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K

Kathy Mulgrew

medimmune
H指数:18
被引数:2,377

个人简介

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工作经历

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荣誉奖项

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Improving dual targeting selectivity in T-cell engagers via synapse-gated and affinity-tuned trispecific antibody design

通过突触门控和亲和力调谐的三特异性抗体设计改善T细胞接合剂的双靶向选择性

MABS
IF7.3
2025-12-310
PRE
Zhao, Peng; Schardt, John; Chiang, Chi-, I; Shah, Pooja; Eun, Gee Sung; Martinek, Jan; Cyr, Matthew; Johnson, Yoshimi; Amofah, Bismark; Ye, Xiaoying; Edwards, Samuel; Chen, Xiaoru; Penney, Mark; Liu, Wenhai; Yang, Chunning; Rickert, Keith; Lee, Amber; Payne, Sterling; Zhang, Hanzhi; Kelly, Garrett; Wang, Chunlei; Gerber, Allison; Mulgrew, Kathy; Varma, Rajat; Boyd, Jonathan; Li, Xiuling; Bagert, John D.; Walseng, Even; Mazor, Yariv
IL-2-armored peptide-major histocompatibility class I bispecific antibodies redirect antiviral effector memory CD8+T cells to induce potent anti-cancer cytotoxic activity with limited cytokine release

IL-2-armored肽-主要组织相容性I类双特异性抗体重定向抗病毒效应记忆CD8 T细胞以诱导有效的抗癌细胞毒活性和有限的细胞因子释放

MABS
IF7.3
2024-08-280
OAAI
Schardt, John S.; Walseng, Even; Le, Kim; Yang, Chunning; Shah, Pooja; Fu, Ying; Alam, Kausar; Kelton, Cathryn R.; Gu, Yu; Huang, Fengying; Lin, Jia; Liu, Wenhai; Dippel, Andrew; Zhang, Hanzhi; Mulgrew, Kathy; Pryts, Stacy; Chennupati, Vijaykumar; Chen, Hung-Chang; Denham, Jessica; Chen, Xiaoru; Pradhan, Pallab; Wu, Yuling; Hardman, Colin; Zhao, Chihao; Kierny, Michael; Song, Yang; Dovedi, Simon J.; Cemerski, Saso; Mazor, Yariv
The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment

ATR抑制剂ceralasertib通过调节肿瘤微环境来增强癌症检查点免疫治疗

NATURE COMMUNICATIONS
IF15.7
2024-02-248
OAAI
Hardaker, Elizabeth L.; Sanseviero, Emilio; Karmokar, Ankur; Taylor, Devon; Milo, Marta; Michaloglou, Chrysis; Hughes, Adina; Mai, Mimi; King, Matthew; Solanki, Anisha; Magiera, Lukasz; Miragaia, Ricardo; Kar, Gozde; Standifer, Nathan; Surace, Michael; Gill, Shaan; Peter, Alison; Talbot, Sara; Tohumeken, Sehmus; Fryer, Henderson; Mostafa, Ali; Mulgrew, Kathy; Lam, Carolyn; Hoffmann, Scott; Sutton, Daniel; Carnevalli, Larissa; Calero-Nieto, Fernando J.; Jones, Gemma N.; Pierce, Andrew J.; Wilson, Zena; Campbell, David; Nyoni, Lynet; Martins, Carla P.; Baker, Tamara; de Almeida, Gilberto Serrano; Ramlaoui, Zainab; Bidar, Abdel; Phillips, Benjamin; Boland, Joseph; Iyer, Sonia; Barrett, J. Carl; Loembe, Arsene-Bienvenu; Fuchs, Serge Y.; Duvvuri, Umamaheswar; Lou, Pei-Jen; Nance, Melonie A.; Gomez Roca, Carlos Alberto; Cadogan, Elaine; Critichlow, Susan E.; Fawell, Steven; Cobbold, Mark; Dean, Emma; Valge-Archer, Viia; Lau, Alan; Gabrilovich, Dmitry I.; Barry, Simon T.
Distinct mechanisms govern populations of myeloid-derived suppressor cells in chronic viral infection and cancer
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2021-08-1653
OA
Tcyganov, Evgenii N.; Hanabuchi, Shino; Hashimoto, Ayumi; Campbell, David; Kar, Gozde; Slidel, Timothy W. F.; Cayatte, Corinne; Landry, Aimee; Pilataxi, Fernanda; Hayes, Susana; Dougherty, Brian; Hicks, Kristin C.; Mulgrew, Kathy; Tang, Chih-Hang Anthony; Hu, Chih-Chi Andrew; Guo, Wei; Grivennikov, Sergei; Ali, Mohammed-Alkhatim A.; Beltra, Jean-Christophe; Wherry, E. John; Nefedova, Yulia; Gabrilovich, Dmitry, I
Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non-Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
CANCER DISCOVERY
IF33.3
2021-07-0651
OA
Pore, Nabendu; Wu, Song; Standifer, Nathan; Jure-Kunkel, Maria; de los Reyes, Melissa; Shrestha, Yashaswi; Halpin, Rebecca; Rothstein, Raymond; Mulgrew, Kathy; Blackmore, Stephen; Martin, Philip; Meekin, John, III; Griffin, Matthew; Bisha, Ina; Proia, Theresa A.; Miragaia, Ricardo J.; Herbst, Ronald; Gupta, Ashok; Abdullah, Shaad E.; Raja, Rajiv; Frigault, Melanie M.; Barrett, J. Carl; Dennis, Phillip A.; Ascierto, Maria Libera; Oberst, Michael D.
Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1+ Activated T Cells

