Jackson, Jeffrey J.; Shibuya, Grant M.; Ravishankar, Buvana; Adusumilli, Lavanya; Bradford, Delia; Brockstedt, Dirk G.; Bucher, Cyril; Bui, Minna; Cho, Cynthia; Colas, Christoph; Cutler, Gene; Dukes, Adrian; Han, Xinping; Hu, Dennis X.; Jacobson, Scott; Kassner, Paul D.; Katibah, George E.; Ko, Michelle Yoo Min; Kolhatkar, Urvi; Leger, Paul R.; Ma, Anqi; Marshall, Lisa; Maung, Jack; Ng, Andrew A.; Okano, Akinori; Pookot, Deepa; Poon, Daniel; Ramana, Chandru; Reilly, Maureen K.; Robles, Omar; Schwarz, Jacob B.; Shakhmin, Anton A.; Shunatona, Hunter P.; Sreenivasan, Raashi; Tivitmahaisoon, Parcharee; Xu, Mengshu; Zaw, Thant; Wustrow, David J.; Zibinsky, Mikhail

Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity In Vitro and In Vivo

MOLECULAR CANCER THERAPEUTICS

IF5.5

2020-10-0223

OAAI

Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-04-1750

PREAI

C1-CBP-vancomycin: Impact of a Vancomycin C-Terminus Trimethylammonium Cation on Pharmacological Properties and Insights into Its Newly Introduced Mechanism of Action

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2019-10-3128

OAAI

Discovery of potent and selective inhibitors of USP7 with anti-tumor activity in vitro and in vivo

CANCER RESEARCH

IF16.6

2019-07-011

PRE

Discovery and optimization of potent and selective inhibitors of USP7 to enhance anti-tumor immunity and target tumor growth

CANCER RESEARCH

IF16.6

2018-07-010

PRE

Abraham, Betty; Adusumilli, Lavanya; Biannic, Berenger; Bradford, Delia; Brovarney, Martin; Chian, David; Cutler, Gene; Han, Xinping; Hu, Dennis; Jacobson, Scott; Johnson, Sherra; Kassner, Paul; Kaveri, Deepika; Ketcham, John; Kim, Andrea; Leger, Paul; Marshall, Lisa; Marubayashi, Sachie; Maung, Jack; McKinnell, Jenny; Meleza, Cesar; Ohol, Yamini; Okano, Akinori; Peiser, Leanne; Pookot, Deepa; Rana, Payal; Schwarz, Jacob; Shah, Nick; Shibuya, Grant; Sun, Michael; Suthram, Silpa; Talay, Oezcan; Wadsworth, Angela; Wustrow, David; Young, Kyle; Napper, Andrew

Peripheral modifications of [Ψ[CH2NH]Tpg4]vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2017-05-30161

OAAI

Total Syntheses and Initial Evaluation of [Ψ[C(=S)NH]Tpg4]vancomycin, [Ψ[C(=NH)NH]Tpg4]vancomycin, [Ψ[CH2NH]Tpg4]vancomycin, and Their (4-Chlorobiphenyl)methyl Derivatives: Synergistic Binding Pocket and Peripheral Modifications for the Glycopeptide Antibiotics

[Ψ[C(= S)NH]Tpg4] 万古霉素、 [Ψ[C(= NH)NH]Tpg4] 万古霉素、 [Ψ[CH2NH]Tpg4] 万古霉素及其 (4-氯联苯) 甲基衍生物的总合成和初步评价: 糖肽抗生素的协同结合口袋和外周修饰

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2015-03-0967

OAAI

Total Synthesis of [Ψ[C(=NH)NH]Tpg4]Vancomycin and its (4-Chlorobiphenyl)methyl Derivative: Impact of Peripheral Modifications on Vancomycin Analogues Redesigned for Dual D-Ala-D-Ala and D-Ala-D-Lac Binding