Christopher W. am Ende - Publications, H-index & Citations

Christopher W. am Ende

pfizer inc.

31H指数

89论文数

3.9K被引数

收录论文 44

发表时间

Sulfonic Acid Promoted N-Boc-; N-Cbz-; and N-PMB Cleavage in 1; 1; 1; 3; 3; 3-Hexafluoro-2-Propanol (HFIP) and Application to Acid Sensitive Substrates 磺酸促进的N-Boc-、N-Cbz-和N-PMB在1,1,1,3,3,3-六氟-2-丙醇(HFIP)中的断裂及其在酸敏感底物中的应用

The Journal of Organic Chemistry

IF3.6

2026-05-18

PREAI

Eddie X. Yang; Amanda Pecora; Ethan L. Fisher; Christopher W. am Ende; John M. Humphrey

Tunable Cell Surface Proximity Labeling via Photocatalytic and Enzymatic Activation of Fast Bioorthogonal Chemistry 通过光催化和酶促激活快速生物正交化学实现可调的细胞表面邻近标记

Journal of the American Chemical Society

IF15.6

2026-04-29

PREAI

Samuel L. Scinto; Colette A. Makara; Minnie S. Nguyen; Paramesh K. Ramaraj; Yixin Xie; Colin Thorpe; Graham M. West; Christopher W. am Ende; Yingrong Xu; Joseph M. Fox

Sulfur fluoride exchange with carbon pronucleophiles 硫氟交换与碳亲核试剂的反应

Chem. Sci.

IF7.4

2025-08-16

OAAI

Joseph R. Novicki †; Matthew D. Teeter †; Neil J. Baldwin; Christopher W. am Ende; Thomas R. Puleo †; Alistair D. Richardson †; Nicholas D. Ball

Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2024-09-30

PREAI

Blakemore, Caroline A.; Humphrey, John M.; Yang, Eddie; Kohrt, Jeffrey T.; Morse, Peter Daniel; Howard, Roger M.; Yayla, Hatice G.; Knauber, Thomas; Xie, Longfei; Makowski, Teresa; Raggon, Jeffrey W.; Watson, Rebecca B.; Ende, Christopher W. Am; Ryder, Tim; White, Ormacinda; Koos, Martin R. M.; Kumar, Rajesh; Shi, Feng; Li, Jie; Wang, Huan; Chen, Like; Wang, Julai

Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease 临床候选PF-06648671的发现: 一种有效的 γ-分泌酶调节剂，用于治疗阿尔茨海默氏病

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-06-07

PREAI

Pettersson, Martin; Johnson, Douglas S.; Humphrey, John M.; Am Ende, Christopher W.; Butler, Todd W.; Dorff, Peter H.; Efremov, Ivan V.; Evrard, Edelweiss; Green, Michael E.; Helal, Christopher J.; Kauffman, Gregory W.; Mullins, Patrick B.; Navaratnam, Thayalan; O'Donnell, Christopher J.; O'Sullivan, Theresa J.; Patel, Nandini C.; Stepan, Antonia F.; Stiff, Cory M.; Subramanyam, Chakrapani; Trapa, Patrick; Tran, Tuan P.; Vetelino, Beth Cooper; Yang, Eddie; Xie, Longfei; Pustilnik, Leslie R.; Steyn, Stefanus J.; Wood, Kathleen M.; Bales, Kelly R.; Hajos-Korcsok, Eva; Verhoest, Patrick R.

Mechanistic differences between linear vs. spirocyclic dialkyldiazirine probes for photoaffinity labeling

CHEMICAL SCIENCE

IF7.4

2024-01-01

OAAI

O'Brien, Jessica G. K.; Conway, Louis P.; Ramaraj, Paramesh K.; Jadhav, Appaso M.; Jin, Jun; Dutra, Jason K.; Evers, Parrish; Masoud, Shadi S.; Schupp, Manuel; Saridakis, Iakovos; Chen, Yong; Maulide, Nuno; Pezacki, John P.; Ende, Christopher W. Am; Parker, Christopher G.; Fox, Joseph M.

Thiomethyltetrazines Are Reversible Covalent Cysteine Warheads Whose Dynamic Behavior can be Switched Off via Bioorthogonal Chemistry Inside Live Cells

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2023-07-14

PREAI

Tallon, Amanda M. M.; Xu, Yingrong; West, Graham M. M.; am Ende, Christopher W. W.; Fox, Joseph M. M.

Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2023-04-28

OAAI

Mattheisen, Jordan M.; Limberakis, Chris; Ruggeri, Roger B.; Dowling, Matthew S.; Ende, Christopher W. am; Ceraudo, Emilie; Huber, Thomas; McClendon, Christopher L.; Sakmar, Thomas P.

