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P

Petra Hillmann

university of basel
H指数:16
被引数:1,834

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4-(Difluoromethyl)-5-(4-((3R,5S)-3,5-dimethylmorpholino)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a Potent, Orally Available, and Brain-Penetrant mTOR Inhibitor for the Treatment of Neurological Disorders
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-11-0916
OAAI
Borsari, Chiara; Keles, Erhan; Rageot, Denise; Treyer, Andrea; Bohnacker, Thomas; Bissegger, Lukas; De Pascale, Martina; Melone, Anna; Sriramaratnam, Rohitha; Beaufils, Florent; Hamburger, Matthias; Hebeisen, Paul; Loscher, Wolfgang; Fabbro, Doriano; Hillmann, Petra; Wymann, Matthias P.
(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-06-0750
OAAI
Rageot, Denise; Bohnacker, Thomas; Keles, Erhan; McPhail, Jacob A.; Hoffmann, Reece M.; Melone, Anna; Borsari, Chiara; Sriramaratnam, Rohitha; Sele, Alexander M.; Beaufils, Florent; Hebeisen, Paul; Fabbro, Doriano; Hillmann, Petra; Burke, John E.; Wymann, Matthias P.
New molecular and therapeutic insights into canine diffuse large B-cell lymphoma elucidates the role of the dog as a model for human disease
HAEMATOLOGICA
IF7.9
2018-12-1350
OAAI
Aresu, Luca; Ferraresso, Serena; Marconato, Laura; Cascione, Luciano; Napoli, Sara; Gaudio, Eugenio; Kwee, Ivo; Tarantelli, Chiara; Testa, Andrea; Maniaci, Chiara; Ciulli, Alessio; Hillmann, Petra; Bohnacker, Thomas; Wymann, Matthias P.; Comazzi, Stefano; Milan, Massimo; Riondato, Fulvio; Dalla Rovere, Giulia; Giantin, Mery; Giannuzzi, Diana; Bertoni, Francesco
Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-y1})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-10-2567
OAAI
Rageot, Denise; Bohnacker, Thomas; Melone, Anna; Langlois, Jean-Baptiste; Borsari, Chiara; Hillmann, Petra; Sele, Alexander M.; Beaufils, Florent; Zvelebil, Marketa; Hebeisen, Paul; Loescher, Wolfgang; Burke, John; Fabbro, Doriano; Wymann, Matthias P.
PQR309 Is a Novel Dual PI3K/mTOR Inhibitor with Preclinical Antitumor Activity in Lymphomas as a Single Agent and in Combination Therapy
CLINICAL CANCER RESEARCH
IF10.2
2018-01-0294
OAAI
Tarantelli, Chiara; Gaudio, Eugenio; Arribas, Alberto J.; Kwee, Ivo; Hillmann, Petra; Rinaldi, Andrea; Cascione, Luciano; Spriano, Filippo; Bernasconi, Elena; Guidetti, Francesca; Carrassa, Laura; Pittau, Roberta Bordone; Beaufils, Florent; Ritschard, Reto; Rageot, Denise; Sele, Alexander; Dossena, Barbara; Rossi, Francesca Maria; Zucchetto, Antonella; Taborelli, Monica; Gattei, Valter; Rossi, Davide; Stathis, Anastasios; Stussi, Georg; Broggini, Massimo; Wymann, Matthias P.; Wicki, Andreas; Zucca, Emanuele; Cmiljanovic, Vladimir; Fabbro, Doriano; Bertoni, Francesco
5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-09-01119
OAAI
Beaufils, Florent; Cmiljanovic, Natasa; Cmiljanovic, Vladimir; Bohnacker, Thomas; Melone, Anna; Marone, Romina; Jackson, Eileen; Zhang, Xuxiao; Sele, Alexander; Borsari, Chiara; Mestan, Jurgen; Hebeisen, Paul; Hillmann, Petra; Giese, Bernd; Zvelebil, Marketa; Fabbro, Doriano; Williams, Roger L.; Rageot, Denise; Wymann, Matthias P.
The dual PI3K/MTOR inhibitor PQR309 is active in mature B cell lymphoma cell lines bearing resistance to the PI3K-delta inhibitor idelalisib and specific gene expression features
CANCER RESEARCH
IF16.6
2016-07-150
PRE
Chiara, Tarantelli; Gaudio, Eugenio; Kwee, Ivo; Arribas, Alberto; Rinaldi, Andrea; Bernasconi, Elena; Cascione, Luciano; Hillmann, Petra; Stathis, Anastasios; Carrassa, Laura; Broggini, Massimo; Stussi, Georg; Fabbro, Doriano; Zucca, Emanuele; Cmiljanovic, Vladimir; Bertoni, Francesco

研究方向

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D
Doriano Fabbro
H 指数:89论文数:350被引数:2.9万
M
Matthias P. Wymann
H 指数:67论文数:211被引数:1.8万
A
Anna Melone
H 指数:11论文数:30被引数:667
F
Florent Beaufils
H 指数:24论文数:104被引数:2,739
P
Paul Hebeisen
H 指数:18论文数:100被引数:1,224
T
Thomas Bohnacker
H 指数:18论文数:42被引数:1,238
D
Denise Rageot
H 指数:16论文数:50被引数:936
V
Vladimir Cmiljanović
H 指数:9论文数:76被引数:1,170
A
Alexander Sele
H 指数:9论文数:37被引数:677
F
Francesco Bertoni
H 指数:95论文数:1,199被引数:3.0万