Andrew J. Wiemer - Publications, H-index & Citations

Andrew J. Wiemer

University of Connecticut

29H指数

96论文数

2.2K被引数

收录论文 53

发表时间

NanoBRET Saturation Analysis with a Novel HaloTag Ligand Reveals Butyrophilin Heteromeric Interactions Controlling γ9δ2 T Cell Activation 利用新型HaloTag配体进行NanoBRET饱和分析，揭示了调控γ9δ2 T细胞活化的乳脂球蛋白异源二聚体相互作用

ACS Chemical Biology

IF3.8

2026-06-18

PREAI

Girija Pawge; Sidra Bashir; Ritika Parikh; Chia-Hung Christine Hsiao; Andrew J. Wiemer

Benzoic Acid Derivatives Improve Plasma Stability of Diester Butyrophilin Ligand Prodrugs 苯甲酸衍生物改善二酯类但酪蛋白配体前药的血浆稳定性

Journal of Medicinal Chemistry

IF6.8

2026-02-12

OAAI

Parker A. Kintigh; Umed Singh; Girija Pawge; Sidra Bashir; Chia-Hung Christine Hsiao; Andrew J. Wiemer; David F. Wiemer

Cell stress activates γ9δ2 T cells via endogenous phosphoantigens and butyrophilin complex dynamics

Biomedicine & Pharmacotherapy

IF7.5

2026-01-22

OAAI

Yiming Jin; Khiem Nguyen; Sidra Bashir; Girija Pawge; Reagan M. Strand; Chia-Hung Christine Hsiao; Olga Vinogradova; Andrew J. Wiemer

Molecular glues evolve from serendipity to rational design 分子胶从偶然发现发展到理性设计

Trends in Pharmacological Sciences

IF19.9

2025-12-03

PREAI

Princy Shrivastav; Rohit Singh; Andrew J. Wiemer

γ9δ2 T cells detect mevalonate diphosphate via BTN3A3 γ9δ2 T细胞通过BTN3A3检测甲羟戊二磷酸二酯。

Cellular and Molecular Life Sciences

IF6.2

2025-11-14

OAAI

Yiming Jin; Khiem Nguyen; Girija Pawge; Chia-Hung Christine Hsiao; Olga Vinogradova; Andrew J. Wiemer

Anti-TIGIT therapies: a review of preclinical and clinical efficacy and mechanisms 抗TIGIT疗法：对临床前和临床疗效及机制的综述

cancer immunology immunotherapy

IF0

2025-07-15

OAAI

Erin C. Sundstrom; Xueting Huang; Andrew J. Wiemer

Synthesis and evaluation of triazole-containing aryl/acyloxy prodrugs of a BTN3A1 ligand

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2025-04-01

PREAI

Singh, Umed; Pawge, Girija; Kintigh, Parker A.; Sarno, Joseph P.; Rani, Sarita; Hsiao, Chia-Hung Christine; Wiemer, Andrew J.; Wiemer, David F.

Investigation of structural and dynamic properties of the Butyrophilin BTN3A1/BTN2A1 cytoplasmic complex by 19F solution NMR

FASEB JOURNAL

IF4.2

2025-03-31

PREAI

Nguyen, Khiem; Hsiao, Chia-Hung Christine; Jin, Yiming; Wiemer, Andrew J.; Vinogradova, Olga

PVR exposure influences the activation, adhesion, and protein expression of human CD8+T cells, including the CD96-mediated transfer of PVR

JOURNAL OF IMMUNOLOGY

IF3.4

2025-01-23

OAAI

Huang, Xueting; Pawge, Girija; Snicer, Christina E.; Hsiao, Chia-Hung Christine; Wiemer, Andrew J.

Synthesis and evaluation of (E)-4-hydroxy-3-methyl-but-2-enyl E )-4-hydroxy-3-methyl-but-2-enyl diphosphate analogs as competitive partial agonists of butyrophilin 3A1

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-10-01

PREAI

Singh, Rohit; Rani, Sarita; Jin, Yiming; Hsiao, Chia-Hung Christine; Wiemer, Andrew J.

