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Indazole to 2-Cyanoindole Scaffold Progression for Mycobacterial Lipoamide Dehydrogenase Inhibitors Achieves Extended Target Residence Time and Improved Antibacterial Activity Sun, Shan; Ginn, John; Kochanczyk, Tomasz; Arango, Nancy; Jiang, Xiuju; Huggins, David J.; Bean, James; Michino, Mayako; Baxt, Leigh; Liverton, Nigel; Meinke, Peter T.; Bryk, Ruslana 分享 收藏
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Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055 Michino, Mayako; Khan, Tanweer A.; Miller, Michael W.; Fukase, Yoshiyuki; Vendome, Jeremie; Adura, Carolina; Glickman, J. Fraser; Liu, Yiman; Wan, Liling; Allis, C. David; Stamford, Andrew W.; Meinke, Peter T.; Renzetti, Louis M.; Kargman, Stacia; Liverton, Nigel J.; Huggins, David J. 分享 收藏
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation Sun, Shan; Fushimi, Makoto; Rossetti, Thomas; Kaur, Navpreet; Ferreira, Jacob; Miller, Michael; Quast, Jonathan; van den Heuvel, Joop; Steegborn, Clemens; Levin, Lonny R.; Buck, Jochen; Myers, Robert W.; Kargman, Stacia; Liverton, Nigel; Meinke, Peter T.; Huggins, David J. 分享 收藏
Using a Function-First Scout Fragment-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes Ramsey, Jared R.; Shelton, Patrick M. M.; Heiss, Tyler K.; Olinares, Paul Dominic B.; Vostal, Lauren E.; Soileau, Heather; Grasso, Michael; Casebeer, Sara W.; Adaniya, Stephanie; Miller, Michael; Sun, Shan; Huggins, David J.; Myers, Robert W.; Chait, Brian T.; Vinogradova, Ekaterina V.; Kapoor, Tarun M. 分享 收藏
Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors Michino, Mayako; Beautrait, Alexandre; Boyles, Nicholas A.; Nadupalli, Aparna; Dementiev, Alexey; Sun, Shan; Ginn, John; Baxt, Leigh; Suto, Robert; Bryk, Ruslana; Jerome, Steven V.; Huggins, David J.; Vendome, Jeremie 分享 收藏
Enhancing Hit Discovery in Virtual Screening through Absolute Protein-Ligand Binding Free-Energy Calculations Chen, Wei; Cui, Di; Jerome, Steven V.; Michino, Mayako; Lenselink, Eelke B.; Huggins, David J.; Beautrait, Alexandre; Vendome, Jeremie; Abel, Robert; Friesner, Richard A.; Wang, Lingle 分享 收藏
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation Sun, Shan; Fushimi, Makoto; Rossetti, Thomas; Kaur, Navpreet; Ferreira, Jacob; Miller, Michael; Quast, Jonathan; van den Heuvel, Joop; Steegborn, Clemens; Levin, Lonny R.; Buck, Jochen; Myers, Robert W.; Kargman, Stacia; Liverton, Nigel; Meinke, Peter T.; Huggins, David J. 分享 收藏
On-demand male contraception via acute inhibition of soluble adenylyl cyclase Balbach, Melanie; Rossetti, Thomas; Ferreira, Jacob; Ghanem, Lubna; Ritagliati, Carla; Myers, Robert W. W.; Huggins, David J. J.; Steegborn, Clemens; Miranda, Ileana C. C.; Meinke, Peter T. T.; Buck, Jochen; Levin, Lonny R. R. 分享 收藏
Design, Synthesis, and Pharmacological Evaluation of Second- Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates Miller, Michael; Rossetti, Thomas; Ferreira, Jacob; Ghanem, Lubna; Balbach, Melanie; Kaur, Navpreet; Levin, Lonny R.; Buck, Jochen; Kehr, Maria; Coquille, Sandrine; Heuvel, Joop van den; Steegborn, Clemens; Fushimi, Makoto; Finkin-Groner, Efrat; Myers, Robert W.; Kargman, Stacia; Liverton, Nigel J.; Huggins, David J.; Meinke, Peter T. 分享 收藏
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Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia Liu, Yiman; Li, Qinglan; Alikarami, Fatemeh; Barrett, Declan R.; Mahdavi, Leila; Li, Hangpeng; Tang, Sylvia; Khan, Tanweer A.; Michino, Mayako; Hill, Connor; Song, Lele; Yang, Lu; Li, Yuanyuan; Pokharel, Sheela Pangeni; Stamford, Andrew W.; Liverton, Nigel; Renzetti, Louis M.; Taylor, Simon; Watt, Gillian F.; Ladduwahetty, Tammy; Kargman, Stacia; Meinke, Peter T.; Foley, Michael A.; Shi, Junwei; Li, Haitao; Carroll, Martin; Chen, Chun-Wei; Gardini, Alessandro; Maillard, Ivan; Huggins, David J.; Bernt, Kathrin M.; Wan, Liling 分享 收藏
Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs 开发改进的Lats激酶抑制剂以促进哺乳动物器官的再生 Kastan, Nathaniel R.; Oak, Sanyukta; Liang, Rui; Baxt, Leigh; Myers, Robert W.; Ginn, John; Liverton, Nigel; Huggins, David J.; Pichardo, John; Paul, Matthew; Carroll, Thomas S.; Nagiel, Aaron; Gnedeva, Ksenia; Hudspeth, A. J. 分享 收藏
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A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors Liang, Rui; Tomita, Daisuke; Sasaki, Yusuke; Ginn, John; Michino, Mayako; Huggins, David J.; Baxt, Leigh; Kargman, Stacia; Shahid, Maaz; Aso, Kazuyoshi; Duggan, Mark; Stamford, Andrew W.; DeStanchina, Elisa; Liverton, Nigel; Meinke, Peter T.; Foley, Michael A.; Phillips, Richard E. 分享 收藏
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10) Fushimi, Makoto; Buck, Hannes; Balbach, Melanie; Gorovyy, Anna; Ferreira, Jacob; Rossetti, Thomas; Kaur, Navpreet; Levin, Lonny R.; Buck, Jochen; Quast, Jonathan; van den Heuvel, Joop; Steegborn, Clemens; Finkin-Groner, Efrat; Kargman, Stacia; Michino, Mayako; Foley, Michael A.; Miller, Michael; Liverton, Nigel J.; Huggins, David J.; Meinke, Peter T. 分享 收藏
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