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Takao Yamaguchi

the university of osaka

34H指数
747论文数
5.0K被引数
收录论文 67
发表时间
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An improved guanidine protecting group for the efficient synthesis of GuNA[t-Bu]-modified antisense oligonucleotides一种用于高效合成GuaNA[t-Bu]-修饰的反义寡核苷酸的改进胍基保护基
errorg. biomol. chem.
IF0
err2026-06-23
err0
PREAI
errAjaya Ram Shrestha; Junsuke Hayashi; Ryohei Kajino; Ryusuke Hatanaka; Naohiro Horie; Takao Yamaguchi; Satoshi Obika; Tadashi Umemoto
err分享
err收藏
Lipschitz homotopy convergence of Alexandrov spaces II亚历山德罗夫空间的利普希茨同伦收敛 II
errJournal of Topology and Analysis
IF0.4
err2026-02-01
err0
PREAI
errFujioka, Tadashi; Mitsuishi, Ayato; Yamaguchi, Takao
err分享
err收藏
Genetic Encoding of a Trifunctional Photo-Cross-Linker with a Cleavable Alkyl Ester Moiety含可裂解烷基酯基团的三功能光交联剂的可遗传编码
errChemBioChem
IF2.8
err2026-01-30
err0
errOAAI
errMasahiro Takayama; Tomoya Tsubota; Takao Yamaguchi; Kosuke Chiba; Takumi Yoshida; Yoshiyuki Hari; Yu-Shi Tian; Daisuke Takaya; Asuka Mori; Tomohito Tsukamoto; Kenji Ishimoto; Yukio Ago; Yoshiaki Okada; Kensaku Sakamoto; Takefumi Doi; Kaori Fukuzawa; Satoshi Obika; Shinsaku Nakagawa; Nobumasa Hino
err分享
err收藏
Sequence-dependent RNA cleavage by the 8–17 DNAzyme: Identification of preferred tetranucleotide motifs8–17 DNAzyme的序列依赖性RNA切割：优先四核苷酸基序的鉴定
errBioorganic & Medicinal Chemistry
IF3
err2025-12-14
err0
PREAI
errSatoko Nakajima; Shuhei Miyakawa; Shu Ohno; Haruki Ikemoto; Rikuto Maruyama; Kosuke Chiba; Ryota Suginaka; Chihiro Oda; Yuuya Kasahara; Kaori Fukuzawa; Satoshi Obika; Takao Yamaguchi
err分享
err收藏
Current Trends in Liquid Chromatography-Mass Spectrometry Analysis of Small Interfering RNAs: A Short Review液相色谱-质谱法分析小干扰RNA的当前趋势：一篇简短综述
errJournal of Chromatography A
IF4
err2025-11-17
err0
errOAAI
errHiroyuki Togawa; Takao Yamaguchi; Junji Kawakami; Satoshi Obika
err分享
err收藏
Theoretical calculation of the amounts of nucleotide deletion impurities in oligonucleotides寡核苷酸中核苷酸缺失杂质的量理论计算
errInternational Journal of Pharmaceutics
IF5.2
err2025-11-08
err0
errOAAI
errYasunori Uchida; Tokuyuki Yoshida; Emi Saito; Hirokazu Nankai; Kaoru Karasawa; Chie Inagaki; Noriyuki Iwasaki; Daisuke Higo; Kentaro Takahara; Takashi Osawa; Takao Yamaguchi; Kosuke Ito; Junji Kawakami; Satoshi Obika; Takao Inoue
err分享
err收藏
Development of Synthetic Routes to 2′-O,4′-C-Spirocyclopentylene-Bridged Nucleic Acids: Thymidine, Guanosine, and Adenosine2′-O,4′-C-螺环戊烯基桥联核苷酸的合成路线开发：胸苷、鸟苷和腺苷
errChemistry – A European Journal
IF3.7
err2025-11-07
err0
errOAAI
errRiku Kumagai; Riko Yamada; Prof. Takao Yamaguchi; Prof. Satoshi Obika
err分享
err收藏
Hydrophilic additives enhancing electrospray ionization of oligonucleotides in hexafluoro-2-propanol-free reversed-phase ion-pair liquid chromatography/mass spectrometry亲水性添加剂增强六氟-2-丙醇免反相离子对液相色谱-质谱法中寡核苷酸的电喷雾离子化
errJournal of Chromatography A
IF4
err2025-10-23
err0
PREAI
errTakashi Miyazaki; Natsuyo Asano; Satoshi Yamaki; Takao Yamaguchi; Satoshi Obika
err分享
err收藏
Cycloalkane Incorporation Into the 2′; 4′-Bridge of Locked Nucleic Acid: Enhancing Nuclease Stability; Reducing Phosphorothioate Modifications; and Lowering Hepatotoxicity in Antisense Oligonucleotides将环烷烃引入锁 nucleic acid 的 2′; 4′-桥中：增强 nuclease 稳定性；减少 phosphorothioate 修饰；并降低 antisense oligonucleotides 的肝毒性
errJACS Au
IF8.7
err2025-10-15
err0
errOAAI
errTakao Yamaguchi; Hibiki Komine; Takaya Sugiura; Riku Kumagai; Tokuyuki Yoshida; Kiyomi Sasaki; Taisuke Nakayama; Haruhiko Kamada; Takao Inoue; Satoshi Obika
err分享
err收藏
Development of a Synthetic Lethality-Based Combination Therapy Using LIG1 and PARP Inhibitors for Prostate Cancer基于LIG1和PARP抑制剂的合成致死性联合疗法在前列腺癌中的开发
errCancer Science
IF4.3
err2025-09-16
err0
errOAAI
