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T

Thomas Bohnacker

university of basel
H指数:18
被引数:1,237

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4-(Difluoromethyl)-5-(4-((3R,5S)-3,5-dimethylmorpholino)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a Potent, Orally Available, and Brain-Penetrant mTOR Inhibitor for the Treatment of Neurological Disorders
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-11-0916
OAAI
Borsari, Chiara; Keles, Erhan; Rageot, Denise; Treyer, Andrea; Bohnacker, Thomas; Bissegger, Lukas; De Pascale, Martina; Melone, Anna; Sriramaratnam, Rohitha; Beaufils, Florent; Hamburger, Matthias; Hebeisen, Paul; Loscher, Wolfgang; Fabbro, Doriano; Hillmann, Petra; Wymann, Matthias P.
(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-06-0750
OAAI
Rageot, Denise; Bohnacker, Thomas; Keles, Erhan; McPhail, Jacob A.; Hoffmann, Reece M.; Melone, Anna; Borsari, Chiara; Sriramaratnam, Rohitha; Sele, Alexander M.; Beaufils, Florent; Hebeisen, Paul; Fabbro, Doriano; Hillmann, Petra; Burke, John E.; Wymann, Matthias P.
New molecular and therapeutic insights into canine diffuse large B-cell lymphoma elucidates the role of the dog as a model for human disease
HAEMATOLOGICA
IF7.9
2018-12-1350
OAAI
Aresu, Luca; Ferraresso, Serena; Marconato, Laura; Cascione, Luciano; Napoli, Sara; Gaudio, Eugenio; Kwee, Ivo; Tarantelli, Chiara; Testa, Andrea; Maniaci, Chiara; Ciulli, Alessio; Hillmann, Petra; Bohnacker, Thomas; Wymann, Matthias P.; Comazzi, Stefano; Milan, Massimo; Riondato, Fulvio; Dalla Rovere, Giulia; Giantin, Mery; Giannuzzi, Diana; Bertoni, Francesco
Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-y1})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-10-2567
OAAI
Rageot, Denise; Bohnacker, Thomas; Melone, Anna; Langlois, Jean-Baptiste; Borsari, Chiara; Hillmann, Petra; Sele, Alexander M.; Beaufils, Florent; Zvelebil, Marketa; Hebeisen, Paul; Loescher, Wolfgang; Burke, John; Fabbro, Doriano; Wymann, Matthias P.
5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-09-01119
OAAI
Beaufils, Florent; Cmiljanovic, Natasa; Cmiljanovic, Vladimir; Bohnacker, Thomas; Melone, Anna; Marone, Romina; Jackson, Eileen; Zhang, Xuxiao; Sele, Alexander; Borsari, Chiara; Mestan, Jurgen; Hebeisen, Paul; Hillmann, Petra; Giese, Bernd; Zvelebil, Marketa; Fabbro, Doriano; Williams, Roger L.; Rageot, Denise; Wymann, Matthias P.
Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

Buparlisib的作用机制的解卷积定义了用于治疗干预的特定PI3K和微管蛋白抑制剂

NATURE COMMUNICATIONS
IF15.7
2017-03-0992
OAAI
Bohnacker, Thomas; Prota, Andrea E.; Beaufils, Florent; Burke, John E.; Melone, Anna; Inglis, Alison J.; Rageot, Denise; Sele, Alexander M.; Cmiljanovic, Vladimir; Cmiljanovic, Natasa; Bargsten, Katja; Aher, Amol; Akhmanova, Anna; Fernando Diaz, J.; Fabbro, Doriano; Zvelebil, Marketa; Williams, Roger L.; Steinmetz, Michel O.; Wymann, Matthias P.
BKM120-mediated G2 arrest: Structural and functional segregation of off-target action and PI3K inhibition
CANCER RESEARCH
IF16.6
2015-08-013
PRE
Bohnacker, Thomas; Beaufils, Florent; Prota, Andrea E.; Burke, John E.; Melone, Anna; Inglis, Alison J.; Fusco, Ludovico; Cmiljanovic, Vladimir; Cmiljanovic, Natasa; Rageot, Denise; Bargsten, Katja; Saez-Calvo, Gonzalo; Pertz, Olivier; Aher, Amol B.; Akhmanova, Anna; Diaz, Fernando J.; Fabbro, Doriano; Zvelebil, Marketa; Williams, Roger L.; Steinmetz, Michel O.; Wymann, Matthias P.

研究方向

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M
Matthias P. Wymann
H 指数:67论文数:211被引数:1.8万
D
Doriano Fabbro
H 指数:89论文数:350被引数:2.9万
A
Anna Melone
H 指数:11论文数:30被引数:664
F
Florent Beaufils
H 指数:24论文数:104被引数:2,738
D
Denise Rageot
H 指数:16论文数:50被引数:934
P
Petra Hillmann
H 指数:16论文数:67被引数:1,834
P
Paul Hebeisen
H 指数:18论文数:100被引数:1,224
A
Alexander Sele
H 指数:9论文数:37被引数:676
C
Chiara Borsari
H 指数:21论文数:76被引数:1,151
V
Vladimir Cmiljanović
H 指数:9论文数:76被引数:1,169