛋白偶联受体
errCommunications Biology
IF5.1
err2026-04-26
err0
errOAAI
errEdward Wills; Anjana Saji; Jonathan Sumner; Aman Khan; Claudia M. Sisk; Mona Shehata; Benjamin Taylor; Graham Ladds
err分享
err收藏
The potential for biased signalling in the P2Y receptor family of GPCRsP2Y受体家族GPCRs中偏倚性信号传导的潜力
errBRITISH JOURNAL OF PHARMACOLOGY
IF7.7
err2025-10-01
err0
errOAAI
errSisk, Claudia M.; Pitchford, Simon; Ladds, Graham
err分享
err收藏
Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain荧光GLP1R/GIPR双激动剂探针揭示胰腺和大脑中的细胞靶点
errNature Metabolism
IF20.8
err2025-08-19
err0
errOAAI
errAnne de Bray; Anna G. Roberts; Sarah Armour; Jason Tong; Christiane Huhn; Blaise Gatin-Fraudet; Kilian Roßmann; Ali H. Shilleh; Wanqing Jiang; Natalie S. Figueredo Burgos; James P. P. Trott; Katrina Viloria; Daniela Nasteska; Abigail Pearce; Satsuki Miyazaki; Jeremy W. Tomlinson; Dylan M. Owen; Daniel J. Nieves; Julia Ast; Malgorzata Cyranka; Alexey Epanchintsev; Carina Ämmälä; Frank Reimann; Tolga Soykan; Graham Ladds; Alice E. Adriaenssens; Stefan Trapp; Ben Jones; Johannes Broichhagen; David J. Hodson
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Receptor Activity-Modifying Protein 3 enhances GLP-1-mediated Insulin Secretion受体活性修饰蛋白3增强GLP-1介导的胰岛素分泌
errJournal of Biological Chemistry
IF3.9
err2025-08-18
err0
errOAAI
errAbigail Pearce; Poonam Kumari; Claudia M. Sisk; Matthew Harris; Ho Yan Yeung; Sabrina Winfield; Kathleen M. Caron; Graham Ladds
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Reversing the triad of anaesthesia in a cannot intubate, cannot oxygenate emergency. Comment on Br J Anaesth 2024; 133: 190–2在无法气管插管、无法氧合的紧急情况下逆转麻醉三联征。评论《Br J Anaesth》2024; 133: 190–2
errBritish Journal of Anaesthesia
IF9.2
err2025-06-06
err0
PREAI
errHuw Garland; Graham Ladds
err分享
err收藏
Loss-of-function Gαs rare disease variants exert mutation-specific effects on GPCR signaling失活功能型Gαs罕见病变异体对GPCR信号传导产生突变特异性的影响
errSCIENCE SIGNALING
IF6.6
err2025-05-20
err0
PREAI
errRedfern-Nichols, Theo; O'Brien, Shannon L.; Huang, Xianglin; Medel-Lacruz, Brian; Calebiro, Davide; Selent, Jana; Ladds, Graham; Marti-Solano, Maria
err分享
err收藏
New heterocyclic A1/A3 adenosine receptor ligands through molecular simplification strategies
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS
IF4.1
err2025-04-01
err0
errOAAI
errCrocetti, Letizia; Pearce, Abigail; Vege, Venkat S.; Xu, Qi; Xu, Jing; Buthmann, Hannes; Giovannoni, Maria Paola; Guerrini, Gabriella; Catarzi, Francesca; Selleri, Silvia; Huang, Xianglin; Chandran, Aneesh; Ladds, Graham; Cilibrizzi, Agostino
err分享
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Agonist efficacy at the β2AR is driven by the faster association rate of the Gs proteinβ2AR受体的激动剂效能由Gs蛋白更快的结合速率驱动。
errFRONTIERS IN PHARMACOLOGY
IF4.8
err2025-03-27
err0
errOAAI
errHarwood, Clare R.; Sykes, David A.; Redfern-Nichols, Theo; Underwood, Owen; Nicholson, Colin; Khoshgrudi, Armin N.; Koers, Eline J.; Ladds, Graham; Briddon, Stephen J.
