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马

马明亮 (Ming-Liang Ma)

east china normal university邮箱:mlma@brain.ecnu.edu.cn

H指数:17

被引数:855

个人简介

主要从事抗肿瘤药物的研发、新型功能材料的研发和应用，以及重要药物及其中间体的绿色合成工艺研究。2005年9月至2008年6月于华东师范大学获生理学博士学位，2002年9月至2005年6月于山东大学获化学硕士学位，1998年9月至2002年6月于山东大学获化学学士学位。2011年8月至今任华东师范大学副研究员，2015年8月至2017年8月挂职江苏省南通市如东县科技局副局长，2013年3月至2014年3月为美国亚利桑那大学药学院访问学者，2008年7月至2011年7月任华东师范大学助理研究员。

教育背景

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工作经历

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荣誉奖项

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Near-Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

近红外荧光PROTAC实现阿尔茨海默病中的诊疗成像和选择性Tau降解

Advanced Science

IF14.1

2026-09-020

OAAI

HDAC and PI3K Dual Inhibitors in The Treatment of Cancers: Current Status, Trends, and Solutions

HDAC和PI3K双抑制剂在癌症治疗中的现状、趋势与解决方案

European Journal of Medicinal Chemistry

IF5.9

2025-12-200

PRE

PI3K/mTOR Inhibitor Induces Context-Dependent Apoptosis and Methuosis in Cancer Cells

PI3K/mTOR抑制剂诱导肿瘤细胞发生情境依赖性凋亡和 Methuosis。

Pharmaceuticals 2025, Vol. 18, Page 1849

IF4.8

2025-12-050

OAAI

Discovery of Imidazo[1,2-b]pyridazine Derivatives as Potent PI3K/mTOR Dual Inhibitors for the Treatment of Pulmonary Fibrosis

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2025-12-010

PRE

Development of PI3K/mTOR-HSP90 Ligand Conjugates for Improved Colorectal Cancer Therapy

PI3K/mTOR-HSP90配体偶联物的开发以改善结直肠癌治疗

European Journal of Medicinal Chemistry

IF5.9

2025-10-250

PRE

Advances in clinical studies of peptide drugs in stroke disease

卒中疾病中肽类药物的临床研究进展

biochimica et biophysica acta molecular basis of disease

IF0

2025-07-030

PRE

A review on conductive polymers-modified TiO2 photocatalyst for environmental remediation

关于导电聚合物修饰的TiO2光催化剂在环境修复中的应用综述

JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING

IF7.2

2025-06-010

PRE

(-) - (11R, 12S)-mefloquine ameliorates neuropathic pain by modulating Cx36-ER stress interaction in the pain-related central nervous system in rats

IF5.1

2025-02-010

PRE

Targeting the PI3K/mTOR pathway in idiopathic pulmonary fibrosis: Advances and therapeutic potential

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2024-12-011

PRE

Design, Synthesis, and Evaluation of Small Fluorescent Molecules with a 1,1-Dimethylnaphthalen-2-(1H)-One Core

IF4.6

2024-07-191

OAAI

Hollow-polydopamine-nanocarrier-based near-infrared-light/pH-responsive drug delivery system for diffuse alveolar hemorrhage treatment

FRONTIERS IN CHEMISTRY

IF4.2

2023-06-152

OAAI

Function-oriented synthesis of Imidazo[1,2-a]pyrazine and Imidazo[1,2-b] pyridazine derivatives as potent PI3K/mTOR dual inhibitors

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-02-019

PRE

Multifunctional Polydopamine-Based Nanoparticles for Dual-Mode Imaging Guided Targeted Therapy of Lupus Nephritis

IF5.5

2022-09-2014

OAAI

Design, synthesis and activity study of a novel PI3K degradation by hijacking VHL E3 ubiquitin ligase

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2022-05-0119

PRE

Design, Synthesis, and Evaluation of Near-Infrared Fluorescent Molecules Based on 4H-1-Benzopyran Core

IF4.6

2021-11-190

OAAI

Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia

鼠尾草酚及其类似物减轻癌性恶病质引起的肌肉萎缩和脂肪分解

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

IF9.1

2021-05-0534

OAAI

Synthesis of γ-Keto Sulfones through a Three-Component Reaction of Cyclopropanols, DABCO . (SO2)2 and Alkyl Halides

ADVANCED SYNTHESIS & CATALYSIS

IF4

2021-04-2316

PREAI

Design, synthesis, and structure activity relationship (SAR) studies of novel imidazo [1,2-a] pyridine derivatives as Nek2 inhibitors

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2020-12-019

PREAI

Synthesis and fluorescent studies of a low molecular weight rotor for living cancer cell imaging

DYES AND PIGMENTS

IF4.2

2020-07-0112

PREAI

Delta opioid peptide [d-Ala2, d-Leu5] enkephalin confers neuroprotection by activating delta opioid receptor-AMPK-autophagy axis against global ischemia

Δ 阿片肽 [d-Ala2，d-Leu5] 脑啡肽通过激活 δ 阿片受体-AMPK-自噬轴发挥神经保护作用

CELL AND BIOSCIENCE

IF6.2

2020-06-1523

OAAI