Douglas A. Whittington - Publications, H-index & Citations

Diabetes is Not Significantly Associated with Decreased First-Line Tuberculosis Drug Exposure 糖尿病与一线抗结核药物暴露减少无显著关联

IF6.8

2025-03-04

OAAI

Cottrell, Kevin M.; Briggs, Kimberly J.; Tsai, Alice; Tonini, Matthew R.; Whittington, Douglas A.; Gong, Shanzhong; Liang, Colin; Mccarren, Patrick; Zhang, Minjie; Zhang, Wenhai; Huang, Alan; Maxwell, John P.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

IF4.3

2025-03-01

OAAI

Sturdy, Ann; Romano, Federico; Kipper, Karin; Barrett, Jessica; Whittington, Ashley; Kon, Onn Min; Oliver, Nick; Pasca, Oscar Della; Cooke, Graham

MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based Design MTA-协同PRMT5抑制剂：基于结构设计的机制转换

Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers

IF6.8

2025-02-07

OAAI

Cottrell, Kevin M.; Whittington, Douglas A.; Briggs, Kimberly J.; Jahic, Haris; Ali, Janid A.; Amor, Alvaro J.; Gotur, Deepali; Tonini, Matthew R.; Zhang, Wenhai; Huang, Alan; Maxwell, John P.

TNG348 is synergistic with PARP inhibitors in tumor models with elevated replication stress

IF6.8

2024-04-10

OAAI

Cottrell, Kevin M.; Briggs, Kimberly J.; Whittington, Douglas A.; Jahic, Haris; Ali, Janid A.; Davis, Charles B.; Gong, Shanzhong; Gotur, Deepali; Gu, Lina; McCarren, Patrick; Tonini, Matthew R.; Tsai, Alice; Wilker, Erik W.; Yuan, Hongling; Zhang, Minjie; Zhang, Wenhai; Huang, Alan; Maxwell, John P.

LIG1 inactivation selectively inhibits growth of BRCA1 mutant cells in vitro and in vivo

IF16.6

2024-03-22

PREAI

Simoneau, Antoine; Wu, Hsin-Jung; Pratt, Charlotte; Comer, Grace; Liu, Shangtao; Meier, Samuel; Khendu, Tenzing; Choi, Ashley; Zhang, Hongxiang; Shen, Binzhang; Whittington, Douglas; Sudsakorn, Sirimas; Zhang, Wenhai; Yu, Yi; Chen, Yingnan; Haines, Brian; Crystal, Adam; Andersen, Jannik N.; Maxwell, John; Throner, Scott

TNG917 is a clinical-grade, potent and selective inhibitor of EHMT1/2 for the treatment of immune cold tumors

IF16.6

2024-03-22

PREAI

Martires, Lauren; Ahronian, Leanne G.; Pratt, Charlotte; Das, Nikitha; Zhang, Xiaobin; Whittington, Douglas A.; Zhang, Hongxiang; Shen, Binzhang; Come, Jon; McCarren, Patrick; Liu, Mu-Sen; Min, Chengyin; Feng, Tianshu; Jahic, Haris; Brophy, Eric; Aird, Daniel; Andersen, Jannik N.; Huang, Alan; Li, Fang; Mallender, William D.; Nicholson, Hilary E.

Evaluation of the impact of homozygous MTAP truncations on the activity and selectivity of MTA-cooperative PRMT5 inhibitors

IF16.6

2024-03-22

PREAI

Lu, Alvin; Haines, Brian; Lei, Ji; Zhang, Wenhai; Zhang, Minjie; Whittington, Douglas A.; Ferdinez, Maria Lucia; Yu, Yi; Meier, Samuel R.; Choi, Ashley; Bejnood, Alborz; Bandi, Madhavi; Lazarides, Katherine; Pan, Xuewen; Gu, Lina; Tsai, Alice W.; Sudsakorn, Sirimas; Liang, Colin; Come, Jon; Williams, Brett; Throner, Scott; Vacca, Joseph; Maxwell, John P.; Anderson, Jannik N.; Huang, Alan; Min, Chengyin; Chen, Yingnan P.

TNG348, a selective USP1 inhibitor, shows strong preclinical combination activity with PARP inhibitors and other agents targeting DNA repair

IF16.6

2024-03-22

PREAI

Tonini, Matthew R.; Mignault, Andre A.; Whittington, Douglas A.; Lombardo, Steven A.; Shen, Binzhang; Stowe, Hannah; Yoda, Satoshi; Liu, Shangtao; Zhang, Minjie; Cottrell, Kevin M.; Meier, Samuel R.; Rego, Heidi; Morawiak, Jennifer; Hooper, Ellen; Yu, Yi; DiBenedetto, Heather; Crystal, Adam S.; Teng; Briggs, Kimberly

Characterization of the clinical development candidate TNG348 as a potent and selective inhibitor of USP1 for the treatment of BRCA1/2mut cancers

IF5.5

2023-12-01

PREAI

Simoneau, Antoine; Pratt, Charlotte; Corner, Grace; Wu, Hsin-Jung; Choi, Ashley; Khendu, Tenzing; Meier, Samuel; Yu, Yi; Liu, Shangtao; Zhang, Wenhai; Whittington, Douglas; Mallender, William; Sudsakorn, Sirimas; Chen, Yingnan; Haines, Brian; Throner, Scott; Crystal, Adam; Huang, Alan; Maxwell, John; Andersen, Jannik

Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer

IF16.6

2023-04-04

PREAI

Simoneau, Antoine; Wu, Hsin-Jung; Bandi, Madhavi; Lazarides, Katherine; Sun, Sining; Liu, Shangtao; Meier, Samuel; Choi, Ashley; Zhang, Hongxiang; Shen, Binzhang; Whittington, Douglas; Sudsakorn, Sirimas; Zhang, Wenhai; Yu, Yi; Liu, Yong; Liang, Colin; Palmieri, Michael; Chen, Yingnan; Haines, Brian; Tsai, Alice; Zhang, Minjie; Huang, Alan; Andersen, Jannik; Feng, Tianshu; Throner, Scott; Maxwell, John

VRK1 is a novel synthetic lethal target in VRK2-methylated glioblastoma

IF5.5

2022-10-12

OAAI

Simoneau, Antoine; Engel, Justin L.; Bandi, Madhavi; Lazarides, Katherine; Liu, Shangtao; Meier, Samuel R.; Choi, Ashley H.; Zhang, Hongxiang; Shen, Binzhang; Martires, Lauren; Gotur, Deepali; Pham, Truc, V; Li, Fang; Gu, Lina; Gong, Shanzhong; Zhang, Minjie; Wilker, Erik; Pan, Xuewen; Whittington, Douglas A.; Throner, Scott; Maxwell, John P.; Chen, Yingnan; Yu, Yi; Huang, Alan; Andersen, Jannik N.; Feng, Tianshu

Loss of HS2ST1 cooperates with MAPK inhibition to impair growth of mesenchymal KRAS mutant NSCLC

IF5.5

2021-12-01

PREAI

Shields, Julie; Meier, Samuel R.; Engel, Justin; Bandi, Madhavi; Ferdinez, Maria L. Dam; Zhang, Wenhai; Zhao, Shan-Chuan; Zhang, Minjie; Choi, Ashley; Yu, Yi; Pan, Xuewen; McMillan, Brian; Williams, Brett; Sjin, Robert Tjin Tham; Whittington, Douglas; Wilker, Erik; Huang, Alan; Li, Fang; Emmanuel, Natasha

Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

IF5.5

2021-12-01

PREAI

Ahronian, Leanne G.; Fenoglio, Silvia; Das, Nikitha; Aird, Daniel; Guerin, David; Whittington, Douglas; Jahic, Haris; Brophy, Erin; McCarren, Patrick; McMillan, Brian; Tepper, James; Mentzer, Michaela; Li, Fang; Zhang, Hongxiang; Pan, Xuewen; Maxwell, John; Andersen, Jannik; Huang, Alan; Sjin, Robert Tjin Tham

Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2

IF6.8

2019-12-10

511

OAAI

Lanman, Brian A.; Allen, Jennifer R.; Allen, John G.; Amegadzie, Albert K.; Ashton, Kate S.; Booker, Shon K.; Chen, Jian Jeffrey; Chen, Ning; Frohn, Michael J.; Goodman, Guy; Kopecky, David J.; Liu, Longbin; Lopez, Patricia; Low, Jonathan D.; Ma, Vu; Minatti, Ana E.; Nguyen, Thomas T.; Nishimura, Nobuko; Pickrell, Alexander J.; Reed, Anthony B.; Shin, Youngsook; Siegmund, Aaron C.; Tamayo, Nuria A.; Tegley, Christopher M.; Walton, Mary C.; Wang, Hui-Ling; Wurz, Ryan P.; Xue, May; Yang, Kevin C.; Achanta, Pragathi; Bartberger, Michael D.; Canon, Jude; Hollis, L. Steven; McCarter, John D.; Mohr, Christopher; Rex, Karen; Saiki, Anne Y.; San Miguel, Tisha; Volak, Laurie P.; Wang, Kevin H.; Whittington, Douglas A.; Zech, Stephan G.; Lipford, J. Russell; Cee, Victor J.

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

IF6.8

2019-10-07

PREAI

Pettus, Liping H.; Bourbeau, Matthew P.; Bradley, Jodi; Bartberger, Michael D.; Chen, Kui; Hickman, Dean; Johnson, Michael; Liu, Qingyian; Manning, James R.; Nanez, Adrian; Siegmund, Aaron C.; Wen, Paul H.; Whittington, Douglas A.; Allen, Jennifer R.; Wood, Stephen

CANCER DISCOVERY

IF33.3

2018-12-03

357

OAAI

Caenepeel, Sean; Brown, Sean P.; Belmontes, Brian; Moody, Gordon; Keegan, Kathleen S.; Chui, Danny; Whittington, Douglas A.; Huang, Xin; Poppe, Leszek; Cheng, Alan C.; Cardozom, Mario; Houze, Jonathan; Li, Yunxiao; Lucas, Brian; Paras, Nick A.; Wang, Xianghong; Taygerly, Joshua P.; Vimolratana, Marc; Zancanella, Manuel; Zhu, Liusheng; Cajulis, Elaina; Osgood, Tao; Sun, Jan; Damon, Leah; Egan, Regina K.; Greninger, Patricia; McClanaghan, Joseph D.; Gong, Jianan; Moujalled, Donia; Pomilio, Giovanna; Beltran, Pedro; Benes, Cyril H.; Roberts, Andrew W.; Huang, David C.; Wei, Andrew; Canon, Jude; Coxon, Angela; Hughes, Paul E.

Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase (vol 59, pg 3732, 2016)

Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridiny1)-4-quinolinecarboxamide (AM-1430)

IF6.8

2017-03-28

OAAI

Jordan, John B.; Whittington, Douglas A.; Bartberger, Michael D.; Sickmier, E. Allen; Chen, Kui; White, Ryan D.; Cheng, Yuan; Judd, Ted