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Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models Lizzadro, Luca; Li, Jiapeng; Taha, Taha Y.; Degotte, Gilles; Detomasi, Tyler C.; Zapatero-Belinchon, Francisco J.; Hantz, Eric R.; Huang, Sijie; Matsui, Yusuke; Henderson, Will R.; McCann, Jack T.; Montano, Mauricio; Rosecrans, Julia; Torres Pomares, Daniel F.; McGovern, Briana L.; Diaz-Tapia, Randy; Benjamin, Jared; Gordon, Mary E.; Suazo, Isidora D.; Settineri, Nicholas S.; Diallo, Amy; Krogan, Nevan J.; Shoichet, Brian K.; Verba, Kliment A.; Albrecht, Randy; Garcia-Sastre, Adolfo; White, Kris M.; Ott, Melanie; Craik, Charles S.; Renslo, Adam R. 分享 收藏
Real-time in vivo imaging of therapeutic bio-distribution with a miniaturized, implantable fluorescence imager 使用微型化、可植入荧光成像仪进行实时活体治疗生物分布成像 Roschelle, Micah; Mehta, Abijeet Singh; Bartley, Jack; Rabbani, Rozhan; Harris, Lukas; Qiu, Longhui; Zhang, Hui; Serrano, Juan Antonio Camara; Daschowdhury, Kingshuk; Chuo, Shih-Wei; Craik, Charles S.; Niknejad, Ali; Anwar, Mekhail 分享 收藏
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Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy 基于结构的具有高生物利用度、共价键、广谱冠状病毒MPro抑制剂的发现，并具有强体内效力 Detomasi, Tyler C.; Degotte, Gilles; Huang, Sijie; Suryawanshi, Rahul K.; Diallo, Amy; Lizzadro, Luca; Zaptero-Belinchon, Francisco J.; Taha, Taha Y.; Li, Jiapeng; Richards, Alicia L.; Hantz, Eric R.; Alam, Zain; Montano, Mauricio; McCavitt-Malvido, Maria; Gumpena, Rajesh; Partridge, James R.; Correy, Galen J.; Matsui, Yusuke; Charvat, Annemarie F.; Glenn, Isabella S.; Rosecrans, Julia; Revalde, Jezrael L.; Anderson, Dashiell; Hultquist, Judd F.; Arkin, Michelle R.; Neitz, R. Jeffrey; Swaney, Danielle L.; Krogan, Nevan J.; Shoichet, Brian K.; Verba, Kliment A.; Ott, Melanie; Renslo, Adam R.; Craik, Charles S. 分享 收藏
On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents 在树脂上组装新型抗新型隐球菌May1大环抑制剂：通往强效抗真菌药物的一条途径 Krystufek, Robin; Verner, Vaclav; Sacha, Pavel; Hadzima, Martin; Trajhan, Filip; Starkova, Jana; Tloustova, Eva; Dvorakova, Alexandra; Pecina, Adam; Brynda, Jiri; Chalupsky, Karel; Hajek, Miroslav; Boucher, Michael J.; Majer, Pavel; Rezac, Jan; Madhani, Hiten D.; Craik, Charles S.; Konvalinka, Jan 分享 收藏
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Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP Nadel, Cory M.; Pokhrel, Saugat; Wucherer, Kristin; Oehler, Abby; Thwin, Aye C.; Basu, Koli; Callahan, Matthew D.; Southworth, Daniel R.; Mordes, Daniel A.; Craik, Charles S.; Gestwicki, Jason E. 分享 收藏
Imaging the Granzyme Mediated Host Immune Response to Viral and Bacterial Pathogens In Vivo Using Positron Emission Tomography Pandey, Apurva; Chopra, Shalini; Cleary, Simon J.; Lopez-Alvarez, Marina; Quimby, Fiona M.; Alanizi, Aryn A. A.; Sakhamuri, Sasank; Zhang, Ningjing; Looney, Mark R.; Craik, Charles S.; Wilson, David M.; Evans, Michael J. 分享 收藏
Structural basis of prostaglandin efflux by MRP4 MRP4对前列腺素外排的结构基础 Pourmal, Sergei; Green, Evan; Bajaj, Ruchika; Chemmama, Ilan E.; Knudsen, Giselle M.; Gupta, Meghna; Sali, Andrej; Cheng, Yifan; Craik, Charles S.; Kroetz, Deanna L.; Stroud, Robert M. 分享 收藏
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Rare antibody phage isolation and discrimination (RAPID) biopanning enables identification of high-affinity antibodies against challenging targets Chung, Dong Hee; Kong, Sophie; Young, Nicholas J.; Chuo, Shih-Wei; Shiah, Jamie V.; Connelly, Emily J.; Rohweder, Peter J.; Born, Alexandra; Manglik, Aashish; Grandis, Jennifer R.; Johnson, Daniel E.; Craik, Charles S. 分享 收藏
Mutations in a-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases (vol 18, 29, 2023) Sampognaro, Paul J.; Arya, Shruti; Knudsen, Giselle M.; Gunderson, Emma L.; Sandoval-Perez, Angelica; Hodul, Molly; Bowles, Kathryn; Craik, Charles S.; Jacobson, Matthew P.; Kao, Aimee W. 分享 收藏
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases Sampognaro, Paul J.; Arya, Shruti; Knudsen, Giselle M.; Gunderson, Emma L.; Sandoval-Perez, Angelica; Hodul, Molly; Bowles, Katherine; Craik, Charles S.; Jacobson, Matthew P.; Kao, Aimee W. 分享 收藏
High-throughput optofluidic screening of single B cells identifies novel cross-reactive antibodies as inhibitors of uPAR with antibody-dependent effector functions Lourenco, Andre Luiz; Chuo, Shih-Wei; Bohn, Markus F.; Hann, Byron; Khan, Shireen; Yevalekar, Neha; Patel, Nitin; Yang, Teddy; Xu, Lina; Lv, Dandan; Drakas, Robert; Lively, Sarah; Craik, Charles S. 分享 收藏
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