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R

Richard Alexander

Deakin University
H指数:33
被引数:3,784

个人简介

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教育背景

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工作经历

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荣誉奖项

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Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-10-313
PRE
Tichenor, Mark S.; Wiener, John J. M.; Rao, Navin L.; Bacani, Genesis M.; Wei, Jianmei; Deckhut, Charlotte Pooley; Barbay, J. Kent; Kreutter, Kevin D.; Chang, Leon; Clancy, Kathleen W.; Murrey, Heather E.; Wang, Weixue; Ahn, Kay; Huber, Michael; Rex, Elizabeth; Coe, Kevin J.; Wu, Jiejun; Rui, Haopeng; Sepassi, Kia; Gaudiano, Marcello; Bekkers, Mariette; Cornelissen, Ivo; Packman, Kathryn; Seierstad, Mark; Xiouras, Christos; Bembenek, Scott D.; Alexander, Richard; Milligan, Cynthia; Balasubramanian, Sriram; Lebsack, Alec D.; Venable, Jennifer D.; Philippar, Ulrike; Edwards, James P.; Hirst, Gavin
JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-09-2311
PREAI
Rombouts, Frederik J. R.; Kusakabe, Ken-ichi; Alexander, Richard; Austin, Nigel; Borghys, Herman; De Cleyn, Michel; Dhuyvetter, Deborah; Gijsen, Harrie J. M.; Hrupka, Brian; Jacobs, Tom; Jerhaoui, Soufyan; Lammens, Lieve; Leclercq, Laurent; Tsubone, Koichi; Ueno, Tatsuhiko; Morimoto, Kenji; Einaru, Shunsuke; Sumiyoshi, Hirokazu; Van den Bergh, An; Vos, Ann; Surkyn, Michel; Teisman, Ard; Moechars, Diederik
Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation
JOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
2017-10-01107
OAAI
Scannevin, Robert H.; Alexander, Richard; Haarlander, Tara Mezzasalma; Burke, Sharon L.; Singer, Monica; Huo, Cuifen; Zhang, Yue-Mei; Maguire, Diane; Spurlino, John; Deckman, Ingrid; Carroll, Karen I.; Lewandowski, Frank; Devine, Eric; Dzordzorme, Keli; Tounge, Brett; Milligan, Cindy; Bayoumy, Shariff; Williams, Robyn; Schalk-Hihi, Celine; Leonard, Kristi; Jackson, Paul; Todd, Matthew; Kuo, Lawrence C.; Rhodes, Kenneth J.
1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2015-10-1067
OAAI
Rombouts, Frederik J. R.; Tresadern, Gary; Delgado, Oscar; Martinez-Lamenca, Carolina; Van Gool, Michiel; Garcia-Molina, Aranzazu; de Diego, Sergio A. Alonso; Oehlrich, Daniel; Prokopcova, Hana; Alonso, Jose Manuel; Austin, Nigel; Borghys, Herman; Van Brandt, Sven; Surkyn, Michel; De Cleyn, Michel; Vos, Ann; Alexander, Richard; Macdonald, Gregor; Moechars, Dieder; Gijsen, Harrie; Trabanco, Andres A.
Design and synthesis of a series highly potent and bioavailable FASN KR domain inhibitors for cancer
CANCER RESEARCH
IF16.6
2014-10-015
PRE
Lu, Tianbao; Alexander, Richard; Bignan, Gilles; Bischoff, James; Connolly, Peter; Cummings, Max; De Breucker, Sabine; Esser, Norbert; Fraiponts, Erwin; Gilissen, Ron; Grasberger, Bruce; Janssens, Boudewijn; Ludovici, Donald; Meerpoel, Lieven; Meyer, Christophe; Parker, Michael; Peeters, Danielle; Schubert, Carsten; Smans, Karine; Van Nuffel, Luc; Vermeulen, Peter
Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2007-10-03396
PREAI
Pinto, Donald J. P.; Orwat, Michael J.; Koch, Stephanie; Rossi, Karen A.; Alexander, Richard S.; Smallwood, Angela; Wong, Pancras C.; Rendina, Alan R.; Luettgen, Joseph M.; Knabb, Robert M.; He, Kan; Xin, Baomin; Wexler, Ruth R.; Lam, Patrick Y. S.

研究方向

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E
Egan H. Doeven
H 指数:34论文数:115被引数:3,657
L
Luke C. Henderson
H 指数:43论文数:305被引数:5,836
P
Paul S. Francis
H 指数:52论文数:262被引数:8,279
R
Rosanne M. Guijt
H 指数:45论文数:215被引数:7,272
D
David J. Hayne
H 指数:22论文数:102被引数:1,824
A
Ann Vos
H 指数:21论文数:51被引数:1,720
A
Andreas Hendlmeier
H 指数:9论文数:15被引数:456
F
Frederik Rombouts
H 指数:24论文数:80被引数:1,810
D
Daniel J. Eyckens
H 指数:22论文数:66被引数:1,353
L
Ludovic F. Dumée
H 指数:61论文数:298被引数:1.2万