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M

Mike Schutkowski

johannes gutenberg university of mainz

46H指数
197论文数
7.5K被引数
收录论文 76
发表时间
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Identification of dual-targeting PROTACs for ataxia telangiectasia and RAD3-related and aurora kinase A as chemo-sensitizers for leukemia cells鉴定靶向共济失调性毛细血管扩张症和RAD3相关蛋白及Aurora激酶A的双靶点PROTACs作为白血病细胞的化学增敏剂
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-07-01
err0
PREAI
errAlfayomy, Abdallah M.; Neuroth, Sarah; Sarnow, Anne-Christin; Handke, Lukas; Robaa, Dina; Erdmann, Frank; Decroos, Christophe; Schmidt, Matthias; Romier, Chris; Schutkowski, Mike; Kramer, Oliver H.; Sippl, Wolfgang
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Macrophage-Centric Phenotypic Screening Identifies Tetrazolone-Based HDAC6 Inhibitors That Reprogram the Tumor Immune Microenvironment and Improve Immune Checkpoint Blockade巨噬细胞中心表型筛选鉴定出能重编程肿瘤免疫微环境并改善免疫检查点阻断的tetrazolone类HDAC6抑制剂
errJournal of Medicinal Chemistry
IF6.8
err2026-05-29
err0
errOAAI
errNithya Gajendran; Manasa Suresh; Sebastian J. Marquez R.; Sruthi Mohan; Tim Ponsot; David Quiceno-Torres; Mario A. Noboa; Bryan T. Weselman; Xintang Li; Marie Durr; Zora Novakova; Mike Schutkowski; Matias Hepp; Satish Noonepalle; Cyril Barinka; Duncan J. Wardrop; Alejandro Villagra
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err收藏
Beyond formic acid: Peptides in carpenter ant venoms aid in disease protection超越甲酸：切叶蚁蜂毒中的肽有助于疾病防护
errScience Advances
IF12.5
err2026-05-13
err0
errOAAI
errLukas Koch; Sandro Andreotti; Mario Schubert; Elisa Liebhart; Anton M. Zürbig; Julian Gatzki; Benjamin-Florian Hempel; Lydia Kollhoff; Barbara Feldmeyer; Martin Herzberg; Valerie I. C. Rebhahn; Nwet Nwet Win; Adria C. LeBoeuf; Marat Meleshin; Fabian Herrmann; Christian Schwieger; Heike Brötz-Oesterhelt; Andrea Sinz; Mike Schutkowski; Timo H. J. Niedermeyer; Simon Tragust
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err收藏
Selective targeting of cortactin tandem repeat acetylation by human lysine deacetylases人赖氨酸脱乙酰酶对皮质动蛋白串联重复序列乙酰化的选择性靶向
errthe febs journal
IF0
err2026-02-04
err0
errOAAI
errJan Komarek; Miroslava Vosahlikova; Zsofia Kutil; Zora Novakova; Julia Kudlacova; Ruzena Tuckova; Marat Meleshin; Barbora Havlinova; Pavlina Jaklova; Jana Ptackova; Cordelia Schiene-Fischer; Mike Schutkowski; Cyril Barinka
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Capsaicin-Inspired Hydroxamate Hybrids as Selective HDAC6 Inhibitors with Antiproliferative Activity in Hematological Malignancies辣椒素激发的异羟肟酸酯杂合体作为选择性HDAC6抑制剂，在血液系统恶性肿瘤中具有抗增殖活性
errACS Omega
IF4.3
err2026-01-28
err0
errOAAI
errLara Gimenez Borges; Thais Nascimento de Oliveira Alves; Sandra Valeria Vassiliades; Jorge Antonio Elias Godoy Carlos; Karoline de Barros Waitman; Sebastian Hilscher; Mike Schutkowski; Wolfgang Sippl; Maurício Temotheo Tavares; Monica Franco Zannini Junqueira Toledo; Letícia Veras Costa-Lotufo; Thales Kronenberger; João Agostinho Machado-Neto; Roberto Parise-Filho
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Total Synthesis and Structural Revision of Keenamide A
errJOURNAL OF NATURAL PRODUCTS
IF3.6
err2026-01-01
err0
PREAI
errKoch, Lukas; Wiedemann, Christoph; Parthier, Christoph; Seidel, Rudiger W.; Stubbs, Milton T.; Schutkowski, Mike; Meleshin, Marat
err分享
err收藏
From Pharmacophore to Warhead: NAD+-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors从药效团到Warhead：靶向NAD+的三唑类作为机制性SirTuin抑制剂
