张艳平 (Yanping Zhang)

tongji university预聘副教授邮箱:yanpingzhang@tongji.edu.cn

H指数:17

被引数:1,611

个人简介

"张艳平，同济大学生命科学与技术学院，预聘副教授，博士生导师。本科及硕士就读于中南大学计算机科学与技术专业，博士就读于德国慕尼黑工业大学生物信息学专业，2017年获得博士学位。2018年受聘于同济大学生命科学与技术学院，主持多个国家级科研项目，包括国家自然科学青年基金、面上项目等，作为骨干参与国家重点研发计划。\n主要研究方向1为细胞命运转变过程中的表观遗传调控机制研究，主要通过整合多组学高通量数据如微量细胞、单细胞表观遗传组学数据系统探究细胞状态转变及命运决定的表观遗传学调控机制，相关研究成果发表在Cell Stem Cell、Cell Research、Stem Cell Reports等权威学术期刊。研究方向2为多组学的深度学习算法开发，基于多组学数据：譬如单细胞转录组学、空间转录组学数据、蛋白质组学数据，开发机器学习算法，系统解决多组学数据整合分析问题，将多组学数据转化为生物学和临床见解，以帮助阐明疾病的分子机制。目前，课题组与同济大学电子与信息工程学院陈广教授课题组有紧密的合作，可以联合培养博士。\n发表论文\n#共同第一作者*共同通讯\n1. C.Xi#; Z.Yan#; D.Bai#; Y. Zhang#; B. Wang#; X. Han#; L.Wu; X. Shi; Z.Hu; M. Tang; Zh. Su; Y. Liu; B.Liu; J.Yin; H.Wang; X.Li*; Y.Zhang*; S. Gao*; W.Liu*; Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy, Protein & Cell, 2024.\n2. H.Li#, J.Sun#, Y.Dong,…, R.Le*, S.Gao*, Y.Zhang*. Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition. Stem cell reports, 2023,18(2), 449–462.\n3.Y.Zhang#, Y. Huang#, Y. Dong, X. Liu, X. Kou, Y. Zhao, A. Zhao, J. Sun, Z. Su, Z. Li, H. Zhang, Y. Li, S. Cao, J. Wei, J. Yin, L. Kang, Y. Gao, J. Chen, Y. Wang, C. Li, R. Gao, H. Wang, S. Gao, and R. Le, Unique Patterns of H3K4me3 and H3K27me3 in 2-Cell-like Embryonic Stem Cells. Stem Cell Reports, 2021.\n4.R.Le#, Y.Huang#, Y. Zhang#, H. Wang#, J. Lin, Y#. Dong, Z. Li, M. Guo, X. Kou, Y. Zhao, M. Chen, Q. Zhu, A. Zhao, J. Yin, J. Sun, Z. Su, K. Shi, Y. Gao, J. Chen, W. Liu, L. Kang, Y. Wang, C. Li, X. Liu, R. Gao, H. Wang, Z. Ju, and S. Gao, Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells. Cell Stem Cell, 2020.\n5.Guo, M. #, Y. Zhang#, J. Zhou, Y. Bi, J. Xu, C. Xu, X. Kou, Y. Zhao, Y. Li, Z. Tu, K. Liu, J. Lin, P. Yang, S. Gao, and Y. Wang, Precise temporal regulation of Dux is important for embryo development. Cell Res, 2019. 29(11): p. 956-959.\n6.Liu, Y.#, Y. Zhang#, J. Yin, Y. Gao, Y. Li, D. Bai, W. He, X. Li, P. Zhang, R. Li, L. Zhang, Y. Jia, Y. Zhang, J. Lin, Y. Zheng, H. Wang, S. Gao, W. Zeng, and W. Liu, Distinct H3K9me3 and DNA methylation modifications during mouse spermatogenesis. J Biol Chem, 2019. 294(49): p. 18714-18725.\n7.Smida, J.#, H. Xu#, Y. Zhang#, D. Baumhoer, S. Ribi, M. Kovac, I. von Luettichau, S. Bielack, V.B. O'Leary, C. Leib-Mosch, D. Frishman, and M. Nathrath, Genome-wide analysis of somatic copy number alterations and chromosomal breakages in osteosarcoma. Int J Cancer, 2017. 141(4): p. 816-828.\n8.Y. Zhang#, H. Xu#, and D. Frishman, Genomic determinants of somatic copy number alterations across human cancers. Hum Mol Genet, 2016. 25(5): p. 1019-30."