Andrew G. Leach - Publications, H-index & Citations

Andrew G. Leach

The University of Manchester

43H指数

187论文数

7.0K被引数

收录论文 69

发表时间

The Boroxine–Boronic Acid Equilibrium 硼杂环三聚体–硼酸平衡

Journal of the American Chemical Society

IF15.6

2025-10-13

PREAI

Chen Li; Lia Sotorrios; Patrick J. Boaler; Valentas Olikauskas; Matteo Amico; Andrés García-Domínguez; Andrew G. Leach; Guy C. Lloyd-Jones

Design and synthesis of a chemically diverse; lead-like DNA-encoded library from sequential amide coupling 化学多样性先导样DNA编码库的逐级酰胺偶联设计与合成

RSC Med. Chem.

IF3.6

2025-08-22

OAAI

Cameron E. Taylor; Grace Roper; Rhianna Young; Fredrik Svensson; Andreas Brunschweiger; Sam Butterworth; Andrew G. Leach; Michael J. Waring

Dynamic self-assembled meso-structures formed across a wide concentration range in aqueous solutions of propranolol hydrochloride (vol 683, pg 1135,2025)动态自组装中尺度结构在广浓度范围内形成于盐酸普萘洛尔水溶液中（vol 683, pg 1135,2025）

JOURNAL OF COLLOID AND INTERFACE SCIENCE

IF9.7

2025-05-01

OAAI

Yan, Yixuan; Shen, Yichun; Mahmoudi, Najet; Lic, Peixun; Tellam, James; Campbell, Richard A.; Barlow, David J.; Edkins, Katharina; Leach, Andrew G.; Lawrence, M. Jayne

Photoswitchable Azobispyrazole Crystals Achieving Near-Quantitative Crystalline-State Bidirectional E ⇆ Z Conversions

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2024-10-14

PREAI

He, Yixin; Dang, Tongtong; Leach, Andrew G.; Zhang, Zhao-Yang; Li, Tao

Accessing Rare α-Heterocyclic Aziridines via Brønsted Acid-catalyzed Michael Addition/Annulation: Scope, Limitations, and Mechanism

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2024-02-28

OAAI

Hilton, Timothy A.; Leach, Andrew G.; McKay, Aidan P.; Watson, Allan J. B.

Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium

CELL DEATH DISCOVERY

IF7

2023-12-22

OAAI

Seoane, Paula I.; Beswick, James A.; Leach, Andrew G.; Swanton, Tessa; Morris, Lucy V.; Couper, Kevin; Lowe, Martin; Freeman, Sally; Brough, David

In Situ Studies of Arylboronic Acids/Esters and R3SiCF3 Reagents: Kinetics, Speciation, and Dysfunction at the Carbanion-Ate Interface

ACCOUNTS OF CHEMICAL RESEARCH

IF17.7

2022-04-18

OAAI

Garcia-Dominguez, Andres; Leach, Andrew G.; Lloyd-Jones, Guy C.

Data-Driven Derivation of Molecular Substructures That EnhanceDrug Activity in Gram-Negative Bacteria

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-04-15

OAAI

Gurvic, Dominik; Leach, Andrew G.; Zachariae, Ulrich

Asymmetric Synthesis of Heterocyclic Chloroamines and Aziridines by Enantioselective Protonation of Catalytically Generated Enamines**

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2022-02-23

OAAI

McLean, Liam A.; Ashford, Matthew W.; Fyfe, James W. B.; Slawin, Alexandra M. Z.; Leach, Andrew G.; Watson, Allan J. B.

A Lewis Base Nucleofugality Parameter, NF B, and Its Application in an Analysis of MIDA-Boronate Hydrolysis Kinetics

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2021-12-20

OAAI

Taylor, Nicholas P.; Gonzalez, Jorge A.; Nichol, Gary S.; Garcia-Dominguez, Andres; Leach, Andrew G.; Lloyd-Jones, Guy C.

Heavy-Atom Kinetic Isotope Effects: Primary Interest or Zero Point?

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2021-12-06

OAAI

Dale, Harvey J. A.; Leach, Andrew G.; Lloyd-Jones, Guy C.