errAngewandte Chemie International Edition
IF16.9
err2025-10-30
err0
errOAAI
errFlorian Friedrich; Dr. Marat Meleshin; Niklas Papenkordt; Lena Gaitzsch; Isabel Prucker; Dr. Marco Borso; Jan Ruprecht; Christopher Vorreiter; Sabrina Rast; Prof. Lin Zhang; Prof. Matthias Schiedel; Prof. Wolfgang Sippl; Prof. Axel Imhof; Prof. Henning J. Jessen; Prof. Oliver Einsle; Prof. Mike Schutkowski; Prof. Manfred Jung
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Substrate-Guided Development of HDAC11-Selective Inhibitors Featuring α-Amino Amide Zinc-Binding Groups基于底物引导的HDAC11选择性抑制剂开发：具有α-氨基酰胺锌结合基团
errACS Omega
IF4.3
err2025-10-13
err0
errOAAI
errSebastian Hilscher; Marat Meleshin; Fady Baselious; Cyril Barinka; Wolfgang Sippl; Mike Schutkowski; Cordelia Schiene-Fischer
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err收藏
Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment多娜·弗洛尔与她的两个丈夫：用于髓系癌症治疗的HDAC6/AKT2新型抑制剂的发现
errComputers in Biology and Medicine
IF6.3
err2025-08-28
err0
PREAI
errKaroline B. Waitman; Holli-Joi Martin; Jorge A.E.G. Carlos; Rodolpho C. Braga; Vinícius A.M. Souza; Cleber C. Melo-Filho; Sebastian Hilscher; Mônica F.Z. J. Toledo; Maurício T. Tavares; Letícia V. Costa-Lotufo; João A. Machado-Neto; Mike Schutkowski; Wolfgang Sippl; Thales Kronenberger; Vinicius M. Alves; Roberto Parise-Filho; Eugene N. Muratov
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In silico screening of a designed focused chemical space identifies novel alkyl hydrazides as potent HDAC11 inhibitors基于计算机的筛选针对一个设计的聚焦化学空间，鉴定出新型烷基肼类化合物作为强效HDAC11抑制剂
errComputers in Biology and Medicine
IF6.3
err2025-07-04
err0
errOAAI
errFady Baselious; Sebastian Hilscher; Lukas Handke; Cyril Barinka; Mike Schutkowski; Wolfgang Sippl
err分享
err收藏
The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells: PHARMACOLOGY蛋白去乙酰化酶HDAC10调控恶性淋巴细胞的DNA复制：药理学
errLEUKEMIA
IF13.4
err2025-04-29
err0
errOAAI
errMieland, Andreas O.; Petrosino, Giuseppe; Dejung, Mario; Chen, Jia-Xuan; Fulzele, Amitkumar; Mahmoudi, Fereshteh; Tu, Jia-Wey; Mustafa, Al-Hassan M.; Zeyn, Yanira; Hieber, Christoph; Bros, Matthias; Schnoeder, Tina M.; Heidel, Florian H.; Najafi, Sara; Oehme, Ina; Hofmann, Ilse; Schutkowski, Mike; Hilscher, Sebastian; Kosan, Christian; Butter, Falk; Kraemer, Oliver H.
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err收藏
Development of potent and selective tetrahydro-β-carboline-based HDAC6 inhibitors with promising activity against triple-negative breast cancer开发具有抗三阴性乳腺癌潜力的强效且选择性的四氢-β-咔啉基HDAC6抑制剂
errRSC MEDICINAL CHEMISTRY
IF3.6
err2025-01-01
err0
PREAI
errFathy, Aya; Allam, Amro; Elhady, Ahmed K.; El-Gamil, Dalia S.; Lin, Kai-Chun; Chang, Yen-Hua; Lee, Yu-Hsuan; Hilscher, Sebastian; Schutkowski, Mike; Ibrahim, Hany S.; Chen, Shun-Hua; Chen, Chun-Hong; Abadi, Ashraf H.; Cheng, Yi-Sheng
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err收藏
Epigenetic-based differentiation therapy for Acute Myeloid Leukemia
errNATURE COMMUNICATIONS
IF15.7
err2024-07-02
err2
errOAAI
errSan Jose-Eneriz, Edurne; Gimenez-Camino, Naroa; Rabal, Obdulia; Garate, Leire; Miranda, Estibaliz; Gomez-Echarte, Nahia; Garcia, Fernando; Charalampopoulou, Stella; Saez, Elena; Vilas-Zornoza, Amaia; San Martin-Uriz, Patxi; Valcarcel, Luis V.; Barrena, Naroa; Alignani, Diego; Tamariz-Amador, Luis Esteban; Perez-Ruiz, Ana; Hilscher, Sebastian; Schutkowski, Mike; Alfonso-Pierola, Ana; Martinez-Calle, Nicolas; Larrayoz, Maria Jose; Paiva, Bruno; Calasanz, Maria Jose; Munoz, Javier; Isasa, Marta; Martin-Subero, Jose Ignacio; Pineda-Lucena, Antonio; Oyarzabal, Julen; Agirre, Xabier; Prosper, Felipe
