未登录 A strategic discovery roadmap towards high-quality leads and drug development candidates for kinetoplastid diseases. Part 3: from lead towards a drug development candidate 针对动基体疾病的高质量先导化合物和药物开发候选物的战略发现路线图。第3部分：从先导化合物到药物开发候选物 Hendrickx, Sarah; Ilbeigi, Kayhan; Thore, Eli S. J.; Bertram, Michael G.; Calvo-Alvarez, Estefania; Cintesun, Sener; Olias-Molero, Ana Isabel; Corral, Maria Jesus; Mateo-Barrientos, Marta; Estaquier, Jerome; Pomel, Sebastien; Alunda, Jose Maria; Gul, Sheraz; Van Bocxlaer, Katrien; Frezard, Frederic; Tavares, Joana; Da Silva, Anabela Cordeiro; Costi, Maria Paola; Maes, Louis; Caljon, Guy 分享 收藏
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A strategic discovery roadmap towards high-quality leads and drug development candidates for kinetoplastid diseases. Part 2: from molecule to confirmed hit 针对动基体病的高质量先导化合物和药物开发候选物的战略发现路线图。第二部分：从分子到确认的命中化合物 Hendrickx, Sarah; Ilbeigi, Kayhan; Thore, Eli S. J.; Bertram, Michael G.; Calvo-Alvarez, Estefania; Cintesun, Sener; Olias-Molero, Ana Isabel; Corral, Maria Jesus; Mateo-Barrientos, Marta; Estaquier, Jerome; Pomel, Sebastien; Alunda, Jose Maria; Gul, Sheraz; Van Bocxlaer, Katrien; Frezard, Frederic; Tavares, Joana; Cordeiro Da Silva, Anabela; Costi, Maria Paola; Maes, Louis; Caljon, Guy 分享 收藏
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Immune Alterations and Viral Reservoir Atlas in SIV-Infected Chinese Rhesus Macaques Clain, Julien A.; Picard, Morgane; Rabezanahary, Henintsoa; Andre, Sonia; Boutrais, Steven; Matsetse, Ella Goma; Dewatines, Juliette; Dueymes, Quentin; Thiboutot, Elise; Racine, Gina; Soundaramourty, Calaiselvy; Mammano, Fabrizio; Corbeau, Pierre; Zghidi-Abouzid, Ouafa; Estaquier, Jerome 分享 收藏
Monocytic reactive oxygen species-induced T-cell apoptosis impairs cellular immune response to SARS-CoV-2 mRNA vaccine 单核细胞源性活性氧诱导的T细胞凋亡损害了对SARS-CoV-2 mRNA疫苗的细胞免疫应答 Gimenez, Sandrine; Hamrouni, Emna; Andre, Sonia; Picard, Morgane; Soundaramourty, Calayselvy; Lozano, Claire; Vincent, Thierry; Tran, Tu-Anh; Kundura, Lucy; Estaquier, Jerome; Corbeau, Pierre 分享 收藏
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T4 apoptosis in the acute phase of SARS-CoV-2 infection predicts long COVID Cezar, Renaud; Kundura, Lucy; Andre, Sonia; Lozano, Claire; Vincent, Thierry; Muller, Laurent; Lefrant, Jean-Yves; Roger, Claire; Claret, Pierre-Geraud; Duvnjak, Sandra; Loubet, Paul; Sotto, Albert; Tran, Tu-Ahn; Estaquier, Jerome; Corbeau, Pierre 分享 收藏
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Repetitive mRNA vaccination is required to improve the quality of broad-spectrum anti-SARS-CoV-2 antibodies in the absence of CXCL13 Da Silva, Marne Azarias; Nioche, Pierre; Soudaramourty, Calaiselvy; Bull-Maurer, Anne; Tiouajni, Mounira; Kong, Dechuan; Zghidi-Abouzid, Ouafa; Picard, Morgane; Mendes-Frias, Ana; Santa-Cruz, Andre; Carvalho, Alexandre; Capela, Carlos; Pedrosa, Jorge; Castro, Antonio Gil; Loubet, Paul; Sotto, Albert; Muller, Laurent; Lefrant, Jean-Yves; Roger, Claire; Claret, Pierre-Geraud; Duvnjak, Sandra; Tu-Anh Tran; Tokunaga, Kenzo; Silvestre, Ricardo; Corbeau, Pierre; Mammano, Fabrizio; Estaquier, Jerome 分享 收藏
Early ART reduces viral seeding and innate immunity in liver and lungs of SIV-infected macaques 早期ART减少了SIV感染的猕猴的肝脏和肺部的病毒播种和先天免疫 Clain, Julien A.; Rabezanahary, Henintsoa; Racine, Gina; Boutrais, Steven; Soundaramourty, Calaiselvy; Beauparlant, Charles Joly; Jenabian, Mohammad -Ali; Droit, Arnaud; Ancuta, Petronela; Zghidi-Abouzid, Ouafa; Estaquier, Jerome 分享 收藏
Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8+β7 integrin+ T cells and anti-SARS-CoV-2 IgA response Cruz, Andre Santa; Mendes-Frias, Ana; Azarias-da-Silva, Marne; Andre, Sonia; Oliveira, Ana Isabel; Pires, Olga; Mendes, Marta; Oliveira, Barbara; Braga, Marta; Lopes, Joana Rita; Domingues, Rui; Costa, Ricardo; Silva, Luis Neves; Matos, Ana Rita; Angela, Cristina; Costa, Patricio; Carvalho, Alexandre; Capela, Carlos; Pedrosa, Jorge; Castro, Antonio Gil; Estaquier, Jerome; Silvestre, Ricardo 分享 收藏
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Low perforin expression in CD8+T lymphocytes during the acute phase of severe SARS-CoV-2 infection predicts long COVID 严重SARS-CoV-2感染急性期CD8 T淋巴细胞穿孔素低表达预示长期COVID Kundura, Lucy; Cezar, Renaud; Andre, Sonia; Campos-Mora, Mauricio; Lozano, Claire; Vincent, Thierry; Muller, Laurent; Lefrant, Jean-Yves; Roger, Claire; Claret, Pierre-Geraud; Duvnjak, Sandra; Loubet, Paul; Sotto, Albert; Tu-Ahn Tran; Estaquier, Jerome; Corbeau, Pierre 分享 收藏
Genotypic and Phenotypic Diversity of the Replication-Competent HIV Reservoir in Treated Patients Nicolas, Alexandre; Migraine, Julie; Dutrieux, Jacques; Salmona, Maud; Tauzin, Alexandra; Hachiya, Atsuko; Estaquier, Jerome; Molina, Jean-Michel; Clavel, Francois; Hance, Allan J.; Mammano, Fabrizio 分享 收藏
Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patients Andre, Sonia; da Silva, Marne Azarias; Picard, Morgane; Alleaume-Buteau, Aurelie; Kundura, Lucy; Cezar, Renaud; Soudaramourty, Calaiselvy; Andre, Santa Cruz; Mendes-Frias, Ana; Carvalho, Alexandre; Capela, Carlos; Pedrosa, Jorge; Castro, Antonio Gil; Loubet, Paul; Sotto, Albert; Muller, Laurent; Lefrant, Jean-Yves; Roger, Claire; Claret, Pierre-Geraud; Duvnjak, Sandra; Tu-Anh Tran; Zghidi-Abouzid, Ouafa; Nioche, Pierre; Silvestre, Ricardo; Corbeau, Pierre; Mammano, Fabrizio; Estaquier, Jerome 分享 收藏
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