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J

Jacob B. Schwarz

rapt therapeutics
H指数:27
被引数:3,005

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荣誉奖项

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Discovery and Characterization of Zelnecirnon (RPT193); a Potent and Selective CCR4 Antagonist for Allergic Disorders
Journal of Medicinal Chemistry
IF6.8
2026-01-230
PRE
Mikhail Zibinsky; Delia Bradford; Dirk G. Brockstedt; Ross Corriden; Jeffrey Jackson; Scott Jacobson; Sherry Jiao; Paul D. Kassner; John M. Ketcham; Lisa Marshall; Akinori Okano; Omar Robles; Jacob Schwarz; Oezcan Talay; Parcharee Tivitmahaisoon; Dianna Lester-Zeiner; Heather Milestone; Damian Trujillo; Ashkaan Younai; David J. Wustrow
Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-05-150
PRE
Braun, Marie-Gabrielle; Ashkenazi, Avi; Beveridge, Ramsay E.; Castanedo, Georgette; Wallweber, Heidi Ackerly; Beresini, Maureen H.; Clark, Kevin R.; De Bruyn, Tom; Fu, Liqiang; Gibbons, Paul; Jiang, Fan; Kaufman, Susan; Kan, David; Kiefer, James R.; Leclerc, Jean-Philippe; Lemire, Alexandre; Ly, Cuong; Segal, Ehud; Sims, Jessica; Wang, Weiru; Wei, Wentao; Zhao, Liang; Schwarz, Jacob B.; Rudolph, Joachim
Lipid Tales: Optimizing Arylomycin Membrane Anchors
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2023-10-113
PRE
Koehler, Michael F. T.; Chen, Yi-Chen; Chen, Yongsheng; Chen, Yuan; Crawford, James J.; Durk, Matthew R.; Garland, Keira; Hanan, Emily J.; Higuchi, Robert I.; Hu, Huiyong; Ly, Cuong Q.; Paraselli, Prasuna G.; Roberts, Tucker C.; Schwarz, Jacob B.; Smith, Peter A.; Yu, Zhiyong; Heise, Christopher E.
Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-09-206
PRE
Jackson, Jeffrey J.; Shibuya, Grant M.; Ravishankar, Buvana; Adusumilli, Lavanya; Bradford, Delia; Brockstedt, Dirk G.; Bucher, Cyril; Bui, Minna; Cho, Cynthia; Colas, Christoph; Cutler, Gene; Dukes, Adrian; Han, Xinping; Hu, Dennis X.; Jacobson, Scott; Kassner, Paul D.; Katibah, George E.; Ko, Michelle Yoo Min; Kolhatkar, Urvi; Leger, Paul R.; Ma, Anqi; Marshall, Lisa; Maung, Jack; Ng, Andrew A.; Okano, Akinori; Pookot, Deepa; Poon, Daniel; Ramana, Chandru; Reilly, Maureen K.; Robles, Omar; Schwarz, Jacob B.; Shakhmin, Anton A.; Shunatona, Hunter P.; Sreenivasan, Raashi; Tivitmahaisoon, Parcharee; Xu, Mengshu; Zaw, Thant; Wustrow, David J.; Zibinsky, Mikhail
Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity In Vitro and In Vivo
MOLECULAR CANCER THERAPEUTICS
IF5.5
2020-10-0223
OAAI
Ohol, Yamini M.; Sun, Michael T.; Cutler, Gene; Leger, Paul R.; Hu, Dennis X.; Biannic, Berenger; Rana, Payal; Cho, Cynthia; Jacobson, Scott; Wong, Steve T.; Sanchez, Jerick; Shah, Niket; Pookot, Deepa; Abraham, Betty; Young, Kyle; Suthram, Silpa; Marshall, Lisa A.; Bradford, Delia; Kozon, Nathan; Han, Xinping; Okano, Akinori; Maung, Jack; Colas, Christophe; Schwarz, Jacob; Wustrow, David; Brockstedt, Dirk G.; Kassner, Paul D.
Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-04-1750
PREAI
Leger, Paul R.; Hu, Dennis X.; Biannic, Berenger; Bui, Minna; Han, Xinping; Karbarz, Emily; Maung, Jack; Okano, Akinori; Osipov, Maksim; Shibuya, Grant M.; Young, Kyle; Higgs, Christopher; Abraham, Betty; Bradford, Delia; Cho, Cynthia; Colas, Christophe; Jacobson, Scott; Ohol, Yamini M.; Pookot, Deepa; Rana, Payal; Sanchez, Jerick; Shah, Niket; Sun, Michael; Wong, Steve; Brockstedt, Dirk G.; Kassner, Paul D.; Schwarz, Jacob B.; Wustrow, David J.
GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models
CELL REPORTS
IF6.9
2020-01-0156
OAAI
