Frédéric H.‐T. Allain - Publications, H-index & Citations

Frédéric H.‐T. Allain

eth zürich

75H指数

301论文数

1.9W被引数

收录论文 130

发表时间

A Comprehensive 19F NMR Framework for Fragment-Based Drug Discovery: The Validated Screening Library OpenFL600 and Efficient Affinity Ranking by CSAR 基于片段的药物发现中19F核磁共振的全面框架：验证的筛选库OpenFL600及CSAR高效亲和力排名

Angewandte Chemie-International Edition

IF16.9

2026-07-27

OAAI

Simon H. Rüdisser; Gabriela Stadler; Giacomo Padroni; Daria Barbash; Marco M. Ruckstuhl; Nils Lorz; Christina Jordan; Sarah Skibinski; Timo T. Stühlinger; Sarah E. Kratzwald; Katharina M. Siess; Sven Brüschweiler; Gerald Platzer; Antoine Cléry; Robert Konrat; Frédéric H.-.T. Allain; Alvar D. Gossert

Structural and mechanistic insights into primer synthesis initiation by DNA primase DNA引物酶引发引物合成的结构与机制研究

Nature Communications

IF15.7

2026-07-03

OAAI

Pengzhi Wu; Fred F. Damberger; Johannes Zehnder; Nina Wehr; Niklas Senning; Georg Lipps; Thomas Wiegand; Frédéric H.-T. Allain

Newton’s cradle-like allosteric mechanism explains regulatory RsmE RNA binding 牛顿摆式别构机制解释了调控性RsmE RNA的结合

Nature Communications

IF15.7

2026-04-22

OAAI

Esteban Finol; Fred F. Damberger; Miroslav Krepl; Timo Flügel; Priscilla Dietrich; Thomas C. T. Michaels; Beat Vögeli; Jiří Šponer; Frédéric H-T. Allain

Multiplexed Analysis of Multicomponent Biomolecular Condensates without Any Tag 无标签的多组分生物分子凝聚体的多重分析

Journal of the American Chemical Society

IF15.6

2025-12-08

OAAI

Gyula Pálfy; Johannes Schmoll; Maria E. Pérez; Fred F. Damberger; Yaning Han; Leonidas Emmanouilidis; Frédéric H.-T. Allain; Mihajlo Novakovic

Water-detected NMR allows dynamic observations of repeat-expansion RNA condensates 水检测核磁共振（Water-detected NMR）允许对重复扩展RNA凝聚体进行动态观察。

Nature Chemistry

IF20.2

2025-10-15

OAAI

Johannes Schmoll; Mihajlo Novakovic; Frédéric H-.T. Allain

High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation 对100 000个小分子进行高通量筛选，在C9ORF72 ALS神经元中鉴定出可促使G4C2重复RNA进入核输出并引发与重复相关的非规范翻译的剪接体调节剂。

NUCLEIC ACIDS RESEARCH

IF13.1

2025-04-10

PREAI

Luteijn, Maartje J.; Bhaskar, Varun; Trojer, Dominic; Schuerz, Melanie; Mahboubi, Hicham; Handl, Cornelia; Pizzato, Nicolas; Pfeifer, Martin; Dafinca, Ruxandra; Voshol, Hans; Giorgetti, Elisa; Manneville, Carole; Garnier, Isabelle P. M.; Mueller, Matthias; Zeng, Fanning; Buntin, Kathrin; Markwalder, Roger; Schroeder, Harald; Weiler, Jan; Khar, Dora; Schuhmann, Tim; Groot-Kormelink, Paul J.; Keller, Caroline Gubser; Farmer, Pierre; MacKay, Angela; Beibel, Martin; Roma, Guglielmo; D'Ario, Giovanni; Merkl, Claudia; Schebesta, Michael; Hild, Marc; Elwood, Fiona; Vahsen, Bjoern F.; Ripin, Nina; Clery, Antoine; Allain, Frederic; Labow, Mark; Gabriel, Daniela; Chao, Jeffrey A.; Talbot, Kevin; Nash, Mark; Hunziker, Juerg; Meisner-Kober, Nicole C.

Steering research on mRNA splicing in cancer towards clinical translation 癌症中mRNA剪接的研究转向临床翻译

NATURE REVIEWS CANCER

IF66.8

2024-10-09

PREAI

Anczukow, Olga; Allain, Frederic H. -T.; Angarola, Brittany L.; Black, Douglas L.; Brooks, Angela N.; Cheng, Chonghui; Conesa, Ana; Crosse, Edie I.; Eyras, Eduardo; Guccione, Ernesto; Lu, Sydney X.; Neugebauer, Karla M.; Sehgal, Priyanka; Song, Xiao; Tothova, Zuzana; Valcarcel, Juan; Weeks, Kevin M.; Yeo, Gene W.; Thomas-Tikhonenko, Andrei

The molecular dissection of TRIM25's RNA-binding mechanism provides key insights into its antiviral activity TRIM25的RNA结合机制的分子解剖提供了其抗病毒活性的关键见解

NATURE COMMUNICATIONS

IF15.7

2024-10-01

OAAI

Alvarez, Lucia; Haubrich, Kevin; Iselin, Louisa; Gillioz, Laurent; Ruscica, Vincenzo; Lapouge, Karine; Augsten, Sandra; Huppertz, Ina; Choudhury, Nila Roy; Simon, Bernd; Masiewicz, Pawel; Lethier, Mathilde; Cusack, Stephen; Rittinger, Katrin; Gabel, Frank; Leitner, Alexander; Michlewski, Gracjan; Hentze, Matthias W.; Allain, Frederic H. T.; Castello, Alfredo; Hennig, Janosch

N-terminal domain of polypyrimidine-tract binding protein is a dynamic folding platform for adaptive RNA recognition

NUCLEIC ACIDS RESEARCH

IF13.1

2024-08-24

OAAI

Damberger, Fred F.; Krepl, Miroslav; Arora, Rajika; Beusch, Irene; Maris, Christophe; Dorn, Georg; Sponer, Jiri; Ravindranathan, Sapna; Allain, Frederic H-T

Buffer choice and pH strongly influence phase separation of SARS-CoV-2 nucleocapsid with RNA

MOLECULAR BIOLOGY OF THE CELL

IF2.7

2024-05-01

OAAI

Kathe, Nina C.; Novakovic, Mihajlo; Allain, Frederic H. -T.

