Masanori Osawa - Publications, H-index & Citations

Masanori Osawa

keio university

28H指数

103论文数

2.9K被引数

收录论文 47

发表时间

Allosteric Targeting of the ACE2 Dimer Interface by a Medium-sized Compound Inhibits SARS-CoV-2 Entry 中等大小化合物通过别构靶向ACE2二聚体界面抑制SARS-CoV-2进入

Journal of Molecular Biology

IF4.5

2026-06-22

OAAI

Mariko Yokogawa; Shunki Kaneichi; Mahoro Horiuchi; Taiga Otake; Tomoki Yonezawa; Yugo Shimizu; Kazuyoshi Ikeda; Yuichiro Yamamoto; Shota Sakai; Yoshimi Shimizu; Kohji Noguchi; Masayoshi Fukasawa; Mitsuhiko Ikura; Masanori Osawa

14-3-3ζ interacts with DNA-binding domain of FOXO3a and competitively dissociates DNA by dual-motif tethering 14-3-3ζ与FOXO3a的DNA结合域相互作用，并通过双基序连接竞争性地解离DNA

Nature Communications

IF15.7

2026-02-16

OAAI

Shota Enomoto; Tomoya Kuwayama; Shoichi Nakatsuka; Mariko Yokogawa; Kosaku Kawatsu; Risa Nakamura; Tomomi Kimura; Mikio Tanabe; Toshiya Senda; Jun Saito; Hideyuki Saya; Masanori Osawa

KMN003 activates Nrf2 via disruption of the Keap1-Nrf2 interaction and p38-dependent transcriptional regulation KMN003通过破坏Keap1-Nrf2相互作用和p38依赖性的转录调控激活Nrf2。

Cellular Signalling

IF3.7

2025-10-25

OAAI

Keijiro Komeda; Kai Toyoshima; Daisuke Yasuda; Hanako Ishida; Koujin Kojima; Masanori Osawa; Tomoya Hirano; Tomoyuki Ohe; Kenji Tago; Megumi Funakoshi-Tago

Development of Keap1-Nrf2 Protein–Protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene-2-acetamide Scaffold, and its Anti-Inflammatory Effects 基于萘-2-乙酰胺骨架开发激活细胞内Nrf2的Keap1-Nrf2蛋白质-蛋白质相互作用抑制剂及其抗炎作用

ChemMedChem

IF3.4

2025-09-03

OAAI

Daisuke Yasuda; Kai Toyoshima; Koujin Kojima; Hanako Ishida; Kazuma Kaitoh; Riyo Imamura; Kayoko Kanamitsu; Hirotatsu Kojima; Megumi Funakoshi-Tago; Masanori Osawa; Tomoyuki Ohe; Tomoya Hirano

Ribonuclease inhibitor and angiogenin system regulates cell type-specific global translation

SCIENCE ADVANCES

IF12.5

2024-05-31

OAAI

Stillinovic, Martina; Sarangdhar, Mayuresh Anant; Andina, Nicola; Tardivel, Aubry; Greub, Frederic; Bombaci, Giuseppe; Ansermet, Camille; Zatti, Marco; Saha, Dipanjali; Xiong, Jieyu; Sagae, Takeru; Yokogawa, Mariko; Osawa, Masanori; Heller, Manfred; Keogh, Adrian; Keller, Irene; Angelillo-Scherrer, Anne; Allam, Ramanjaneyulu

AI-driven molecular generation of not-patented pharmaceutical compounds using world open patent data 使用世界开放专利数据的非专利药物化合物的AI驱动分子生成

JOURNAL OF CHEMINFORMATICS

IF5.7

2023-12-13

OAAI

Shimizu, Yugo; Ohta, Masateru; Ishida, Shoichi; Terayama, Kei; Osawa, Masanori; Honma, Teruki; Ikeda, Kazuyoshi

PoSSuM v.3: A Major Expansion of the PoSSuM Database for Finding Similar Binding Sites of Proteins

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2023-11-28

OAAI

Tsuchiya, Yuko; Yonezawa, Tomoki; Yamamori, Yu; Inoura, Hiroko; Osawa, Masanori; Ikeda, Kazuyoshi; Tomii, Kentaro

TDP-43 N-terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate

FEBS LETTERS

IF3

2023-05-26

PREAI

Miura, Motoki; Sakaue, Fumika; Matsuno, Hirokazu; Morita, Kento; Yoshida, Akiko; Hara, Rintaro Iwata; Nishimura, Ren; Nishida, Yurika; Yokogawa, Mariko; Osawa, Masanori; Yokota, Takanori