Hanson, Jesse E.; Ma, Keran; Elstrott, Justin; Weber, Martin; Saillet, Sandrine; Khan, Abdullah S.; Simms, Jeffrey; Liu, Benjamin; Kim, Thomas A.; Yu, Gui-Qiu; Chen, Yelin; Wang, Tzu-Ming; Jiang, Zhiyu; Liederer, Bianca M.; Deshmukh, Gauri; Solanoy, Hilda; Chan, Connie; Sellers, Benjamin D.; Volgraf, Matthew; Schwarz, Jacob B.; Hackos, David H.; Weimer, Robby M.; Sheng, Morgan; Gill, T. Michael; Scearce-Levie, Kimberly; Palop, Jorge J.
Discovery of potent and selective inhibitors of USP7 with anti-tumor activity in vitro and in vivo
CANCER RESEARCH
IF16.6
2019-07-011
PRE
Ohol, Yamini M.; Sun, Michael; Leger, Paul; Hu, Dennis; Biannic, Berenger; Rana, Payal; Cho, Cynthia; Jacobson, Scott; Wong, Steve; Sanchez, Jerick; Han, Xinping; Young, Kyle; Okano, Akinori; Maung, Jack; Cutler, Gene; Shah, Nick; Adusumilli, Lavanya; Kaveri, Deepika; Talay, Oezcan; Pookot, Deepa; Abraham, Betty; Bradford, Delia; Kozon, Nathan; Colas, Christophe; Kim, Andrea; Schwarz, Jacob; Wustrow, David; Brockstedt, Dirk; Kassner, Paul
Discovery and optimization of potent and selective inhibitors of USP7 to enhance anti-tumor immunity and target tumor growth
CANCER RESEARCH
IF16.6
2018-07-010
PRE
Abraham, Betty; Adusumilli, Lavanya; Biannic, Berenger; Bradford, Delia; Brovarney, Martin; Chian, David; Cutler, Gene; Han, Xinping; Hu, Dennis; Jacobson, Scott; Johnson, Sherra; Kassner, Paul; Kaveri, Deepika; Ketcham, John; Kim, Andrea; Leger, Paul; Marshall, Lisa; Marubayashi, Sachie; Maung, Jack; McKinnell, Jenny; Meleza, Cesar; Ohol, Yamini; Okano, Akinori; Peiser, Leanne; Pookot, Deepa; Rana, Payal; Schwarz, Jacob; Shah, Nick; Shibuya, Grant; Sun, Michael; Suthram, Silpa; Talay, Oezcan; Wadsworth, Angela; Wustrow, David; Young, Kyle; Napper, Andrew
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2016-11-0836
OAAI
Villemure, Elisia; Volgraf, Matthew; Jiang, Yu; Wu, Guosheng; Ly, Cuong Q.; Yuen, Po-wai; Lu, Aijun; Luo, Xifeng; Liu, Mingcui; Zhang, Shun; Lupardus, Patrick J.; Wallweber, Heidi J. A.; Liederer, Bianca M.; Deshmukh, Gauri; Plise, Emile; Tay, Suzanne; Wang, Tzu-Ming; Hanson, Jesse E.; Hackos, David H.; Scearce-Levie, Kimberly; Schwarz, Jacob B.; Sellers, Benjamin D.
Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-06-07128
OAAI
Blake, James F.; Burkard, Michael; Chan, Jocelyn; Chen, Huifen; Chou, Kang-Jye; Diaz, Dolores; Dudley, Danette A.; Gaudino, John J.; Gould, Stephen E.; Grina, Jonas; Hunsaker, Thomas; Liu, Lichuan; Martinson, Matthew; Moreno, David; Mueller, Lars; Orr, Christine; Pacheco, Patricia; Qin, Ann; Rasor, Kevin; Ren, Li; Robarse, Kirk; Shahidi-Latham, Sheerin; Stults, Jeffrey; Sullivan, Francis; Wang, Weiru; Yin, Jianping; Zhou, Aihe; Belvin, Marcia; Merchant, Mark; Moffat, John; Schwarz, Jacob B.
Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-03-0888
PREAI
Volgraf, Matthew; Sellers, Benjamin D.; Jiang, Yu; Wu, Guosheng; Ly, Cuong Q.; Villemure, Elisia; Pastor, Richard M.; Yuen, Po-wai; Lu, Aijun; Luo, Xifeng; Liu, Mingcui; Zhang, Shun; Sun, Liang; Fu, Yuhong; Lupardus, Patrick J.; Wallweber, Heidi J. A.; Liederer, Bianca M.; Deshmukh, Gauri; Plise, Emile; Tay, Suzanne; Reynen, Paul; Herrington, James; Gustafson, Amy; Liu, Yichin; Dirksen, Akim; Dietz, Matthias G. A.; Liu, Yanzhou; Wang, Tzu-Ming; Hanson, Jesse E.; Hackos, David; Scearce-Levie, Kimberly; Schwarz, Jacob B.

研究方向

暂未获取到该数据
D
David J. Wustrow
H 指数:26论文数:138被引数:2,807
P
Paul D. Kassner
H 指数:27论文数:100被引数:3,431
S
Samuel J. Danishefsky
H 指数:111论文数:1,329被引数:5.2万
S
Scott Jacobson
H 指数:8论文数:54被引数:402
D
Dennis X. Hu
H 指数:19论文数:53被引数:1,310
A
Akinori Okano
H 指数:16论文数:73被引数:1,290
P
Peter W. Glunz
H 指数:17论文数:41被引数:1,607
S
Scott D. Kuduk
H 指数:40论文数:202被引数:5,140
D
Delia Bradford
H 指数:4论文数:28被引数:205
G
Gene Cutler
H 指数:16论文数:48被引数:1,479