增强PD-1活化T细胞CTLA4阻断的单价双特异性PD-1/CTLA4抗体的设计和功效

CANCER DISCOVERY
IF33.3
2021-01-08123
PRE
Dovedi, Simon J.; Elder, Matthew J.; Yang, Chunning; Sitnikova, Suzanne, I; Irving, Lorraine; Hansen, Anna; Hair, James; Jones, Des C.; Hasani, Sumati; Wang, Bo; Im, Seock-Ah; Tran, Ben; Subramaniam, Deepa S.; Gainer, Shelby D.; Vashisht, Kapil; Lewis, Arthur; Jin, Xiaofang; Kentner, Stacy; Mulgrew, Kathy; Wang, Yaya; Overstreet, Michael G.; Dodgson, James; Wu, Yanli; Palazon, Asis; Morrow, Michelle; Rainey, Godfrey J.; Browne, Gareth J.; Neal, Frances; Murray, Thomas, V; Toloczko, Aleksandra D.; Dall'Acqua, William; Achour, Ikbel; Freeman, Daniel J.; Wilkinson, Robert W.; Mazor, Yariv
Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein
MOLECULAR CANCER THERAPEUTICS
IF5.5
2018-04-3036
OAAI
Oberst, Michael D.; Auge, Catherine; Morris, Chad; Kentner, Stacy; Mulgrew, Kathy; McGlinchey, Kelly; Hair, James; Hanabuchi, Shino; Du, Qun; Damschroder, Melissa; Feng, Hui; Eck, Steven; Buss, Nicholas; de Haan, Lolke; Pierce, Andrew J.; Park, Haesun; Sylwester, Andrew; Axthelm, Michael K.; Picker, Louis; Morris, Nicholas P.; Weinberg, Andrew; Hammond, Scott A.
Antibody-drug conjugates bearing pyrrolobenzodiazepine or tubulysin payloads alter the tumor immune microenvironment and synergize with multiple immunotherapies
CANCER RESEARCH
IF16.6
2017-07-011
PRE
Rios-Doria, Jonathan; Harper, Jay; Rothstein, Raymond; Wetzel, Leslie; Chesebrough, Jon; Marrero, Allison; Chen, Cui; Strout, Patrick; Mulgrew, Kathy; McGlinchey, Kelly; Fleming, Ryan; Bezabeh, Binyam; Meekin, John; Stewart, David; Kennedy, Maureen; Martin, Philip; Buchanan, Andrew; Dimasi, Nazzareno; Michelotti, Emil; Hollingsworth, Robert
Antibody-Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies

带有吡咯并苯并二氮杂或微管溶素有效载荷的抗体-药物结合物具有免疫调节作用，并与多种免疫疗法协同作用

CANCER RESEARCH
IF16.6
2017-05-1484
OAAI
Rios-Doria, Jonathan; Harper, Jay; Rothstein, Raymond; Wetzel, Leslie; Chesebrough, Jon; Marrero, Allison; Chen, Cui; Strout, Patrick; Mulgrew, Kathy; McGlinchey, Kelly; Fleming, Ryan; Bezabeh, Binyam; Meekin, John; Stewart, David; Kennedy, Maureen; Martin, Philip; Buchanan, Andrew; Dimasi, Nazzareno; Michelotti, Emil; Hollingsworth, Robert
Targeting CD73 in the tumor microenvironment with MEDI9447
ONCOIMMUNOLOGY
IF6.3
2016-07-11247
OAAI
Hay, Carl M.; Sult, Erin; Huang, Qihui; Mulgrew, Kathy; Fuhrmann, Stacy R.; McGlinchey, Kelly A.; Hammond, Scott A.; Rothstein, Raymond; Rios-Doria, Jonathan; Poon, Edmund; Holoweckyj, Nick; Durham, Nicholas M.; Leow, Ching Ching; Diedrich, Gundo; Damschroder, Melissa; Herbst, Ronald; Hollingsworth, Robert E.; Sachsenmeier, Kris F.

研究方向

暂未获取到该数据
S
Scott A. Hammond
H 指数:41论文数:246被引数:6,276
M
Michael D. Oberst
H 指数:33论文数:200被引数:3,605
K
Kelly McGlinchey
H 指数:20论文数:84被引数:1,627
S
Stacy Fuhrmann
H 指数:5论文数:19被引数:489
M
Melissa Damschroder
H 指数:27论文数:91被引数:3,281
Y
Yariv Mazor
H 指数:18论文数:55被引数:1,854
R
Raymond Rothstein
H 指数:17论文数:110被引数:1,966
C
Chunning Yang
H 指数:13论文数:31被引数:860
N
Nicholas M. Durham
H 指数:19论文数:108被引数:4,441
R
Robert W. Wilkinson
H 指数:57论文数:624被引数:1.3万