DLiP-PPI library: An integrated chemical database of small-to-medium-sized molecules targeting protein-protein interactions

FRONTIERS IN CHEMISTRY

IF4.2

2023-01-09

OAAI

Ikeda, Kazuyoshi; Maezawa, Yuta; Yonezawa, Tomoki; Shimizu, Yugo; Tashiro, Toshiyuki; Kanai, Satoru; Sugaya, Nobuyoshi; Masuda, Yoshiaki; Inoue, Naoko; Niimi, Tatsuya; Masuya, Keiichi; Mizuguchi, Kenji; Furuya, Toshio; Osawa, Masanori

Applying deep learning to iterative screening of medium-sized molecules for protein-protein interaction-targeted drug discovery

CHEMICAL COMMUNICATIONS

IF4.2

2023-01-01

OAAI

Shimizu, Yugo; Yonezawa, Tomoki; Bao, Yu; Sakamoto, Junichi; Yokogawa, Mariko; Furuya, Toshio; Osawa, Masanori; Ikeda, Kazuyoshi

Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2022-05-01

OAAI

Sagae, Takeru; Yokogawa, Mariko; Sawazaki, Ryoichi; Ishii, Yuichiro; Hosoda, Nao; Hoshino, Shin-ichi; Imai, Shunsuke; Shimada, Ichio; Osawa, Masanori

Comprehensive Approach of 19F Nuclear Magnetic Resonance, Enzymatic, and In Silico Methods for Site-Specific Hit Selection and Validation of Fragment Molecules that Inhibit Methionine γ-Lyase Activity

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-09-28

PREAI

Ikeda, Kazuyoshi; Kezuka, Yuichiro; Nonaka, Takamasa; Yonezawa, Tomoki; Osawa, Masanori; Katoh, Etsuko

Identification of novel inhibitors of Keap1/Nrf2 by a promising method combining protein-protein interaction-oriented library and machine learning

SCIENTIFIC REPORTS

IF3.9

2021-04-01

OAAI

Shimizu, Yugo; Yonezawa, Tomoki; Sakamoto, Junichi; Furuya, Toshio; Osawa, Masanori; Ikeda, Kazuyoshi

GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress

MOLECULAR PHARMACOLOGY

IF3

2020-12-01

OAAI

Kato, Yu; Kunimasa, Kazuhiro; Takahashi, Mizuki; Harada, Ayaka; Nagasawa, Ikuko; Osawa, Masanori; Sugimoto, Yoshikazu; Tomida, Akihiro

Conformational equilibrium shift underlies altered K+ channel gating as revealed by NMR

NATURE COMMUNICATIONS

IF15.7

2020-10-14

OAAI

Iwahashi, Yuta; Toyama, Yuki; Imai, Shunsuke; Itoh, Hiroaki; Osawa, Masanori; Inoue, Masayuki; Shimada, Ichio

Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel

NATURE COMMUNICATIONS

IF15.7

2019-05-01

OAAI

Kano, Hanaho; Toyama, Yuki; Imai, Shunsuke; Iwahashi, Yuta; Mase, Yoko; Yokogawa, Mariko; Osawa, Masanori; Shimada, Ichio

Functional roles of Mg binding sites in ion-dependent gating of a Mg2+ channel Mg2+, revealed by solution NMR

ELIFE

IF0

2018-04-03

OAAI

Maruyama, Tatsuro; Imai, Shunsuke; Kusakizako, Tsukasa; Hattori, Motoyuki; Ishitani, Ryuichiro; Nureki, Osamu; Ito, Koichi; Maturana, Andres D.; Shimada, Ichio; Osawa, Masanori

Peierls stresses estimated via the Peierls-Nabarro model using ab-initio γ-surface and their comparison with experiments 使用从头算 γ 表面通过peierls-nabarro模型估算的Peierls应力及其与实验的比较

ACTA MATERIALIA

IF9.3

2018-04-01

OAAI

Kamimura, Y.; Edagawa, K.; Iskandarov, A. M.; Osawa, M.; Umeno, Y.; Takeuchi, S.

Structural basis for the ethanol action on G-protein-activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy NMR光谱揭示了乙醇对g蛋白激活的内向整流钾通道1的作用的结构基础

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2018-03-26

OAAI

Toyama, Yuki; Kano, Hanaho; Mase, Yoko; Yokogawa, Mariko; Osawa, Masanori; Shimada, Ichio