Aarti Krishnan - Publications, H-index & Citations

Aarti Krishnan

Broad Institute of MIT and Harvard

16H指数

37论文数

1.2K被引数

收录论文 16

发表时间

Deep learning–enabled discovery of antibiotics effective against Neisseria gonorrhoeae 深度学习赋能的针对淋病奈瑟菌的抗生素发现

Science Translational Medicine

IF14.6

2026-06-17

PREAI

Melis N. Anahtar; Jacqueline A. Valeri; Seyed Majed Modaresi; Aarti Krishnan; Nina M. Donghia; Samantha G. Palace; Erica J. Zheng; Aakanksha Gulati; Alicia Jorgenson; Abidemi Junaid; Parijat Bandyopadhyay; Andreas Luttens; Krishna Suresh; Paige Edwards; Felix Wong; Yu Zhang; Danilo Ritz; Margaux Gaborieau; Edmund Loh; Massimiliano Gaetani; Marie-Stephanie Aschtgen; Amir Ata Saei; Yonatan H. Grad; Donald E. Ingber; James J. Collins

A generative deep learning approach to de novo antibiotic design 一种用于全新抗生素设计的生成式深度学习方法

Cell

IF42.5

2025-08-14

PREAI

Aarti Krishnan; Melis N. Anahtar; Jacqueline A. Valeri; Wengong Jin; Nina M. Donghia; Leif Sieben; Andreas Luttens; Yu Zhang; Seyed Majed Modaresi; Andrew Hennes; Jenna Fromer; Parijat Bandyopadhyay; Jonathan C. Chen; Danyal Rehman; Ronak Desai; Paige Edwards; Ryan S. Lach; Marie-Stéphanie Aschtgen; Margaux Gaborieau; Massimiliano Gaetani; Samantha G. Palace; Satotaka Omori; Lutete Khonde; Yurii S. Moroz; Bruce Blough; Chunyang Jin; Edmund Loh; Yonatan H. Grad; Amir Ata Saei; Connor W. Coley; Felix Wong; James J. Collins

An explainable deep learning platform for molecular discovery

NATURE PROTOCOLS

IF16

2024-12-09

PREAI

Wong, Felix; Omori, Satotaka; Li, Alicia; Krishnan, Aarti; Lach, Ryan S.; Rufo, Joseph; Wilson, Maxwell Z.; Collins, James J.

Deep generative design of RNA aptamers using structural predictions 使用结构预测的RNA适体的深度生成设计

NATURE COMPUTATIONAL SCIENCE

IF18.3

2024-11-06

PREAI

Wong, Felix; He, Dongchen; Krishnan, Aarti; Hong, Liang; Wang, Alexander Z.; Wang, Jiuming; Hu, Zhihang; Omori, Satotaka; Li, Alicia; Rao, Jiahua; Yu, Qinze; Jin, Wengong; Zhang, Tianqing; Ilia, Katherine; Chen, Jack X.; Zheng, Shuangjia; King, Irwin; Li, Yu; Collins, James J.

Discovery of antibiotics that selectively kill metabolically dormant bacteria

CELL CHEMICAL BIOLOGY

IF7.2

2024-04-01

PREAI

Zheng, Erica J.; Valeri, Jacqueline A.; Andrews, Ian W.; Krishnan, Aarti; Bandyopadhyay, Parijat; Anahtar, Melis N.; Herneisen, Alice; Schulte, Fabian; Linnehan, Brooke; Wong, Felix; Stokes, Jonathan M.; Renner, Lars D.; Lourido, Sebastian; Collins, James J.

Dissection of Besnoitia besnoiti intermediate host life cycle stages: From morphology to gene expression

PLOS PATHOGENS

IF4.9

2022-11-17

OAAI

Ramakrishnan, Chandra; Krishnan, Aarti; Francisco, Samuel; Schmid, Marc W.; Russo, Giancarlo; Leitao, Alexandre; Hemphill, Andrew; Soldati-Favre, Dominique; Hehl, Adrian B.

Benchmarking AlphaFold-enabled molecular docking predictions for antibiotic discovery

MOLECULAR SYSTEMS BIOLOGY

IF7.7

2022-09-06

106

OAAI

Wong, Felix; Krishnan, Aarti; Zheng, Erica J.; Stark, Hannes; Manson, Abigail L.; Earl, Ashlee M.; Jaakkola, Tommi; Collins, James J.

N-acetylation of secreted proteins in Apicomplexa is widespread and is independent of the ER acetyl-CoA transporter AT1

JOURNAL OF CELL SCIENCE

IF3.6

2022-08-05

OAAI

Nyonda, Mary Akinyi; Boyer, Jean-Baptiste; Belmudes, Lucid; Krishnan, Aarti; Pino, Paco; Coute, Yohann; Brochet, Mathieu; Meinnel, Thierry; Soldati-Favre, Dominique; Giglione, Carmela

Ceramide biosynthesis is critical for establishment of the intracellular niche of Toxoplasma gondii

CELL REPORTS

IF6.9

2022-08-01

OAAI

Nyonda, Mary Akinyi; Kloehn, Joachim; Sosnowski, Piotr; Krishnan, Aarti; Lentini, Gaelle; Maco, Bohumil; Marq, Jean-Baptiste; Hannich, J. Thomas; Hopfgartner, Gerard; Soldati-Favre, Dominique

Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii

NATURE COMMUNICATIONS

IF15.7

2022-01-17

OAAI

Lunghi, Matteo; Kloehn, Joachim; Krishnan, Aarti; Varesio, Emmanuel; Vadas, Oscar; Soldati-Favre, Dominique

Pantothenate and CoA biosynthesis in Apicomplexa and their promise as antiparasitic drug targets

PLOS PATHOGENS

IF4.9

2021-12-30

OAAI

de Vries, Laura E.; Lunghi, Matteo; Krishnan, Aarti; Kooij, Taco W. A.; Soldati-Favre, Dominique

Revisiting the Role of Toxoplasma gondii ERK7 in the Maintenance and Stability of the Apical Complex

MBIO

IF4.7

2021-10-26

OAAI

Pacheco, Nicolas Dos Santos; Tosetti, Nicolo; Krishnan, Aarti; Haase, Romuald; Maco, Bohumil; Suarez, Catherine; Ren, Bingjian; Soldati-Favre, Dominique

Extensive regulation of enzyme activity by phosphorylation in Escherichia coli

NATURE COMMUNICATIONS

IF15.7

2021-09-24

OAAI

Schastnaya, Evgeniya; Nakic, Zrinka Raguz; Gruber, Christoph H.; Doubleday, Peter Francis; Krishnan, Aarti; Johns, Nathan, I; Park, Jimin; Wang, Harris H.; Sauer, Uwe

Amino Acid Metabolism in Apicomplexan Parasites

METABOLITES

IF3.7

2021-01-20

OAAI

Krishnan, Aarti; Soldati-Favre, Dominique

Vitamin and cofactor acquisition in apicomplexans: Synthesis versus salvage (vol 295, pg 701, 2019)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2020-03-01

OAAI

Krishnan, Aarti; Kloehn, Joachim; Lunghi, Matteo; Soldati-Favre, Dominique