errMasaru Tani; Koji Hatano; Yu Ishizuya; Toshiki Oka; Tomohiro Kanaki; Shunsuke Inoguchi; Akihiro Yoshimura; Yuki Horibe; Yutong Liu; Sassi Nesrine; Yohei Okuda; Akinaru Yamamoto; Toshihiro Uemura; Gaku Yamamichi; Takuji Hayashi; Yoshiyuki Yamamoto; Taigo Kato; Atsunari Kawashima; Takao Yamaguchi; Satoshi Obika; Kosuke Yusa; Norio Nonomura; Keisuke Nimura
err分享
err收藏
Phthalimide: a potential warhead for switchable and bioorthogonal conjugation邻苯二甲酰亚胺：一种用于可切换和生物正交偶联的潜在弹头
errChem. Commun.
IF4.2
err2025-08-06
err0
PREAI
errKosuke Chiba; Takumi Yoshida; Kana Okada; Minoru Ishikawa †; Yuichi Hashimoto; Satoshi Obika; Takao Yamaguchi
err分享
err收藏
Separation of deaminated impurities from the desired oligonucleotides using supercritical fluid chromatography
errJOURNAL OF CHROMATOGRAPHY A
IF4
err2025-03-01
err0
errOAAI
errHayashida, Momoka; Suzuki, Risa; Horie, Shinnosuke; Masuda, Junichi; Yamaguchi, Takao; Obika, Satoshi
err分享
err收藏
Separation and Characterization of Therapeutic Oligonucleotide Isomer Impurities by Cyclic Ion Mobility Mass Spectrometry
errJOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
IF2.7
err2024-07-31
err2
errOAAI
errOmuro, Shogo; Yamaguchi, Takao; Kawase, Taiji; Hirose, Kenji; Yoshida, Tokuyuki; Inoue, Takao; Obika, Satoshi
err分享
err收藏
Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine (Mar, 10.1016/j.omtn.2024.102161, 2024)
errMOLECULAR THERAPY NUCLEIC ACIDS
IF6.1
err2024-06-01
err0
errOAAI
errMatsubayashi, Taiki; Yoshioka, Kotaro; Mon, Su Su Lei; Katsuyama, Maho; Jia, Chunyan; Yamaguchi, Takao; Hara, Rintaro Iwata; Nagata, Tetsuya; Nakagawa, Osamu; Obika, Satoshi; Yokota, Takanori
err分享
err收藏
Introduction of sugar-modified nucleotides into CpG-containing antisense oligonucleotides inhibits TLR9 activation将糖修饰的核苷酸引入含CpG的反义寡核苷酸可抑制TLR9的激活
errSCIENTIFIC REPORTS
IF3.9
err2024-05-21
err4
errOAAI
errYoshida, Tokuyuki; Hagihara, Tomoko; Uchida, Yasunori; Horiuchi, Yoshiyuki; Sasaki, Kiyomi; Yamamoto, Takenori; Yamashita, Takuma; Goda, Yukihiro; Saito, Yoshiro; Yamaguchi, Takao; Obika, Satoshi; Yamamoto, Seiji; Inoue, Takao
err分享
err收藏
Separation of the diastereomers of phosphorothioated siRNAs by anion-exchange chromatography under non-denaturing conditions
errJOURNAL OF CHROMATOGRAPHY A
IF4
err2024-04-01
err4
errOAAI
errTogawa, Hiroyuki; Okubo, Takashi; Horiuchi, Kazuki; Yamaguchi, Takao; Tomita-Sudo, Elisa; Akita, Tomoka; Kawakami, Junji; Obika, Satoshi
err分享
err收藏
Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine
errMOLECULAR THERAPY NUCLEIC ACIDS
IF6.1
err2024-03-01
err1
errOAAI
errMatsubayashi, Taiki; Yoshioka, Kotaro; Mon, Su Su Lei; Katsuyama, Maho; Jia, Chunyan; Yamaguchi, Takao; Hara, Rintaro Iwata; Nagata, Tetsuya; Nakagawa, Osamu; Obika, Satoshi; Yokota, Takanori
err分享
err收藏
Applicability of supercritical fluid chromatography for oligonucleotide analysis: A proof-of-concept study超临界流体色谱法在寡核苷酸分析中的适用性: 概念验证研究
errJOURNAL OF CHROMATOGRAPHY A
IF4
err2023-10-01
err6
errOAAI
errHayashida, Momoka; Suzuki, Risa; Horie, Shinnosuke; Masuda, Junichi; Yamaguchi, Takao; Obika, Satoshi
err分享
err收藏
Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N′-methylguanidine-bridged nucleic acids
errNUCLEIC ACIDS RESEARCH
IF13.1
err2023-07-18
err0
errOAAI
errYamaguchi, Takao; Horie, Naohiro; Aoyama, Hiroshi; Kumagai, Shinji; Obika, Satoshi
err分享
err收藏
Synthesis of multivalent fatty acid-conjugated antisense oligonucleotides: Cell internalization, physical properties, and in vitro and in vivo activities
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2023-03-01
err2
errOAAI
errTanaka, Yuya; Tanioku, Yurika; Nakayama, Taisuke; Aso, Kotomi; Yamaguchi, Takao; Kamada, Haruhiko; Obika, Satoshi
err分享
err收藏

研究方向

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合作学者
合作期刊
J
Julian I. Schroeder
H 指数: 132 · 论文数: 465
H
Hiroshi Okamoto
H 指数: 94 · 论文数: 2.2K
S
Shahriar Mobashery
H 指数: 81 · 论文数: 609
T
Takashi Miyata
H 指数: 69 · 论文数: 519
Y
Yuichi Hashimoto
H 指数: 68 · 论文数: 727
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