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H

Haiming Zhang

Genentech

29H指数
144论文数
3.1K被引数
收录论文 68
发表时间
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Development of a Second-Generation Stereoselective Manufacturing Process for a Key N-Hydroxyamidine Intermediate of GDC-6599 Enabled by Data Science and Mechanistic Understanding通过数据科学和机理理解开发GDC-6599关键N-羟基脒中间体的第二代立体选择性制造工艺
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2026-06-29
err0
PREAI
errJacob C. Timmerman; Allen Y. Hong; Kurt Püntener; Anna-Lena Glass; Sandro Tonazzi; Katarzyna A. Piechowicz; Maud Guillemot-Plass; José G. Napolitano; Breanna Conklin; Haiming Zhang; Francis Gosselin
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Procyanidins Induce a Negative Priming Effect under Nitrogen Addition in an Acidic Tea Plantation Soil原花青素在施氮条件下诱导酸性茶园土壤产生负启动效应
errJournal of Soil Science and Plant Nutrition
IF3.1
err2026-04-27
err0
PREAI
errHanlin Mei; Haiming Zhang; Ningguo Zheng; Huaiying Yao
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A comparative study of portoenterostomy and choledochojejunostomy in New Zealand rabbits under immunosuppression在免疫抑制条件下对新西兰兔进行portoenterostomy和choledochojejunostomy的对比研究
errFrontiers in Surgery
IF1.8
err2025-12-18
err0
errOAAI
errSun, Jiuzheng; Zhang, Haiming; Huang, Hao; Qu, Wei; Zhu, Zhi-Jun
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C1 Functionalization of β-Carboline via Knochel-Hauser Base-Directed Metalation and Negishi Coupling
errJOURNAL OF ORGANIC CHEMISTRY
IF3.6
err2024-11-14
err0
PREAI
errTan, Jin; Clagg, Kyle; Zhang, Haiming
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Development of a First-Generation Stereocontrolled Manufacturing Process of TRPA1 Inhibitor GDC-6599
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2024-05-24
err0
PREAI
errHong, Allen Y.; Piechowicz, Katarzyna A.; Timmerman, Jacob C.; Zhang, Haiming; Molinaro, Carmela; Gosselin, Francis
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Enantioselective Sulfonimidamide Acylation via a Cinchona Alkaloid-Catalyzed Desymmetrization: Scope, Data Science, and Mechanistic Investigation
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-03-13
err5
errOAAI
errHaas, Brittany C.; Lim, Ngiap-Kie; Jermaks, Janis; Gaster, Eden; Guo, Melody C.; Malig, Thomas C.; Werth, Jacob; Zhang, Haiming; Toste, F. Dean; Gosselin, Francis; Miller, Scott J.; Sigman, Matthew S.
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Development of a Streamlined Manufacturing Process for the Highly Substituted Quinazoline Core Present in KRAS G12C Inhibitor Divarasib
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2024-01-09
err4
PREAI
errBurkhard, Johannes A.; Herold, Sebastian; Leitner, Christian; Zhang, Haiming; Angelaud, Remy; Tian, Qingping; Han, Chong; Gosselin, Francis
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Manufacturing Process for 6-Bromo-N,N-bis(4-methoxybenzyl)-4-methyl-5-(trifluoromethyl)pyridin-2-amine, a Key Intermediate in the Synthesis of KRAS G12C Inhibitor Divarasib合成KRAS G12C抑制剂Divarasib的关键中间体6-溴-N，N-双 (4-甲氧基苄基)-4-甲基-5-(三氟甲基) 吡啶-2-胺的制造工艺
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2023-12-29
err5
PREAI
errShen, Jeff; White, Nicholas A.; Tian, Qingping; Sirois, Lauren E.; Zhang, Haiming; Gosselin, Francis
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Data Science-Enabled Palladium-Catalyzed Enantioselective Aryl-Carbonylation of Sulfonimidamides
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-09-01
err19
PREAI
errvan Dijk, Lucy; Haas, Brittany C.; Lim, Ngiap-Kie; Clagg, Kyle; Dotson, Jordan J.; Treacy, Sean M.; Piechowicz, Katarzyna A.; Roytman, Vladislav A.; Zhang, Haiming; Toste, F. Dean; Miller, Scott J.; Gosselin, Francis; Sigman, Matthew S.
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Synthesis of a Highly Functionalized Quinazoline Organozinc toward KRAS G12C Inhibitor Divarasib (GDC-6036), Enabled through Continuous Flow Chemistry
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2023-08-24
err7
PREAI
errKelly, Sean M.; Lebl, Rene; Malig, Thomas C.; Bass, Thomas M.; Kummli, Dominique; Kaldre, Dainis; Orcel, Ugo; Trondlin, Lars; Linder, David; Sedelmeier, Joerg; Bachmann, Stephan; Han, Chong; Zhang, Haiming; Gosselin, Francis
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Practical Synthesis of Reactive Immuno-PET Linker-Chelator (1R,2R)-RESCA-TFP
