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C

Calem Kenward

University of Toronto
H指数:8
被引数:329

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Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance

治疗性Nirmatrelvir耐药突变在主要蛋白酶（Mpro）低频下的功能与结构表征揭示了一种SARS-CoV-2获得耐药性的独特进化路径

JOURNAL OF INFECTIOUS DISEASES
IF4.5
2025-06-010
OAAI
Deschenes, Natalie M.; Perez-Vargas, Jimena; Zhong, Zoe; Thomas, Merrilee; Kenward, Calem; Mosimann, Wesley A.; Worrall, Liam J.; Waglechner, Nicholas; Li, Angel XinLiu; Maguire, Finlay; Aftanas, Patryk; Smith, Jason R.; Lim, Jared; Young, Robert N.; Cherkasov, Artem; Farooqi, Lubna; Moinuddin, Adnan; Siddiqi, Lina; Malik, Imaan; Lefebvre, Maxime; Paetzel, Mark; Strynadka, Natalie C. J.; Jean, Francois; McGeer, Allison; Kozak, Robert A.
Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2
JOURNAL OF IMMUNOLOGY
IF3.4
2023-09-151
OA
Yu, Hong; Worrall, Liam J.; Berger, Thorsten; Petric, Martin; Lin, Bryan H.; Vuckovic, Marija; Robb, Craig S.; Le, Quan; Kenward, Calem; Dai, Chuanbin; Wakeham, Andrew; Liu, Shaofeng; Snow, Bryan; Tobin, Chantal; Budylowski, Patrick; Guvenc, Furkan; You-Ten, Annick; Haight, Jillian; Silvester, Jennifer; Singh, Rashim Pal; Ahn, Sang Kyun; Sultana, Azmiri; Poon, Betty; Lam, Jessica; Christie-Holmes, Natasha; Ostrowski, Mario; Gray-Owen, Scott D.; Kubli, Shawn; Mak, Tak; Strynadka, Natalie C. J.; Brunham, Robert C.
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants
EMERGING MICROBES & INFECTIONS
IF7.5
2023-08-232
OAAI
Perez-Vargas, Jimena; Worrall, Liam J.; Olmstead, Andrea D.; Ton, Anh-Tien; Lee, Jaeyong; Villanueva, Ivan; Thompson, Connor A. H.; Dudek, Svenja; Ennis, Siobhan; Smith, Jason R.; Shapira, Tirosh; De Guzman, Joshua; Gang, Shutong; Ban, Fuqiang; Vuckovic, Marija; Bielecki, Michael; Kovacic, Suzana; Kenward, Calem; Hong, Christopher Yee; Gordon, Danielle G.; Levett, Paul N.; Krajden, Mel; Leduc, Richard; Boudreault, Pierre-Luc; Niikura, Masahiro; Paetzel, Mark; Young, Robert N.; Cherkasov, Artem; Strynadka, Natalie C. J.; Jean, Francois

研究方向

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N
N.C.J. Strynadka
H 指数:79论文数:466被引数:1.9万
L
L.J. Worrall
H 指数:31论文数:137被引数:3,623
M
M. Vuckovic
H 指数:20论文数:49被引数:2,145
M
Mark Paetzel
H 指数:35论文数:103被引数:4,563
A
Artem Cherkasov
H 指数:56论文数:350被引数:1.5万
K
Kyungsoo Shin
H 指数:12论文数:40被引数:631
J
Jimena Pérez‐Vargas
H 指数:16论文数:33被引数:896
J
Jan K. Rainey
H 指数:29论文数:141被引数:2,639
R
Robert N. Young
H 指数:44论文数:245被引数:9,125
D
David N. Langelaan
H 指数:16论文数:74被引数:803