Steven A. Spronk - Publications, H-index & Citations

Steven A. Spronk

bristol myers squibb

13H指数

25论文数

620被引数

收录论文 16

发表时间

Discovery of Non-prostanoid EP4 Agonists for the Treatment of Inflammatory Bowel Disease 非前列腺素类EP4激动剂的发现及其在炎症性肠病治疗中的应用

Journal of Medicinal Chemistry

IF6.8

2026-04-03

PREAI

Heidi L. Perez; Sunita Dewnani; Steven A. Spronk; Hai-Yun Xiao; Ling Li; Mojgan Abousleiman; Chi Shing Sum; Margarita Garcia-Calvo; Fei Yu; Brian Anderson; Brian J. Arey; Riyaz Khan; Chandra Sekhar Bokka; Yazh Muthukumar; Kaushik Ghosh; Tao Wang; Carol M. Krause; Judith Murray; Trevor Vernon; Ramakrishna Chandran; Mary T. Obermeier; Victor R. Guarino; Tamara King; Julia Li; Laura Armstrong; Purnima Khandelwal; Margaret Prack; David Marcoux; Samuel Gerritz; William J. Pitts; Alaric J. Dyckman; Robert M. Borzilleri; Carolyn Dzierba; Jenny H. Xie; Mary Struthers; Patrick Shaw; Derek Holmes; Amy C. Hart; Trevor C. Sherwood

Discovery of liver-selective glucokinase activators comprising N-(4-alkylthiazol-2-yl)benzamides and N-(3-alkyl-1,2,4-thiadiazol-5-yl) benzamides for the treatment of metabolic disorders 肝选择性葡萄糖激酶激活剂的发现，包括N-(4-烷基硫唑-2-基)苯甲酰胺和N-(3-烷基-1,2,4-噻二唑-5-基)苯甲酰胺，用于治疗代谢紊乱

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

IF2.2

2025-07-01

PREAI

Yoon, David S.; Wu, Shung; Chen, Sean S.; Smirk, Rebecca A.; Brigance, Robert P.; Meng, Wei; Shi, Yan; Tao, Shiwei; Wang, Ying; Zhang, Hao; Mathur, Arvind; Catanio, Helen Grace; Kalinowski, Stephen; Zebo, Rachel; Zalaznick, Jacob; Taylor, Joseph; Zinker, Bradley; Kopcho, Lisa M.; Behnia, Kamelia; Xu, Carrie; Spronk, Steven A.; Yang, Yanou; Josephs, Jonathan; Janovitz, Evan B.; Marathe, Punit; Whaley, Jean; Barrish, Joel C.; Kirby, Mark; Cheng, Peter T. W.

A physics-aware neural network for protein-ligand interactions with quantum chemical accuracy

CHEMICAL SCIENCE

IF7.4

2024-01-01

OAAI

Glick, Zachary L.; Metcalf, Derek P.; Glick, Caroline S.; Spronk, Steven A.; Koutsoukas, Alexios; Cheney, Daniel L.; Sherrill, C. David

Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-02-18

PREAI

Shi, Yan; Wang, Ying; Meng, Wei; Brigance, Robert P.; Ryono, Denis E.; Bolton, Scott; Zhang, Hao; Chen, Sean; Smirk, Rebecca; Tao, Shiwei; Tino, Joseph A.; Williams, Kristin N.; Sulsky, Richard; Nielsen, Laura; Ellsworth, Bruce; Wong, Michael K. Y.; Sun, Jung-Hui; Leith, Leslie W.; Sun, Dawn; Wu, Dauh-Rurng; Gupta, Anuradha; Rampulla, Richard; Mathur, Arvind; Chen, Bang-Chi; Wang, Aiying; Fuentes-Catanio, Helen G.; Kunselman, Lori; Cap, Michael; Zalaznick, Jacob; Ma, Xiaohui; Liu, Heng; Taylor, Joseph R.; Zebo, Rachel; Jones, Beverly; Kalinowski, Stephen; Swartz, Joann; Staal, Ada; O'Malley, Kevin; Kopcho, Lisa; Muckelbauer, Jodi K.; Krystek, Stanley R.; Spronk, Steven A.; Marcinkeviciene, Jovita; Everlof, Gerry; Chen, Xue-Qing; Xu, Carrie; Li, Yi-Xin; Langish, Robert A.; Yang, Yanou; Wang, Qi; Behnia, Kamelia; Fura, Aberra; Janovitz, Evan B.; Pannacciulli, Nicola; Griffen, Steven; Zinker, Bradley A.; Krupinski, John; Kirby, Mark; Whaley, Jean; Zahler, Robert; Barrish, Joel C.; Robl, Jeffrey A.; Cheng, Peter T. W.