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2023-06-28
err2
PREAI
errWong, Nicholas; Zhao, Eileen; Bao, Jiangyin; Koenig, Stefan G.; Molinaro, Carmela; Timmerman, Jacob C.; Zhang, Haiming; Sowell, C. Gregory; Gosselin, Francis
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Experience in the diagnosis and treatment of pneumonia caused by infection with Tropheryma whipplei: A case series
errHELIYON
IF3.6
err2023-06-01
err5
errOAAI
errFang, Zhixiong; Liu, Qiong; Tang, Wei; Yu, Hongyin; Zou, Min; Zhang, Haiming; Xue, Haiyan; Lin, Sha; Pei, Yi; Ai, Jingwen; Chen, Jun
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Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036第二代KRAS G12C共价抑制剂GDC-6036的选择性合成
errORGANIC LETTERS
IF5
err2023-05-10
err12
PREAI
errXu, Jie; Lim, Ngiap-Kie; Timmerman, Jacob C.; Shen, Jeff; Clagg, Kyle; Orcel, Ugo; Bigler, Raphael; Trachsel, Etienne; Meier, Roland; White, Nicholas A.; Burkhard, Johannes A.; Sirois, Lauren E.; Tian, Qingping; Angelaud, Remy; Bachmann, Stephan; Zhang, Haiming; Gosselin, Francis
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Significance of pyroptosis-related gene in the diagnosis and classification of rheumatoid arthritis
errFRONTIERS IN ENDOCRINOLOGY
IF4.6
err2023-03-15
err8
errOAAI
errLi, Jian; Cui, Yongfeng; Jin, Xin; Ruan, Hongfeng; He, Dongan; Che, Xiaoqian; Gao, Jiawei; Zhang, Haiming; Guo, Jiandong; Zhang, Jinxi
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Research progress on acupuncture treatment in central nervous system diseases based on NLRP3 inflammasome in animal models
errFRONTIERS IN NEUROSCIENCE
IF3.2
err2023-02-28
err6
errOAAI
errZhang, Hai-Ming; Luo, Dan; Chen, Rui; Wang, Shu-Han; Zhao, Ya-Juan; Li, Jin-Xiao; Zhou, Min-Feng; Yu, Zhao-Min; Zhang, Jun-Li; Liang, Feng-Xia
err分享
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High-Level Data Fusion Enables the Chemoinformatically Guided Discovery of Chiral Disulfonimide Catalysts for Atropselective Iodination of 2-Amino-6-arylpyridines
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2022-12-07
err19
PREAI
errRose, Brennan T.; Timmerman, Jacob C.; Bawel, Seth A.; Chin, Steven; Zhang, Haiming; Denmark, Scott E.
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Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2022-11-03
err26
PREAI
errXu, Jie; Grosslight, Samantha; Mack, Kyle A.; Nguyen, Sierra C.; Clagg, Kyle; Lim, Ngiap-Kie; Timmerman, Jacob C.; Shen, Jeff; White, Nicholas A.; Sirois, Lauren E.; Han, Chong; Zhang, Haiming; Sigman, Matthew S.; Gosselin, Francis
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Relationship between acupuncture and transient receptor potential vanilloid: Current and future directions
errFRONTIERS IN MOLECULAR NEUROSCIENCE
IF3.8
err2022-11-03
err5
errOAAI
errLuo, Dan; Liu, Li; Zhang, Hai-ming; Zhou, Yu-dian; Zhou, Min-feng; Li, Jin-xiao; Yu, Zhao-min; Chen, Rui; Liang, Feng-xia
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Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet-Spengler Condensation通过结晶驱动的非对映选择性pictet-spengler缩合的选择性雌激素受体降解GDC-9545 (giedestrant) 的有效制造工艺
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2021-11-09
err5
PREAI
errXu, Jie; Chung, Cheol K.; McClory, Andrew; Mack, Kyle A.; Dalziel, Michael E.; Fettes, Alec; Clagg, Kyle; Lim, Ngiap-Kie; Wuitschik, Georg; Jenny, Christian; Finet, Laure; Kammerer, Michael; Zhang, Haiming; Angelaud, Remy; Gosselin, Francis
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First-Generation Asymmetric Synthesis of the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) Featuring a Highly Efficient Pictet-Spengler Reaction and a C-N Coupling Reaction选择性雌激素受体降解GDC-9545 (Giredestrant) 的第一代不对称合成，具有高效的pictet-spengler反应和c-n偶联反应
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2021-11-05
err3
PREAI
errXu, Jie; Clagg, Kyle; Lim, Ngiap-Kie; Wuitschik, Georg; Chung, Cheol K.; Zhang, Haiming; Gosselin, Francis
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研究方向

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合作学者
合作期刊
K
K. N. Houk
H 指数: 157 · 论文数: 2.6K
F
F. Dean Toste
H 指数: 141 · 论文数: 801
R
Richard C. Larock
H 指数: 112 · 论文数: 1.0K
S
Scott E. Denmark
H 指数: 104 · 论文数: 969
M
Matthew S. Sigman
H 指数: 99 · 论文数: 578
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