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J

John P. Maxwell

tango therapeutics
H指数:13
被引数:769

个人简介

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荣誉奖项

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MTA-Cooperative PRMT5 Inhibitors Demonstrate Efficacy in MTAP-Deleted MPNST Models and Enhance Chemotherapy Response

MTA协同的PRMT5抑制剂在MTAP缺失的MPNST模型中显示出疗效并增强化疗反应

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Zhang, Xiaochun; Borcherding, Dana; Zhang, Minjie; Lyn, Yang; Wang, Guangfeng; He, Kevin; Oztosun, Gorkem; Sachdeva, Ishita; Yang, Liuzhan; Yang, Kuangying; Yuen, Alex; Dibenedetto, Heather; Tsai, Alice; Huang, Alan; Maxwell, John; Cottrell, Kevin; Briggs, Kimberly; Hirbe, Angela
Discovery of TNG-6132, a potent, selective, and orally bioavailable USP1 inhibitor

TNG-6132的发现，一种强效、选择性且口服生物利用度高的USP1抑制剂

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
2025-05-150
PRE
Throner, Scott; Feng, Tianshu; Andersen, Jannik N.; Bandi, Madhavi; Engel, Justin L.; Gong, Shanzhong; Gotur, Deepali; Gu, Lina; Huang, Alan; Lazarides, Katherine; Maxwell, John P.; McCarren, Patrick; McMillan, Brian J.; Pham, Truc, V; Simoneau, Antoine; Tsai, Alice; Whittington, Douglas A.; Wilker, Erik; Zhang, Minjie; Zhang, Wenhai
Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-04-1010
OAAI
Cottrell, Kevin M.; Briggs, Kimberly J.; Whittington, Douglas A.; Jahic, Haris; Ali, Janid A.; Davis, Charles B.; Gong, Shanzhong; Gotur, Deepali; Gu, Lina; McCarren, Patrick; Tonini, Matthew R.; Tsai, Alice; Wilker, Erik W.; Yuan, Hongling; Zhang, Minjie; Zhang, Wenhai; Huang, Alan; Maxwell, John P.
TNG917 is a clinical-grade, potent and selective inhibitor of EHMT1/2 for the treatment of immune cold tumors
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Lu, Alvin; Haines, Brian; Lei, Ji; Zhang, Wenhai; Zhang, Minjie; Whittington, Douglas A.; Ferdinez, Maria Lucia; Yu, Yi; Meier, Samuel R.; Choi, Ashley; Bejnood, Alborz; Bandi, Madhavi; Lazarides, Katherine; Pan, Xuewen; Gu, Lina; Tsai, Alice W.; Sudsakorn, Sirimas; Liang, Colin; Come, Jon; Williams, Brett; Throner, Scott; Vacca, Joseph; Maxwell, John P.; Anderson, Jannik N.; Huang, Alan; Min, Chengyin; Chen, Yingnan P.
Unbiased in vitro and in vivo drug anchor screens identify mechanisms of resistance and sensitization for MTA-cooperative PRMT5 inhibitors in MTAP-deleted cancer models
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Lombardo, Steven; Tonini, Matthew R.; Grove, Lauren; Fenoglio, Silvia; Tepper, James; Shen, Binzhang; Stowe, Hannah; Liu, Shangtao; Meier, Samuel R.; Choi, Ashley H.; Khendu, Tenzing; Yu, Yi; Cottrell, Kevin M.; Maxwell, John P.; Andersen, Jannik N.; Huang, Alan; Briggs, Kimberly J.; Teng, Teng
TNG348, a selective USP1 inhibitor, shows strong preclinical combination activity with PARP inhibitors and other agents targeting DNA repair
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-012
PRE
Simoneau, Antoine; Pratt, Charlotte; Corner, Grace; Wu, Hsin-Jung; Choi, Ashley; Khendu, Tenzing; Meier, Samuel; Yu, Yi; Liu, Shangtao; Zhang, Wenhai; Whittington, Douglas; Mallender, William; Sudsakorn, Sirimas; Chen, Yingnan; Haines, Brian; Throner, Scott; Crystal, Adam; Huang, Alan; Maxwell, John; Andersen, Jannik
Characterization of the clinical development candidate TNG348 as a potent and selective inhibitor of USP1 for the treatment of BRCA1/2mut cancers
CANCER RESEARCH
IF16.6
2023-04-042
PRE
Simoneau, Antoine; Wu, Hsin-Jung; Bandi, Madhavi; Lazarides, Katherine; Sun, Sining; Liu, Shangtao; Meier, Samuel; Choi, Ashley; Zhang, Hongxiang; Shen, Binzhang; Whittington, Douglas; Sudsakorn, Sirimas; Zhang, Wenhai; Yu, Yi; Liu, Yong; Liang, Colin; Palmieri, Michael; Chen, Yingnan; Haines, Brian; Tsai, Alice; Zhang, Minjie; Huang, Alan; Andersen, Jannik; Feng, Tianshu; Throner, Scott; Maxwell, John
Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer
MOLECULAR CANCER THERAPEUTICS
IF5.5
2022-10-1231
OAAI
Simoneau, Antoine; Engel, Justin L.; Bandi, Madhavi; Lazarides, Katherine; Liu, Shangtao; Meier, Samuel R.; Choi, Ashley H.; Zhang, Hongxiang; Shen, Binzhang; Martires, Lauren; Gotur, Deepali; Pham, Truc, V; Li, Fang; Gu, Lina; Gong, Shanzhong; Zhang, Minjie; Wilker, Erik; Pan, Xuewen; Whittington, Douglas A.; Throner, Scott; Maxwell, John P.; Chen, Yingnan; Yu, Yi; Huang, Alan; Andersen, Jannik N.; Feng, Tianshu

研究方向

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K
Kevin M. Cottrell
H 指数:12论文数:47被引数:705
A
Alan Huang
H 指数:35论文数:352被引数:8,888
J
Jannik N. Andersen
H 指数:29论文数:200被引数:5,656
D
Douglas A. Whittington
H 指数:42论文数:245被引数:5,869
W
Wenhai Zhang
H 指数:21论文数:94被引数:1,350
K
Kimberly J. Briggs
H 指数:13论文数:53被引数:2,907
S
Samuel R. Meier
H 指数:38论文数:189被引数:2.3万
S
Scott Throner
H 指数:4论文数:55被引数:102
Y
Yi Yu
H 指数:10论文数:133被引数:549
A
Ashley H. Choi
H 指数:4论文数:77被引数:110