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M

Mark A. McCoy

merck & company usa

H指数:30

被引数:2,620

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A Dehydration-Diffusion Competition Framework Predicts Interfacial Film Risk in High-Concentration Biologics Fill-Finish

MOLECULAR PHARMACEUTICS

IF4.5

2025-11-010

PRE

Rapid Characterization of Structural and Behavioral Changes of Therapeutic Proteins by Relaxation and Diffusion 1H-SOFAST NMR Experiments

ANALYTICAL CHEMISTRY

IF6.7

2024-10-020

PRE

Biostructural, biochemical and biophysical studies of mutant IDH1

NATURE COMMUNICATIONS

IF15.7

2024-09-090

OAAI

High-Throughput Fluorometric Assay For Quantifying Polysorbate In Biopharmaceutical Products Using Micelle Activated Fluorescence Probe N-Phenyl-1-Naphthylamine

PHARMACEUTICAL RESEARCH

IF4.3

2024-07-021

PRE

Insulin purification-Innovation continuum via synthesis of fundamentals, technology, and modeling

BIOTECHNOLOGY AND BIOENGINEERING

IF3.6

2023-05-184

PRE

Investigating protein-excipient interactions of a multivalent VHH therapeutic protein using NMR spectroscopy

IF7.3

2022-09-272

OAAI

Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2022-09-012

OAAI

Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-03-178

PRE

Pissarnitski, Dmitri A.; Kekec, Ahmet; Yan, Lin; Zhu, Yuping; Feng, Danqing D.; Huo, Pei; Madsen-Duggan, Christina; Moyes, Christopher R.; Nargund, Ravi P.; Kelly, Terri; Zhang, Xiaoping; Carballo-Jane, Ester; Gorski, Judith; Zafian, Peter; Qatanani, Mo; Kaarsholm, Niels; Meng, Fanyu; Jia, Xiujuan; Lee, Keun-Joong; Wang, Weixun; Xu, Sherrie; Hohn, Michael J.; Iammarino, Michael J.; McCoy, Mark A.; Okoh, Grace A.; Liang, Yingkai; Hollingsworth, Scott A.; Erion, Mark D.; Kelley, David E.; Garbaccio, Robert M.; Zhang, Amy; Mu, James; Lin, Songnian

Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-10-2919

PREAI

Reutershan, Michael H.; Machacek, Michelle R.; Altman, Michael D.; Bogen, Stephane; Cai, Mingmei; Cammarano, Carolyn; Chen, Dapeng; Christopher, Matthew; Cryan, John; Daublain, Pierre; Fradera, Xavier; Geda, Prasanthi; Goldenblatt, Peter; Hill, Armetta D.; Kemper, Raymond A.; Kutilek, Victoria; Li, Chaomin; Martinez, Michelle; McCoy, Mark; Nair, Latha; Pan, Weidong; Thompson, Christopher F.; Scapin, Giovanna; Shizuka, Manami; Spatz, Marianne L.; Steinhuebel, Dietrich; Sun, Binyuan; Voss, Matthew E.; Wang, Xiao; Yang, Liping; Yeh, Tammie C.; Dussault, Isabelle; Marshall, C. Gary; Trotter, B. Wesley

Probing IgG1 FC-Multimodal Nanoparticle Interactions: A Combined Nuclear Magnetic Resonance and Molecular Dynamics Simulations Approach

IF3.9

2021-10-1112

PRE

Quantification of natural abundance NMR data differentiates the solution behavior of monoclonal antibodies and their fragments

IF7.3

2021-10-060

OAAI

Crystal Structure and Characterization of Human Heavy-Chain Only Antibodies Reveals a Novel, Stable Dimeric Structure Similar to Monoclonal Antibodies

IF2.7

2020-11-224

OAAI

Identification of preferred multimodal ligand-binding regions on IgG1 FC using nuclear magnetic resonance and molecular dynamics simulations

BIOTECHNOLOGY AND BIOENGINEERING

IF3.6

2020-11-0617

PREAI

Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab

MOLECULAR CANCER THERAPEUTICS

IF5.5

2020-06-0216

OAAI

Profiling Insulin Oligomeric States by 1H NMR Spectroscopy for Formulation Development of Ultra-Rapid-Acting Insulin

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2020-01-018

OAAI

Nuclear Magnetic Resonance at the Interface: Identifying Preferred Binding Regions in Multimodal Cation Exchange Chromatography using Functionalized Nanoparticles

BIOPHYSICAL JOURNAL

IF3.1

2019-02-010

OAAI

Discovery of Selective RNA-Binding Small Molecules by Affinity Selection Mass Spectrometry

ACS CHEMICAL BIOLOGY

IF3.8

2018-02-0788

OAAI

Are Health Plan Design and Prior Use of Long-Acting Reversible Contraception Associated with Pregnancy Intention?

JOURNAL OF WOMENS HEALTH

IF1.9

2017-05-014

PREAI

Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets

IF4.9

2016-05-0438

OAAI

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2015-11-23207

PREAI