Willem A. L. van Otterlo

University of Florida

37H指数

252论文数

4.7K被引数

收录论文 44

发表时间

Concise Access to Naphthalene Building Blocks for Naphthylisoquinoline Alkaloid Synthesis via Transition-Metal Catalysis

CHEMCATCHEM

IF3.9

2024-10-21

OAAI

Materis, Marios-Christoforos; van Otterlo, Willem A. L.; Berthold, Dino

Sphaeropsidin A C15-C16 Cross-Metathesis Analogues with Potent Anticancer Activity Sphaeropsidin一种具有有效抗癌活性的C15-C16交叉复分解类似物

CHEMMEDCHEM

IF3.4

2024-08-23

PREAI

Wagh, Sachin B.; Berthold, Dino; Majeed, Iram; Lewis, L. Kevin; Schilter, David; Mertens, Birgit; Evidente, Antonio; van Otterlo, Willem A. L.; Mathieu, Veronique; Kornienko, Alexander

New hemisynthetic derivatives of sphaeropsidin phytotoxins triggering severe endoplasmic reticulum swelling in cancer cells 新的球果素植物毒素的半合成衍生物触发癌细胞中严重的内质网肿胀

SCIENTIFIC REPORTS

IF3.9

2024-06-25

OAAI

Ingels, Aude; Scott, Robert; Hooper, Annie R.; van der Westhuyzen, Aletta E.; Wagh, Sachin B.; de Meester, Josephine; Maddau, Lucia; Marko, Doris; Aichinger, Georg; Berger, Walter; Vermeersch, Marjorie; Perez-Morga, David; Maslivetc, Vladimir A.; Evidente, Antonio; van Otterlo, Willem A. L.; Kornienko, Alexander; Mathieu, Veronique

Improved Rigidin-Inspired Antiproliferative Agents with Modifications on the 7-Deazahypoxanthine C7/C8 Ring Systems

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-06-12

OAAI

van der Westhuyzen, Aletta E.; Ashraf, Naghmana; Conradie, Daleen; Loots, Leigh; Kaschula, Catherine H.; Pelly, Stephen C.; Frolova, Liliya V.; Landfair, Taylor; Shuster, Charles B.; Betancourt, Tania; Kornienko, Alexander; van Otterlo, Willem A. L.

The role of silicon in drug discovery: a review

RSC MEDICINAL CHEMISTRY

IF3.6

2024-01-01

OAAI

Panayides, Jenny-Lee; Riley, Darren Lyall; Hasenmaile, Felix; van Otterlo, Willem A. L.

Atroposelective NiII-Catalyzed Cross-Coupling Reactions Enable a Deeper Understanding of Negishi Couplings: Isolation and Application of Solid Aryl Higher-Order Zincates

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2023-10-17

OAAI

Gross, Damian; van Otterlo, Willem A. L.; Trapp, Oliver; Berthold, Dino

Unprecedented Direct Asymmetric Total Syntheses of 5,8'-Naphthylisoquinoline Alkaloids from their Fully Substituted Precursors Employing a Novel Nickel/N,N-ligand-Catalyzed Atroposelective Cross-Coupling Reaction

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2023-09-29

OAAI

Berthold, Dino; van Otterlo, Willem

A novel 4′-brominated derivative of fisetin induces cell cycle arrest and apoptosis and inhibits EGFR/ERK1/2/STAT3 pathways in non-small-cell lung cancer without any adverse effects in mice

FASEB JOURNAL

IF4.2

2022-11-24

PREAI

Sabarwal, Akash; van Rooyen, Jaco C.; Caburet, Jeremy; Avgenikos, Moscos; Dheeraj, Arpit; Ali, Mansoor; Mishra, Deepali; de Meester, Josephine S. B.; Stander, Saskia; van Otterlo, Willem A. L.; Kaschula, Catherine H.; Singh, Rana P.

Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach 使用点击片段方法产生的Akt的共价变构抑制剂

CHEMMEDCHEM

IF3.4

2022-03-09

OAAI

Westhuizen, Leandi; Weisner, Joern; Taher, Abu; Landel, Ina; Quambusch, Lena; Lindemann, Marius; Uhlenbrock, Niklas; Mueller, Matthias P.; Green, Ivan R.; Pelly, Stephen C.; Rauh, Daniel; van Otterlo, Willem A. L.

Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-09-15

PREAI

Lategahn, Jonas; Hardick, Julia; Grabe, Tobias; Niggenaber, Janina; Jeyakumar, Kirujan; Keul, Marina; Tumbrink, Hannah L.; Becker, Christian; Hodson, Luke; Kirschner, Tonia; Kloevekorn, Philip; Ketzer, Julia; Baumann, Matthias; Terheyden, Susanne; Unger, Anke; Weisner, Joern; Mueller, Matthias P.; van Otterlo, Willem A. L.; Bauer, Sebastian; Rauh, Daniel

The Phylum Bryozoa: From Biology to Biomedical Potential

MARINE DRUGS

IF5.4

2020-04-09

OAAI

Ciavatta, Maria Letizia; Lefranc, Florence; Vieira, Leandro M.; Kiss, Robert; Carbone, Marianna; van Otterlo, Willem A. L.; Lopanik, Nicole B.; Waeschenbach, Andrea

α-costic acid, a plant sesquiterpenoid from Dittrichia viscosa, as modifier of Poly (lactic acid) properties: a novel exploitation of the autochthone biomass metabolite for a wholly biodegradable system

INDUSTRIAL CROPS AND PRODUCTS

IF6.2

2020-04-01

PREAI

Moeini, Arash; van Reenen, Albert; Van Otterlo, Willem; Cimmino, Alessio; Masi, Marco; Lavermicocca, Paola; Valerio, Francesca; Immirzi, Barbara; Santagata, Gabriella; Malinconico, Mario; Evidente, Antonio

Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multidrug-Resistance Proteins

CHEMMEDCHEM

IF3.4

2019-01-25

OAAI

Dasari, Ramesh; Blauz, Andrzej; Medellin, Derek C.; Kassim, Roaa M.; Viera, Carlos; Santarosa, Maximo; van der Westhuyzen, Alet E.; van Otterlo, Willem A. L.; Olivas, Taryn; Yildiz, Tugba; Betancourt, Tania; Shuster, Charles B.; Rogelj, Snezna; Rychlik, Blazej; Hudnall, Todd; Frolova, Liliya V.; Kornienko, Alexander

Aryl Substituted Benzimidazolones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2019-01-17

OAAI

Pribut, Nicole; Basson, Adriaan E.; van Otterlo, Willem A. L.; Liotta, Dennis C.; Pelly, Stephen C.

Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S

CHEMICAL SCIENCE

IF7.4

2019-01-01

OAAI

Lategahn, Jonas; Keul, Marina; Kloevekorn, Philip; Tumbrink, Hannah L.; Niggenaber, Janina; Mueller, Matthias P.; Hodson, Luke; Flasshoff, Maren; Hardick, Julia; Grabe, Tobias; Engel, Julian; Schultz-Fademrecht, Carsten; Baumann, Matthias; Ketzer, Julia; Muehlenberg, Thomas; Hiller, Wolf; Guenther, Georgia; Unger, Anke; Mueller, Heiko; Heimsoeth, Alena; Golz, Christopher; Blank-Landeshammer, Bernhard; Kollipara, Laxmikanth; Zahedi, Rene P.; Strohmann, Carsten; Hengstler, Jan G.; van Otterlo, Willem A. L.; Bauer, Sebastian; Rauh, Daniel

CAN-Mediated Oxidations for the Synthesis of Xanthones and Related Products (vol 75, pg 8701, 2010)

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2018-12-13

OAAI

Johnson, Myron M.; Naidoo, Jeremy M.; Fernandes, Manuel A.; Mmutlane, Edwin M.; van Otterlo, Willem A. L.; de Koning, Charles B.

Have lichenized fungi delivered promising anticancer small molecules?

PHYTOCHEMISTRY REVIEWS

IF7.6

2018-05-23

PREAI

Cimmino, Alessio; Nimis, Pier Luigi; Masi, Marco; De Gara, Laura; van Otterlo, Willem A. L.; Kiss, Robert; Evidente, Antonio; Lefranc, Florence

Developing Pantetheinase-Resistant Pantothenamide Antibacterials: Structural Modification Impacts on PanK Interaction and Mode of Action

ACS INFECTIOUS DISEASES

IF3.8

2018-01-14

PREAI

Barnard, Leanne; Mostert, Konrad J.; van Otterlo, Willem A. L.; Strauss, Erick

Alkaloids with Activity against the Zika Virus Vector Aedes aegypti (L.)-Crinsarnine and Sarniensinol, Two New Crinine and Mesembrine Type Alkaloids Isolated from the South African Plant Nerine sarniensis

MOLECULES

IF4.6

2016-10-27

OAAI

Masi, Marco; Cala, Antonio; Tabanca, Nurhayat; Cimmino, Alessio; Green, Ivan R.; Bloomquist, Jeffrey R.; van Otterlo, Willem A. L.; Macias, Francisco A.; Evidente, Antonio

Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2016-06-01

PREAI

Panayides, Jenny-Lee; Mathieu, Veronique; Banuls, Laetitia Moreno Y.; Apostolellis, Helen; Dahan-Farkas, Nurit; Davids, Hajierah; Harmse, Leonie; Rey, M. E. Christine; Green, Ivan R.; Pelly, Stephen C.; Kiss, Robert; Kornienko, Alexander; van Otterlo, Willem A. L.

研究方向