Protodeboronation of (Hetero)Arylboronic Esters: Direct versus Prehydrolytic Pathways and Self-/Auto-Catalysis

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2021-08-30

OAAI

Hayes, Hannah L. D.; Wei, Ran; Assante, Michele; Geogheghan, Katherine J.; Jin, Na; Tomasi, Simone; Noonan, Gary; Leach, Andrew G.; Lloyd-Jones, Guy C.

Mapping Ligand-Shape Space for Protein-Ligand Systems: Distinguishing Key-in-Lock and Hand-in-Glove Proteins

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2021-03-23

OAAI

Zarnecka, Joanna; Lukac, Iva; Messham, Stephen J.; Hussin, Alhusein; Coppola, Francesco; Enoch, Steven J.; Dossetter, Alexander G.; Griffen, Edward J.; Leach, Andrew G.

Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles

ADVANCED SCIENCE

IF14.1

2021-03-15

OAAI

Islam, Yamir; Leach, Andrew G.; Smith, Jayden; Pluchino, Stefano; Coxon, Christopher R.; Sivakumaran, Muttuswamy; Downing, James; Fatokun, Amos A.; Teixido, Meritxell; Ehtezazi, Touraj

The Inclusion of a Matrix Metalloproteinase-9 Responsive Sequence in Self-assembled Peptide-based Brain-Targeting Nanoparticles Improves the Efficiency of Nanoparticles Crossing the Blood-Brain Barrier at Elevated MMP-9 Levels

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2021-03-01

OAAI

Islam, Yamir; Ehtezazi, Parinaz; Cashmore, Andrew; Marinsalda, Elena; Leach, Andrew G.; Coxon, Christopher R.; Fatokun, Amos A.; Sexton, Darren W.; Khan, Iftikhar; Zouganelis, Georgios; Downing, James; Pluchino, Stefano; Sivakumaran, Muttuswamy; Teixido, Meritxell; Ehtezazi, Touraj

Trialkylammonium salt degradation: implications for methylation and cross-coupling

CHEMICAL SCIENCE

IF7.4

2021-01-01

OAAI

Washington, Jack B.; Assante, Michele; Yan, Chunhui; McKinney, David; Juba, Vanessa; Leach, Andrew G.; Baillie, Sharon E.; Reid, Marc

Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity

RSC CHEMICAL BIOLOGY

IF3.1

2021-01-01

OAAI

Cundy, Nicholas J.; Hare, Roseanna K.; Tang, Tina; Leach, Andrew G.; Jowitt, Thomas A.; Qureshi, Omar; Gordon, John; Barnes, Nicholas M.; Brady, Catherine A.; Raven, Emma L.; Grainger, Richard S.; Butterworth, Sam

Development of Brain Targeting Peptide Based MMP-9 Inhibiting Nanoparticles for the Treatment of Brain Diseases with Elevated MMP-9 Activity

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2020-10-01

OAAI

Islam, Yamir; Khalid, Aneesa; Pluchino, Stefano; Sivakumaran, Muttuswamy; Teixido, Meritxell; Leach, Andrew; Fatokun, Amos A.; Downing, James; Coxon, Christopher; Ehtezazi, Touraj

Catalytic Enantioselective Synthesis of Heterocyclic Vicinal Fluoroamines by Using Asymmetric Protonation: Method Development and Mechanistic Study

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2020-08-18

OAAI

Ashford, Matthew W.; Xu, Chao; Molloy, John J.; Carpenter-Warren, Cameron; Slawin, Alexandra M. Z.; Leach, Andrew G.; Watson, Allan J. B.

Difluorocarbene Generation from TMSCF3: Kinetics and Mechanism of Nal-Mediated and Si-Induced Anionic Chain Reactions 从TMSCF3产生二氟碳烯: Nal介导和Si诱导的阴离子链反应的动力学和机理

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2020-07-27

OAAI

Garcia-Dominguez, Andres; West, Thomas H.; Primozic, Johann J.; Grant, Katie M.; Johnston, Craig P.; Cumming, Grant G.; Leach, Andrew G.; Lloyd-Jones, Guy C.

研究方向