未登录 Real-World Applications and Experiences of AI/ML Deployment for Drug Discovery AI/ML在药物发现中部署的实际应用与经验 Pitt, Will R.; Bentley, Jonathan; Boldron, Christophe; Colliandre, Lionel; Esposito, Carmen; Frush, Elizabeth H.; Kopec, Jola; Labouille, Stephanie; Meneyrol, Jerome; Pardoe, David A.; Palazzesi, Ferruccio; Pozzan, Alfonso; Remington, Jacob M.; Rex, Rene; Southey, Michelle; Vishwakarma, Sachin; Walker, Paul 分享 收藏
The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability Vlasveld, Matthijs; Callegaro, Giulia; Fisher, Ciaran; Eakins, Julie; Walker, Paul; Lok, Samantha; van Oost, Siddh; de Jong, Brechtje; Pellegrino-Coppola, Damiano; Burger, Gerhard; Wink, Steven; van de Water, Bob 分享 收藏
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In-depth mechanistic analysis including high-throughput RNA sequencing in the prediction of functional and structural cardiotoxicants using hiPSC cardiomyocytes Rosell-Hidalgo, Alicia; Bruhn, Christopher; Shardlow, Emma; Barton, Ryan; Ryder, Stephanie; Samatov, Timur; Hackmann, Alexandra; Aquino, Gerald Ryan; Dos Reis, Micael Fernandes; Galatenko, Vladimir; Fritsch, Ruediger; Dohrmann, Cord; Walker, Paul A. 分享 收藏
Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells Carta, Giada; van der Stel, Wanda; Scuric, Emma W. J.; Capinha, Liliana; Delp, Johannes; Bennekou, Susanne Hougaard; Forsby, Anna; Walker, Paul; Leist, Marcel; van de Water, Bob; Jennings, Paul 分享 收藏
Protectiveness of NAM-Based Hazard Assessment - Which Testing Scope is Required? Zobl, Walter; Bitsch, Annette; Blum, Jonathan; Boei, Jan J. W. A.; Capinha, Liliana; Carta, Giada; Castell, Jose, V; Davoli, Enrico; Drake, Christina; Fisher, Ciaran P.; Heldring, Muriel M.; Islam, Barira; Jennings, Paul; Leist, Marcel; Pellegrino-Coppola, Damiano; Schimming, Johannes P.; Snijders, Kirsten E.; Tolosa, Laia; Water, Bob van de; Vugt-Lussenburg, Barbara M. A. van; Walker, Paul; Wehr, Matthias M.; Wijaya, Lukas S.; Escher, Sylvia E. 分享 收藏
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Are Non-animal Systemic Safety Assessments Protective? A Toolbox and Workflow Middleton, Alistair M.; Reynolds, Joe; Cable, Sophie; Baltazar, Maria Teresa; Li, Hequn; Bevan, Samantha; Carmichael, Paul L.; Dent, Matthew Philip; Hatherell, Sarah; Houghton, Jade; Kukic, Predrag; Liddell, Mark; Malcomber, Sophie; Nicol, Beate; Park, Benjamin; Patel, Hiral; Scott, Sharon; Sparham, Chris; Walker, Paul; White, Andrew 分享 收藏
Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action Escher, Sylvia E.; Aguayo-Orozco, Alejandro; Benfenati, Emilio; Bitsch, Annette; Braunbeck, Thomas; Brotzmann, Katharina; Bois, Frederic; van der Burg, Bart; Castel, Jose; Exner, Thomas; Gadaleta, Domenico; Gardner, Iain; Goldmann, Daria; Hatley, Oliver; Golbamaki, Nazanin; Graepel, Rabea; Jennings, Paul; Limonciel, Alice; Long, Anthony; Maclennan, Richard; Mombelli, Enrico; Norinder, Ulf; Jain, Sankalp; Capinha, Liliana Santos; Taboureau, Olivier T.; Tolosa, Laia; Vrijenhoek, Nanette G.; Van Vugt-Lussenburg, Barbara M. A.; Walker, Paul; van de Water, Bob; Wehr, Matthias; White, Andrew; Zdrazil, Barbara; Fisher, Ciaran 分享 收藏
Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling Loser, Dominik; Grillberger, Karin; Hinojosa, Maria G.; Blum, Jonathan; Haufe, Yves; Danker, Timm; Johansson, Ylva; Moeller, Clemens; Nicke, Annette; Bennekou, Susanne H.; Gardner, Iain; Bauch, Caroline; Walker, Paul; Forsby, Anna; Ecker, Gerhard F.; Kraushaar, Udo; Leist, Marcel 分享 收藏
Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs (vol 93, pg 219, 2020) Simeon, Segolene; Brotzmann, Katharina; Fisher, Ciaran; Gardner, Iain; Silvester, Steve; Maclennan, Richard; Walker, Paul; Braunbeck, Thomas; Bois, Frederic Y. 分享 收藏
Comparing in vitro human liver models to in vivo human liver using RNA-Seq Gupta, Rajinder; Schrooders, Yannick; Hauser, Duncan; van Herwijnen, Marcel; Albrecht, Wiebke; ter Braak, Bas; Brecklinghaus, Tim; Castell, Jose V.; Elenschneider, Leroy; Escher, Sylvia; Guye, Patrick; Hengstler, Jan G.; Ghallab, Ahmed; Hansen, Tanja; Leist, Marcel; Maclennan, Richard; Moritz, Wolfgang; Tolosa, Laia; Tricot, Tine; Verfaillie, Catherine; Walker, Paul; van de Water, Bob; Kleinjans, Jos; Caiment, Florian 分享 收藏
Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals (vol 33, pg 513, 2020) van der Stel, Wanda; Carta, Giada; Eakins, Julie; Darici, Salihanur; Delp, Johannes; Forsby, Anna; Bennekou, Susanne Hougaard; Gardner, Iain; Leist, Marcel; Danen, Erik H. J.; Walker, Paul; van de Water, Bob; Jennings, Paul 分享 收藏
Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals van der Stel, Wanda; Carta, Giada; Eakins, Julie; Darici, Salihanur; Delp, Johannes; Forsby, Anna; Bennekou, Susanne Hougaard; Gardner, Iain; Leist, Marcel; Danen, Erik H. J.; Walker, Paul; van de Water, Bob; Jennings, Paul 分享 收藏
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Identifying and Characterizing Stress Pathways of Concern for Consumer Safety in Next-Generation Risk Assessment Hatherell, Sarah; Baltazar, Maria T.; Reynolds, Joe; Carmichael, Paul L.; Dent, Matthew; Li, Hequn; Ryder, Stephanie; White, Andrew; Walker, Paul; Middleton, Alistair M. 分享 收藏
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Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury Longo, Diane M.; Woodhead, Jeffrey L.; Walker, Paul; Heredi-Szabo, Krisztina; Mogyorosi, Karoly; Wolenski, Francis S.; Dragan, Yvonne P.; Mosedale, Merrie; Siler, Scott Q.; Watkins, Paul B.; Howell, Brett A. 分享 收藏
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Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms Pridgeon, Chris S.; Schlott, Constanze; Wong, Min Wei; Heringa, Minne B.; Heckel, Tobias; Leedale, Joe; Launay, Laurence; Gryshkova, Vitalina; Przyborski, Stefan; Bearon, Rachel N.; Wilkinson, Emma L.; Ansari, Tahera; Greenman, John; Hendriks, Delilah F. G.; Gibbs, Sue; Sidaway, James; Sison-Young, Rowena L.; Walker, Paul; Cross, Mike J.; Park, B. Kevin; Goldring, Chris E. P. 分享 收藏
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