err分享
err收藏
Quantitative approaches for studying G protein-coupled receptor signalling and pharmacology
errJOURNAL OF CELL SCIENCE
IF3.6
err2025-01-15
err1
errOAAI
errPearce, Abigail; Redfern-Nichols, Theo; Wills, Edward; Rosa, Matthew; Manulak, Iga; Sisk, Claudia; Huang, Xianglin; Atakpa-Adaji, Peace; Prole, David L.; Ladds, Graham
err分享
err收藏
Mechanistic Insights into the Adenosine A1 Receptor's Positive Allosteric Modulation for Non-Opioid Analgesics
errCELLS
IF5.2
err2024-12-21
err0
errOAAI
errWeizmann, Tal; Pearce, Abigail; Griffin, Peter; Schild, Achille; Flasshoff, Maren; Grossenbacher, Philipp; Lochner, Martin; Reynolds, Christopher A.; Ladds, Graham; Deganutti, Giuseppe
err分享
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ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+ uptake and oxidative metabolism
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-10-10
err2
errOAAI
errDematteis, Giulia; Tapella, Laura; Casali, Claudio; Talmon, Maria; Tonelli, Elisa; Reano, Simone; Ariotti, Adele; Pessolano, Emanuela; Malecka, Justyna; Chrostek, Gabriela; Kulkoviene, Gabriele; Umbrasas, Danielius; Distasi, Carla; Grilli, Mariagrazia; Ladds, Graham; Filigheddu, Nicoletta; Fresu, Luigia Grazia; Mikoshiba, Katsuhiko; Matute, Carlos; Ramos-Gonzalez, Paula; Jekabsone, Aiste; Cali, Tito; Brini, Marisa; Biggiogera, Marco; Cavaliere, Fabio; Miggiano, Riccardo; Genazzani, Armando A.; Lim, Dmitry
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GPR35 agonists inhibit TRPA1-mediated colonic nociception through suppression of substance P release
errPAIN
IF5.5
err2024-10-03
err0
PREAI
errGupta, Rohit A.; Higham, James P.; Pearce, Abigail; Urriola-Munoz, Paulina; Barker, Katie H.; Paine, Luke; Ghooraroo, Joshua; Raine, Tim; Hockley, James R. F.; Rahman, Taufiq; Smith, Ewan St John; Brown, Alastair J. H.; Ladds, Graham; Suzuki, Rie; Bulmer, David C.
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err收藏
The role of receptor activity-modifying proteins in obesity and diabetes mellitus
errJOURNAL OF MOLECULAR ENDOCRINOLOGY
IF3.8
err2024-09-18
err0
PREAI
errMalcharek, Milena A.; Pearce, Abigail; Brighton, Cheryl A.; Hornigold, David C.; Ladds, Graham
err分享
err收藏
Hit-to-Lead Optimization of Heterocyclic Carbonyloxycarboximidamides as Selective Antagonists at Human Adenosine A3 Receptor
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-07-29
err0
errOAAI
errHuang, Xianglin; Chorianopoulou, Anna; Kalkounou, Panagoula; Georgiou, Maria; Pousias, Athanasios; Davies, Amy; Pearce, Abigail; Harris, Matthew; Lambrinidis, George; Marakos, Panagiotis; Pouli, Nicole; Kolocouris, Antonios; Lougiakis, Nikolaos; Ladds, Graham
err分享
err收藏
Intracellular pathways of calcitonin gene-related peptide-induced relaxation of human coronary arteries: A key role for Gβγ subunit instead of cAMP
errBRITISH JOURNAL OF PHARMACOLOGY
IF7.7
err2024-04-07
err0
errOAAI
errde Vries, Tessa; Labruijere, Sieneke; Rivera-Mancilla, Eduardo; Garrelds, Ingrid M.; de Vries, Rene; Schutter, Dennis; van den Bogaerdt, Antoon; Poyner, David R.; Ladds, Graham; Danser, A. H. Jan; MaassenVanDenBrink, Antoinette
err分享
err收藏

研究方向

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合作学者
合作期刊
M
Michael P. Murphy
H 指数: 142 · 论文数: 780
K
Katsuhiko Mikoshiba
H 指数: 108 · 论文数: 744
P
Patrik Rorsman
H 指数: 104 · 论文数: 443
G
Gérard I. Evan
H 指数: 101 · 论文数: 479
B
Bernard Thorens
H 指数: 99 · 论文数: 379
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