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M

Mégane Brusson

inserm umr1163
H指数:12
被引数:466

个人简介

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教育背景

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工作经历

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荣誉奖项

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Enhanced γ-globin reactivation and sickle cell correction through a repressor-to-activator motif switch in the HBG1/2 promoters

通过HBG1/2启动子中的抑制因子-激活因子基序转换增强γ-球蛋白再激活和镰状细胞纠正

Molecular Therapy Nucleic Acids
IF6.1
2026-06-060
OAAI
Anne Chalumeau; Panagiotis Antoniou; Maria Bou Dames; Pierre Martinucci; Elena Retana; Pragya Gupta; Mike Firth; Muralidhar Reddivari; Aathira Sarath Chandran; Jonathan S. Yen; Martin Peterka; Marcello Maresca; Mégane Brusson; Annarita Miccio
A prime editing strategy to rewrite the γ-globin promoters and reactivate fetal hemoglobin for sickle cell disease

一种用于重写γ-球蛋白启动子并重新激活胎儿血红蛋白以治疗镰状细胞病的碱基编辑策略

Blood
IF23.1
2025-08-280
OAAI
Anne Chalumeau; Maria Bou Dames; Letizia Fontana; Simone Amistadi; Panagiotis Antoniou; Priyanka Loganathan; Margaux Mombled; Guillaume Corre; Martin Peterka; Mario Amendola; Carine Giovannangeli; Marcello Maresca; Annarita Miccio; Mégane Brusson
Severe inflammation and lineage skewing are associated with poor engraftment of engineered hematopoietic stem cells in patients with sickle cell disease

严重炎症和谱系偏移与 sickle cell disease 患者中工程化造血干细胞的植入不良相关。

NATURE COMMUNICATIONS
IF15.7
2025-04-010
OA
Sobrino, Steicy; Joseph, Laure; Magrin, Elisa; Chalumeau, Anne; Hebert, Nicolas; Corsia, Alice; Denis, Adeline; Roudaut, Cecile; Aussel, Clotilde; Leblanc, Olivia; Brusson, Megane; Felix, Tristan; Diana, Jean-Sebastien; Petrichenko, Angelina; El Etri, Jana; Godard, Auria; Tibi, Eden; Manceau, Sandra; Treluyer, Jean Marc; Mavilio, Fulvio; Bushman, Frederic D.; Marcais, Ambroise; Castelle, Martin; Neven, Benedicte; Hermine, Olivier; Renolleau, Sylvain; Magnani, Alessandra; Asnafi, Vahid; El Nemer, Wassim; Bartolucci, Pablo; Six, Emmanuelle; Semeraro, Michaela; Miccio, Annarita
Novel lentiviral vectors for gene therapy of sickle cell disease combining gene addition and gene silencing strategies

结合基因添加和基因沉默策略的镰状细胞病基因治疗的新型慢病毒载体

MOLECULAR THERAPY NUCLEIC ACIDS
IF6.1
2023-06-015
OAAI
Brusson, Megane; Chalumeau, Anne; Martinucci, Pierre; Romano, Oriana; Felix, Tristan; Poletti, Valentina; Scaramuzza, Samantha; Ramadier, Sophie; Masson, Cecile; Ferrari, Giuliana; Mavilio, Fulvio; Cavazzana, Marina; Amendola, Mario; Miccio, Annarita
Base-editing-mediated dissection of a γ-globin cis-regulatory element for the therapeutic reactivation of fetal hemoglobin expression

Γ-珠蛋白顺式调节元件的碱基编辑介导的解剖，用于胎儿血红蛋白表达的治疗性再激活

NATURE COMMUNICATIONS
IF15.7
2022-11-0434
OAAI
Antoniou, Panagiotis; Hardouin, Giulia; Martinucci, Pierre; Frati, Giacomo; Felix, Tristan; Chalumeau, Anne; Fontana, Letizia; Martin, Jeanne; Masson, Cecile; Brusson, Megane; Maule, Giulia; Rosello, Marion; Giovannangeli, Carine; Abramowski, Vincent; De Villartay, Jean-Pierre; Concordet, Jean-Paul; Del Bene, Filippo; El Nemer, Wassim; Amendola, Mario; Cavazzana, Marina; Cereseto, Anna; Romano, Oriana; Miccio, Annarita
Combination of lentiviral and genome editing technologies for the treatment of sickle cell disease

慢病毒与基因组编辑技术结合治疗镰状细胞病

MOLECULAR THERAPY
IF12
2022-01-016
OA
Ramadier, Sophie; Chalumeau, Anne; Felix, Tristan; Othman, Nadia; Aknoun, Sherazade; Casini, Antonio; Maule, Giulia; Masson, Cecile; De Cian, Anne; Frati, Giacomo; Brusson, Megane; Concordet, Jean-Paul; Cavazzana, Marina; Cereseto, Anna; El Nemer, Wassim; Amendola, Mario; Wattellier, Benoit; Meneghini, Vasco; Miccio, Annarita

研究方向

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A
Annarita Miccio
H 指数:34论文数:126被引数:3,883
A
Anne Chalumeau
H 指数:11论文数:37被引数:544
W
Wassim El Nemer
H 指数:32论文数:131被引数:3,606
M
Mario Amendola
H 指数:33论文数:183被引数:8,808
T
Tristan Félix
H 指数:17论文数:34被引数:1,219
G
Giacomo Frati
H 指数:11论文数:47被引数:572
M
Marina Cavazzana
H 指数:97论文数:598被引数:4.1万
A
Anna Cereseto
H 指数:37论文数:107被引数:5,138
J
Jean‐Jacques Kiladjian
H 指数:71论文数:760被引数:2.9万
J
Jean‐Paul Concordet
H 指数:46论文数:189被引数:1.5万