Structural basis of the acyl-transfer mechanism of human GPAT1

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2022-12-15

PREAI

Johnson, Zachary Lee; Ammirati, Mark; Wasilko, David Jonathan; Chang, Jeanne S.; Noell, Stephen; Foley, Timothy L.; Yoon, Hyejin; Smith, Kathleen; Asano, Shoh; Hales, Katherine; Wan, Min; Yang, Qingyi; Piotrowski, Mary A.; Farley, Kathleen A.; Gilbert, Tamara; Aschenbrenner, Lisa M.; Fennell, Kimberly F.; Dutra, Jason K.; Xu, Mary; Guo, Chunyang; Varghese, Alison E.; Bellenger, Justin; Quinn, Alandra; Ende, Christopher Am W.; West, Graham M.; Griffor, Matthew C.; Bennett, Donald; Calabrese, Matthew; Steppan, Claire M.; Han, Seungil; Wu, Huixian

Catalytic Activation of Bioorthogonal Chemistry with Light (CABL) Enables Rapid, Spatiotemporally Controlled Labeling and No-Wash, Subcellular 3D-Patterning in Live Cells Using Long Wavelength Light

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2022-01-24

OAAI

Jemas, Andrew; Xie, Yixin; Pigga, Jessica E.; Caplan, Jeffrey L.; Ende, Christopher W. Am; Fox, Joseph M.

A proteome-wide atlas of lysine-reactive chemistry (Sept, 10.1038/s41557-021-00765-4, 2021)

NATURE CHEMISTRY

IF20.2

2021-09-29

OAAI

Abbasov, Mikail E.; Kavanagh, Madeline E.; Ichu, Taka-Aki; Lazear, Michael R.; Tao, Yongfeng; Crowley, Vincent M.; Am Ende, Christopher W.; Hacker, Stephan M.; Ho, Jordan; Dix, Melissa M.; Suciu, Radu; Hayward, Matthew M.; Kiessling, Laura L.; Cravatt, Benjamin F.

Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum

CELL CHEMICAL BIOLOGY

IF7.2

2021-02-01

OAAI

Esquejo, Ryan M.; Roqueta-Rivera, Manuel; Shao, Wei; Phelan, Peter E.; Seneviratne, Uthpala; Ende, Christopher W. am; Hershberger, Paul M.; Machamer, Carolyn E.; Espenshade, Peter J.; Osborne, Timothy F.

Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE

CELL CHEMICAL BIOLOGY

IF7.2

2021-02-01

PREAI

Seneviratne, Uthpala; Huang, Zhen; Ende, Christopher W. am; Butler, Todd W.; Cleary, Leah; Dresselhaus, Erica; Evrard, Edelweiss; Fisher, Ethan L.; Green, Michael E.; Helal, Christopher J.; Humphrey, John M.; Lanyon, Lorraine F.; Marconi, Michael; Mukherjee, Paramita; Sciabola, Simone; Steppan, Claire M.; Sylvain, Emily K.; Tuttle, Jamison B.; Verhoest, Patrick R.; Wager, Travis T.; Xie, Longfei; Ramaswamy, Gayathri; Johnson, Douglas S.; Pettersson, Martin

Probing the Mechanism of Photoaffinity Labeling by Dialkyldiazirines through Bioorthogonal Capture of Diazoalkanes

ORGANIC LETTERS

IF5

2020-12-01

OAAI

O'Brien, Jessica G. K.; Jemas, Andrew; Asare-Okai, Papa Nii; Ende, Christopher W. am; Fox, Joseph M.

Divergent Synthesis of Monosubstituted and Unsymmetrical 3,6-Disubstituted Tetrazines from Carboxylic Ester Precursors

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2020-08-07

OAAI

Xie, Yixin; Fang, Yinzhi; Huang, Zhen; Tallon, Amanda M.; Am Ende, Christopher W.; Fox, Joseph M.

SuFEx Activation with Ca(NTf2)2 : A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides

ORGANIC LETTERS

IF5

2020-05-27

OAAI

Mahapatra, Subham; Woroch, Cristian P.; Butler, Todd W.; Carneiro, Sabrina N.; Kwan, Sabrina C.; Khasnavis, Samuel R.; Gu, Junha; Dutra, Jason K.; Vetelino, Beth C.; Bellenger, Justin; Ende, Christopher W. am; Ball, Nicholas D.

Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery 三氟甲基芳烃的有机光氧化加氢脱氟，对药物发现具有翻译适用性

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2020-05-07

131

OAAI

Sap, Jeroen B., I; Straathof, Natan J. W.; Knauber, Thomas; Meyer, Claudio F.; Medebielle, Maurice; Buglioni, Laura; Genicot, Christophe; Trabanco, Andres A.; Noel, Timothy; am Ende, Christopher W.; Gouverneur, Veronique

Installation of Minimal Tetrazines through Silver-Mediated Liebeskind-Srogl Coupling with Arylboronic Acids

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2019-10-11

OAAI

Lambert, William D.; Fang, Yinzhi; Mahapatra, Subham; Huang, Zhen; Ende, Christopher W. Am; Fox, Joseph M.

Dual-Reactivity trans-Cyclooctenol Probes for Sulfenylation in Live Cells Enable Temporal Control via Bioorthogonal Quenching

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2019-06-27

OAAI

Scinto, Samuel L.; Ekanayake, Oshini; Seneviratne, Uthpala; Pigga, Jessica E.; Boyd, Samantha J.; Taylor, Michael T.; Liu, Jun; Ende, Christopher W. Am; Rozovsky, Sharon; Fox, Joseph M.

Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10-2474

ACS CHEMICAL BIOLOGY

IF3.8

2019-01-31

OAAI

Huang, Zhen; Ogasawara, Daisuke; Seneviratne, Uthpala, I; Cognetta, Armand B., III; Ende, Christopher W. Am; Nason, Deane M.; Lapham, Kimberly; Litchfield, John; Johnson, Douglas S.; Cravatt, Benjamin F.

研究方向