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err收藏
Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells
errJOURNAL OF ADVANCED RESEARCH
IF13
err2024-06-01
err2
errOAAI
errFischer, Marten A.; Mustafa, Al-Hassan M.; Hausmann, Kristin; Ashry, Ramy; Kansy, Anita G.; Liebl, Magdalena C.; Brachetti, Christina; Piee-Staffa, Andrea; Zessin, Matthes; Ibrahim, Hany S.; Hofmann, Thomas G.; Schutkowski, Mike; Sippl, Wolfgang; Kraemer, Oliver H.
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err收藏
Key structural requirements of benzamide derivatives for histone deacetylase inhibition: design, synthesis and biological evaluation抑制组蛋白去乙酰化酶的苯甲酰胺衍生物的关键结构要求: 设计，合成和生物学评估
errFUTURE MEDICINAL CHEMISTRY
IF3.4
err2024-04-16
err1
PREAI
errCheshmazar, Narges; Hamzeh-Mivehroud, Maryam; Hemmati, Salar; Abolhasani, Hoda; Heidari, Fatemeh; Charoudeh, Hojjatollah Nozad; Zessin, Matthes; Schutkowski, Mike; Sippl, Wolfgang; Dastmalchi, Siavoush
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err收藏
1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors1，3-二苯基脲基异羟肟酸酯作为产生有效的抗疟组蛋白去乙酰化酶抑制剂的有希望的支架
errSCIENTIFIC REPORTS
IF3.9
err2023-11-29
err1
errOAAI
errTavares, Mauricio T.; Krueger, Arne; Yan, Sun L. Rei; Waitman, Karoline B.; Gomes, Vinicius M.; de Oliveira, Daffiny Sumam; Paz, Franciarli; Hilscher, Sebastian; Schutkowski, Mike; Sippl, Wolfgang; Ruiz, Claudia; Toledo, Monica F. Z. J.; Hassimotto, Neuza M. A.; Machado-Neto, Joo A.; Poso, Antti; Cameron, Michael D.; Bannister, Thomas D.; Palmisano, Giuseppe; Wrenger, Carsten; Kronenberger, Thales; Parise-Filho, Roberto
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err收藏
Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-10-30
err9
errOAAI
errSinatra, Laura; Vogelmann, Anja; Friedrich, Florian; Tararina, Margarita A.; Neuwirt, Emilia; Colcerasa, Arianna; Koenig, Philipp; Toy, Lara; Yesiloglu, Talha Z.; Hilscher, Sebastian; Gaitzsch, Lena; Papenkordt, Niklas; Zhai, Shiyang; Zhang, Lin; Romier, Christophe; Einsle, Oliver; Sippl, Wolfgang; Schutkowski, Mike; Gross, Olaf; Bendas, Gerd; Christianson, David W.; Hansen, Finn K.; Jung, Manfred; Schiedel, Matthias
err分享
err收藏
Application of Ligand- and Structure-Based Prediction Models for the Design of Alkylhydrazide-Based HDAC3 Inhibitors as Novel Anti-Cancer Compounds基于配体和结构的预测模型在烷基酰肼类HDAC3抑制剂设计中的应用
errPHARMACEUTICALS
IF4.8
err2023-07-06
err5
errOAAI
errBuelbuel, Emre F. F.; Robaa, Dina; Sun, Ping; Mahmoudi, Fereshteh; Melesina, Jelena; Zessin, Matthes; Schutkowski, Mike; Sippl, Wolfgang
err分享
err收藏
Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6)
errACS CHEMICAL BIOLOGY
IF3.8
err2023-07-03
err10
errOAAI
errMotlova, Lucia; Snajdr, Ivan; Kutil, Zsofia; Andris, Erik; Ptacek, Jakub; Novotna, Adela; Novakova, Zora; Havlinova, Barbora; Tueckmantel, Werner; Draberova, Helena; Majer, Pavel; Schutkowski, Mike; Kozikowski, Alan; Rulisek, Lubomir; Barinka, Cyril
err分享
err收藏
Synthesis of Complex Thiazoline-Containing Peptides by Cyclodesulfhydration of N-Thioacyl-2-Mercaptoethylamine Derivatives
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2023-05-11
err2
errOAAI
errMeleshin, Marat; Koch, Lukas; Wiedemann, Christoph; Schutkowski, Mike
err分享
err收藏

研究方向

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