CLIFF: A component-based, machine-learned, intermolecular force field

JOURNAL OF CHEMICAL PHYSICS

IF3.1

2021-05-14

PREAI

Schriber, Jeffrey B.; Nascimento, Daniel R.; Koutsoukas, Alexios; Spronk, Steven A.; Cheney, Daniel L.; Sherrill, C. David

Electron-Passing Neural Networks for Atomic Charge Prediction in Systems with Arbitrary Molecular Charge

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2020-12-16

OAAI

Metcalf, Derek P.; Jiang, Andy; Spronk, Steven A.; Cheney, Daniel L.; Sherrill, C. David

Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2020-11-01

PREAI

Shaw, Scott A.; Vokits, Benjamin P.; Dilger, Andrew K.; Viet, Andrew; Clark, Charles G.; Abell, Lynn M.; Locke, Gregory A.; Duke, Gerald; Kopcho, Lisa M.; Dongre, Ashok; Gao, Ji; Krishnakumar, Arathi; Jusuf, Sutjano; Khan, Javed; Spronk, Steven A.; Basso, Michael D.; Zhao, Lei; Cantor, Glenn H.; Onorato, Joelle M.; Wexler, Ruth R.; Duclos, Franck; Kick, Ellen K.

AP-Net: An atomic-pairwise neural network for smooth and transferable interaction potentials

JOURNAL OF CHEMICAL PHYSICS

IF3.1

2020-07-27

PREAI

Glick, Zachary L.; Metcalf, Derek P.; Koutsoukas, Alexios; Spronk, Steven A.; Cheney, Daniel L.; Sherrill, C. David

Approaches for machine learning intermolecular interaction energies and application to energy components from symmetry adapted perturbation theory

JOURNAL OF CHEMICAL PHYSICS

IF3.1

2020-02-19

OAAI

Metcalf, Derek P.; Koutsoukas, Alexios; Spronk, Steven A.; Claus, Brian L.; Loughney, Deborah A.; Johnson, Stephen R.; Cheney, Daniel L.; Sherrill, C. David

Improving Accuracy, Diversity, and Speed with Prime Macrocycle Conformational Sampling

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2017-08-08

PREAI

Sindhikara, Dan; Spronk, Steven A.; Day, Tyler; Borrelli, Ken; Cheney, Daniel L.; Posy, Shana L.

4-Benzothiazole-7-hydroxyindolinyl Diaryl Ureas Are Potent P2Y1 Antagonists with Favorable Pharmacokinetics: Low Clearance and Small Volume of Distribution

CHEMMEDCHEM

IF3.4

2014-07-02

PREAI

Qiao, Jennifer X.; Wang, Tammy C.; Hiebert, Sheldon; Hu, Carol H.; Schumacher, William A.; Spronk, Steven A.; Clark, Charles G.; Han, Ying; Hua, Ji; Price, Laura A.; Shen, Hong; Chacko, Silvi A.; Everlof, Gerry; Bostwick, Jeffrey S.; Steinbacher, Thomas E.; Li, Yi-Xin; Huang, Christine S.; Seiffert, Dietmar A.; Rehfuss, Robert; Wexler, Ruth R.; Lam, Patrick Y. S.

Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1-(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y1 Antagonist

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2013-11-12

PREAI

Qiao, Jennifer X.; Wang, Tammy C.; Ruel, Rejean; Thibeault, Carl; L'Heureux, Alexandre; Schumacher, William A.; Spronk, Steven A.; Hiebert, Sheldon; Bouthillier, Gilles; Lloyd, John; Pi, Zulan; Schnur, Dora M.; Abell, Lynn M.; Hua, Ji; Price, Laura A.; Liu, Eddie; Wu, Qimin; Steinbacher, Thomas E.; Bostwick, Jeffrey S.; Chang, Ming; Zheng, Joanna; Gao, Qi; Ma, Baoqing; McDonnell, Patricia A.; Huang, Christine S.; Rehfuss, Robert; Wexler, Ruth R.; Lam, Patrick Y. S.

The role of tyrosine 71 in modulating the flap conformations of BACE1

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

IF2.8

2011-05-16

OAAI

Spronk, Steven A.; Carlson, Heather A.

Voltage-dependent hydration and conduction properties of the hydrophobic pore of the mechanosensitive channel of small conductance

BIOPHYSICAL JOURNAL

IF3.1

2006-05-01

OAAI

Spronk, SA; Elmore, DE; Dougherty, DA

Reaction of NH (X) with oxygen in a solid xenon matrix: Formation and infrared spectrum of imine peroxide, HNOO

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

1998-11-20

PREAI

Laursen, SL; Grace, JE; DeKock, RL; Spronk, SA

Discovery of Potent and Selective Reversible Ubiquitin-Like Modifier Activating Enzyme 5 Inhibitors Targeting the UFMylation Pathway 发现靶向UFMylation通路的高效、选择性可逆泛素样修饰激活酶5抑制剂

Journal of Medicinal Chemistry

IF6.8

PREAI

James J. Mignone; Elizabeth A. Jurica; Deepa Rajasekaran; Jaclyn Robustelli; Courtney McCarthy; Phong Q. Quang; Qi Guo; Darby J. Ball; Andrew F. Donnell; Brian P. Mahon; Dawn Mulligan; Steven A. Spronk; Shivangi Srivastava; Erik C. Vik; Cullen L. Cavallaro; Farya J. Chattergoon; Bruce A. Ellsworth; Shriya Joshi; Emma Lees; R. Michael Lawrence; Ling Li; Selyna Mai; Mohammad K. Manik; Frank Marsilio; Konstantinos Mavrakis; Paramasivam Murugan; John A. Newitt; Payal Sheth; Jeffrey Tredup; Sarah C. Traeger; David D. Weis; Chunhong Yan; Joseph Yanchunas Jr.; Ping Zhang; Stephen T. Wrobleski; Peter Kalev; Joanne J. Bronson

研究方向