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M

Mark Paetzel

Simon Fraser University
H指数:35
被引数:4,569

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Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance

治疗性Nirmatrelvir耐药突变在主要蛋白酶（Mpro）低频下的功能与结构表征揭示了一种SARS-CoV-2获得耐药性的独特进化路径

JOURNAL OF INFECTIOUS DISEASES
IF4.5
2025-06-010
OAAI
Deschenes, Natalie M.; Perez-Vargas, Jimena; Zhong, Zoe; Thomas, Merrilee; Kenward, Calem; Mosimann, Wesley A.; Worrall, Liam J.; Waglechner, Nicholas; Li, Angel XinLiu; Maguire, Finlay; Aftanas, Patryk; Smith, Jason R.; Lim, Jared; Young, Robert N.; Cherkasov, Artem; Farooqi, Lubna; Moinuddin, Adnan; Siddiqi, Lina; Malik, Imaan; Lefebvre, Maxime; Paetzel, Mark; Strynadka, Natalie C. J.; Jean, Francois; McGeer, Allison; Kozak, Robert A.
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants
EMERGING MICROBES & INFECTIONS
IF7.5
2023-08-232
OAAI
Perez-Vargas, Jimena; Worrall, Liam J.; Olmstead, Andrea D.; Ton, Anh-Tien; Lee, Jaeyong; Villanueva, Ivan; Thompson, Connor A. H.; Dudek, Svenja; Ennis, Siobhan; Smith, Jason R.; Shapira, Tirosh; De Guzman, Joshua; Gang, Shutong; Ban, Fuqiang; Vuckovic, Marija; Bielecki, Michael; Kovacic, Suzana; Kenward, Calem; Hong, Christopher Yee; Gordon, Danielle G.; Levett, Paul N.; Krajden, Mel; Leduc, Richard; Boudreault, Pierre-Luc; Niikura, Masahiro; Paetzel, Mark; Young, Robert N.; Cherkasov, Artem; Strynadka, Natalie C. J.; Jean, Francois

研究方向

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N.C.J. Strynadka
H 指数:79论文数:466被引数:1.9万
J
Jaeyong Lee
H 指数:13论文数:26被引数:763
A
Artem Cherkasov
H 指数:56论文数:350被引数:1.5万
L
L.J. Worrall
H 指数:31论文数:137被引数:3,642
M
M. Vuckovic
H 指数:20论文数:49被引数:2,152
C
Calem Kenward
H 指数:8论文数:20被引数:333
A
Anh‐Tien Ton
H 指数:14论文数:19被引数:1,975
M
Mark O. Lively
H 指数:33论文数:121被引数:3,554
A
Andrew Karla
H 指数:4论文数:9被引数:552
M
Mel Krajden
H 指数:72论文数:538被引数:2.3万