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P

Peter A. Sidhom

University of Bradford
H指数:17
被引数:663

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Discovery of 1,4-Diaryl-1,3-dihydro-2H-imidazole-2-thione Anticonvulsants Integrating AMPA Receptor Antagonism, Nav1.2 Channel Blockade, Redox Modulation, and Favorable Pharmacokinetic Properties

发现兼具AMPA受体拮抗、Nav1.2通道阻断、氧化还原调节和良好药代动力学特性的1,4-二芳基-1,3-二氢-2H-咪唑-2-硫酮类抗惊厥药物

European Journal of Medicinal Chemistry
IF5.9
2026-09-110
PRE
Shahenda Mahmoud; Tarek El-Moselhy; Eman El-Bastawissy; Nesma M.E. Abo El Nasr; Marawan A. Elbaset; Mahmoud A.A. Ibrahim; Shahzeb Khan; Tarad Abalkhail; Oleg I. Barygin; Arseniy S. Zhigulin; Vitalina V. Furman; Tatiana V. Karelina; Sun Huang; Gerald W. Zamponi; Peter A. Sidhom
Design and optimization of nafimidone-inspired hybrid scaffolds targeting NaV1.2 for antiepileptic therapy with reduced cardiac liability

以纳非米酮为灵感设计并优化靶向NaV1.2的抗癫痫治疗用杂合骨架，以降低心脏毒性

Bioorganic Chemistry
IF4.7
2026-08-010
PRE
Mahmoud, Shahenda; El-Moselhy, Tarek F.; El-Bastawissy, Eman A.; Salama, Abeer; Ibrahim, Mahmoud A. A.; Khan, Shahzeb; Pentlavalli, Sreekanth; Abalkhail, Tarad; Salih, Mohammed A. M.; Huang, Sun; Zamponi, Gerald W.; Sidhom, Peter A.
Paeoniflorin Ameliorates Cecal Ligation and Puncture-Induced Acute Lung Injury in Mice by Modulating Oxidative Stress, Apoptosis, and Inflammation: Shedding Light on the Role of the JAK2/STAT3 Pathway

芍药苷通过调节氧化应激、凋亡和炎症，减轻盲肠结扎穿刺诱导的小鼠急性肺损伤：阐明JAK2/STAT3通路的作用

Pharmaceuticals
IF4.8
2026-04-270
OAAI
Nourhan Hisham Shady; Reham H. Mohyeldin; Nehad M. Reda Abdel Maqsoud; Peter A. Sidhom; Mahmoud A. A. Ibrahim; Ahmed M. Shawky; Mohamed Hisham; Gerhard Bringmann; Usama Ramadan Abdelmohsen; Dalia H. Abu-Baih
InhibitWin Duo: Rational Design and Structural Insights into Dual PARP/HDAC Inhibitors for Synergistic DNA Repair Disruption and Epigenetic Modulation

InhibitWin Duo：双PARP/HDAC抑制剂的理性设计与结构洞察，用于协同DNA修复干扰和表观遗传调控

European Journal of Medicinal Chemistry
IF5.9
2026-03-060
PRE
Eman.M. Elkafoury; Tarek El-Moselhy; Mervat Elhammasy; Eman El-Bastawissy; Kamyar Afarinkia; Mohammed.A.M Salih; Ashraf K. El-Damasy; Mahmoud A.A. Ibrahim; Ahmed Elshewy; Ahmed M. Shawky; Rabah N. Alsulami; Othman R. Alzahrani; Laila Alhadad; Peter A. Sidhom
Exploring the Natural Products Atlas (NPAtlas) Database for Hunting Prospective Irreversible Covalent DprE1 Inhibitors With Antitubercular Activity: An Integrated In-Silico Approach

探索天然产物图谱（NPAtlas）数据库以寻找具有抗结核活性的潜在不可逆共价DprE1抑制剂：一种集成计算机模拟方法

Journal of Tropical Medicine
IF2.5
2026-01-010
OAAI
Ibrahim, Mahmoud A. A.; Mahmoud, Doaa G. M.; Ebada, Sherif S.; Sidhom, Peter A.; Mekhemer, Gamal A. H.; Hegazy, Mohamed-Elamir F.; Han, Yanshuo; Abalkhail, Tarad
Insights into impact of polar protic and aprotic solvents on bioactive features of 3-(Dimethylaminomethyl)-5-nitroindole: A DFT study and molecular dynamics simulations

对极性质子溶剂和极性质子惰性溶剂对3-(二甲胺甲基)-5-硝基吲哚生物活性特征影响的见解：一项DFT研究及分子动力学模拟

PLOS ONE
IF2.6
2025-09-100
OAAI
Koyambo-Konzapa, Steve-Jonathan; Vamhindi, Berthelot S. D. Ramlina; Khudaykulov, Bekzod; Sidhom, Peter A.; Khan, Shahzeb; Abdelbacki, Ashraf M. M.; Abdelrahman, Alaa H. M.; Ibrahim, Mahmoud A. A.
Potential P-glycoprotein (P-gp) inhibitors from SuperDRUG2 database toward reversing multidrug resistance in cancer treatment: Database mining, molecular dynamics, and binding energy estimations

SuperDRUG2数据库中用于逆转癌症治疗中多药耐药的潜在P-糖蛋白（P-gp）抑制剂：数据库挖掘、分子动力学及结合能估算

JOURNAL OF MOLECULAR GRAPHICS & MODELLING
IF3
2025-02-010
PRE
Abdeljawaad, Khlood A. A.; Abdelrahman, Alaa H. M.; Sidhom, Peter A.; Tallima, Hatem; Shoeib, Tamer; Mekhemer, Gamal A. H.; Sayed, Shaban R. M.; El-Tayeb, Mohamed A.; Hegazy, Mohamed-Elamir F.; Ibrahim, Mahmoud A. A.

研究方向

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M
Mahmoud A. A. Ibrahim
H 指数:35论文数:354被引数:4,448
A
Ahmed M. Shawky
H 指数:32论文数:178被引数:3,279
A
Alaa H. M. Abdelrahman
H 指数:16论文数:42被引数:868
S
Shaban R. M. Sayed
H 指数:19论文数:70被引数:1,287
M
Mohamed‐Elamir F. Hegazy
H 指数:38论文数:231被引数:5,155
T
Tamer Shoeib
H 指数:31论文数:130被引数:3,137
L
Lamiaa A. Mohamed
H 指数:12论文数:25被引数:257
G
Gamal A. H. Mekhemer
H 指数:25论文数:89被引数:1,832
A
Al‐shimaa S. M. Rady
H 指数:9论文数:23被引数:201
M
Mahmoud E. S. Soliman
H 指数:38论文数:340被引数:6,512