Enhanced Plasma Stability and Potency of Aryl/Acyloxy Prodrugs of a BTN3A1 Ligand

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2024-09-25

PREAI

Singh, Umed; Pawge, Girija; Rani, Sarita; Hsiao, Chia-Hung Christine; Wiemer, David F.; Wiemer, Andrew J.

A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human γδ T cell phosphoantigen sensing 由近膜区域控制的BTN3A IgV和B30.2结构域的独特拓扑结构有利于最佳的人 γ δ T细胞磷酸抗原感应

NATURE COMMUNICATIONS

IF15.7

2023-11-22

OAAI

Karunakaran, Mohindar M.; Subramanian, Hariharan; Jin, Yiming; Mohammed, Fiyaz; Kimmel, Brigitte; Juraske, Claudia; Starick, Lisa; Noehren, Anna; Laender, Nora; Willcox, Carrie R.; Singh, Rohit; Schamel, Wolfgang W.; Nikolaev, Viacheslav O.; Kunzmann, Volker; Wiemer, Andrew J.; Willcox, Benjamin E.; Herrmann, Thomas

Diester Prodrugs of a Phosphonate Butyrophilin Ligand Display Improved Cell Potency, Plasma Stability, and Payload Internalization

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-11-07

OAAI

Singh, Umed; Pawge, Girija; Rani, Sarita; Hsiao, Chia-Hung Christine; Wiemer, Andrew J.; Wiemer, David F.

Mutations to the BTN2A1 Linker Region Impact Its Homodimerization and Its Cytoplasmic Interaction with Phospho-Antigen-Bound BTN3A1

JOURNAL OF IMMUNOLOGY

IF3.4

2023-05-12

PREAI

Nguyen, Khiem; Jin, Yiming; Howell, Matthew; Hsiao, Chia-Hung Christine; Wiemer, Andrew J.; Vinogradova, Olga

Discovery of TIGIT inhibitors by phage display

JOURNAL OF IMMUNOLOGY

IF3.4

2023-05-01

OAAI

Huang, Xueting; Hsiao, Chia-Hung Christine; Wiemer, Andrew J.

New Technologies Bloom Together for Bettering Cancer Drug Conjugates

PHARMACOLOGICAL REVIEWS

IF17.3

2022-07-01

OAAI

Jin, Yiming; Zakeri, Shahab Edalatian; Bahal, Raman; Wiemer, Andrew J.

Ligand-induced interactions between butyrophilin 2A1 and 3A1 internal domains in the HMBPP receptor complex

CELL CHEMICAL BIOLOGY

IF7.2

2022-06-01

OAAI

Hsiao, Chia-Hung Christine; Nguyen, Khiem; Jin, Yiming; Vinogradova, Olga; Wiemer, Andrew J.

Synthesis and Metabolism of BTN3A1 Ligands: Studies on Diene Modifications to the Phosphoantigen Scaffold

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2022-01-27

OAAI

Harmon, Nyema M.; Poe, Michael M.; Huang, Xueting; Singh, Rohit; Foust, Benjamin J.; Hsiao, Chia-Hung Christine; Wiemer, David F.; Wiemer, Andrew J.

Stepping forward in antibody-drug conjugate development 推进抗体-药物偶联物的开发

PHARMACOLOGY & THERAPEUTICS

IF12.5

2022-01-01

110

OAAI

Jin, Yiming; Schladetsch, Megan A.; Huang, Xueting; Balunas, Marcy J.; Wiemer, Andrew J.

Synthesis and Metabolism of BTN3A1 Ligands: Studies on Modifications of the Allylic Alcohol

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2020-12-04

OAAI

Lentini, Nicholas A.; Schroeder, Chloe M.; Harmon, Nyema M.; Huang, Xueting; Schladetsch, Megan A.; Foust, Benjamin J.; Poe, Michael M.; Hsiao, Chia-Hung Christine; Wiemer, Andrew J.; Wiemer, David F.

研究方向