The diversity of splicing modifiers acting on A-1 bulged 5′-splice sites reveals rules for rational drug design

NUCLEIC ACIDS RESEARCH

IF13.1

2024-03-30

OAAI

Malard, Florian; Wolter, Antje C.; Marquevielle, Julien; Morvan, Estelle; Ecoutin, Agathe; Rudisser, Simon H.; Allain, Frederic H. T.; Campagne, Sebastien

Initial Primer Synthesis of a DNA Primase Monitored by Real-Time NMR Spectroscopy

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2024-03-27

OAAI

Wu, Pengzhi; Zehnder, Johannes; Schroder, Nina; Blummel, Pascal E. W.; Salmon, Loic; Damberger, Fred. F.; Lipps, Georg; Allain, Frederic H. -T.; Wiegand, Thomas

A solid beta-sheet structure is formed at the surface of FUS droplets during aging 在老化过程中，在FUS液滴的表面形成固体 β-片层结构

NATURE CHEMICAL BIOLOGY

IF13.7

2024-03-11

OAAI

Emmanouilidis, Leonidas; Bartalucci, Ettore; Kan, Yelena; Ijavi, Mahdiye; Perez, Maria Escura; Afanasyev, Pavel; Boehringer, Daniel; Zehnder, Johannes; Parekh, Sapun H.; Bonn, Mischa; Michaels, Thomas C. T.; Wiegand, Thomas; Allain, Frederic H. -T.

Specific protein-RNA interactions are mostly preserved in biomolecular condensates

SCIENCE ADVANCES

IF12.5

2024-03-08

OAAI

de Vries, Tebbe; Novakovic, Mihajlo; Ni, Yinan; Smok, Izabela; Inghelram, Clara; Bikaki, Maria; Sarnowski, Chris P.; Han, Yaning; Emmanouilidis, Leonidas; Padroni, Giacomo; Leitner, Alexander; Allain, Frederic H. -T.

Ensemble structure of the N-terminal domain (1-267) of FUS in a biomolecular condensate

BIOPHYSICAL JOURNAL

IF3.1

2024-03-01

OAAI

Esteban-Hofer, Laura; Emmanouilidis, Leonidas; Yulikov, Maxim; Allain, Frederic H. -T.; Jeschke, Gunnar

Integrative solution structure of PTBP1-IRES complex reveals strong compaction and ordering with residual conformational flexibility PTBP1-IRES复合体的整体溶液结构显示出强压实和有序的残余构象柔性

NATURE COMMUNICATIONS

IF15.7

2023-10-13

OAAI

Dorn, Georg; Gmeiner, Christoph; de Vries, Tebbe; Dedic, Emil; Novakovic, Mihajlo; Damberger, Fred F.; Maris, Christophe; Finol, Esteban; Sarnowski, Chris P.; Kohlbrecher, Joachim; Welsh, Timothy J.; Bolisetty, Sreenath; Mezzenga, Raffaele; Aebersold, Ruedi; Leitner, Alexander; Yulikov, Maxim; Jeschke, Gunnar; Allain, Frederic H. -T.

Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39

NATURE COMMUNICATIONS

IF15.7

2023-09-04

OAAI

Campagne, Sebastien; Jutzi, Daniel; Malard, Florian; Matoga, Maja; Romane, Ksenija; Feldmuller, Miki; Colombo, Martino; Ruepp, Marc-David; Allain, Frederic H-T.

Loss of TDP-43 oligomerization or RNA binding elicits distinct aggregation patterns

EMBO JOURNAL

IF8.3

2023-07-11

OAAI

Perez-Berlanga, Manuela; Wiersma, Vera, I; Zbinden, Aurelie; De Vos, Laura; Wagner, Ulrich; Foglieni, Chiara; Mallona, Izaskun; Betz, Katharina M.; Clery, Antoine; Weber, Julien; Guo, Zhongning; Rigort, Ruben; de Rossi, Pierre; Manglunia, Ruchi; Tantardini, Elena; Sahadevan, Sonu; Stach, Oliver; Hruska-Plochan, Marian; Allain, Frederic H-T; Paganetti, Paolo; Polymenidou, Magdalini

Elongated Bacterial Pili as a Versatile Alignment Medium for NMR Spectroscopy

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2023-06-27

OAAI

Nouri, Sirine; Boudet, Julien; Dreher-Teo, Hiang; Allain, Frederic H. -T.; Glockshuber, Rudi; Salmon, Loic; Giese, Christoph

RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription

SCIENCE ADVANCES

IF12.5

2023-04-21

OAAI

Blatter, Markus; Meylan, Charlotte; Clery, Antoine; Giambruno, Roberto; Nikolaev, Yaroslav; Heidecker, Michel; Solanki, Jessica Arvindbhai; Diaz, Manuel O.; Gabellini, Davide; Allain, Frederic H. -T.

研究方向