未登录 Reevaluating safety pharmacology respiratory studies within the ICH S7A core battery: A multi-company evaluation of preclinical utility and clinical translation 重新评估ICH S7A核心组中的安全性药理学呼吸研究：一项多公司评估，评估其非临床效用和临床转化 Kremer, John J.; Abernathy, Matt M.; Ackley, David; Clark, Matthew; Dasilva, Jamie K.; Foley, Michael C.; Greiter-Wilke, A.; Henderson-Park, Kim H.; Morimoto, Bruce H.; Paglialunga, Sabina; Pugsley, Michael K.; Regan, Chris P.; Rossman, Eric I.; Segretti, Jason A.; Traebert, Martin; Vargas, Hugo M.; Wisialowski, Todd A.; Friedrichs, Greg S. 分享 收藏
Reevaluating safety pharmacology respiratory studies within the ICH S7A core battery: A multi-company evaluation of preclinical utility and clinical translation 重新评估ICH S7A核心电池内的安全药理学呼吸研究: 临床前效用和临床翻译的多公司评估 Friedrichs, G. S.; Abernathy, M. M.; Ackley, D.; Clark, M.; DaSilva, J. K.; Foley, C. M.; Greiter-Wilke, A.; Henderson, K. A.; Kremer, J. J.; Morimoto, B. H.; Paglialunga, S.; Pugsley, M. K.; Regan, C. P.; Rossman, E. I.; Segretti, J. A.; Traebert, M.; Vargas, H. M.; Wisialowski, T. A. 分享 收藏
GLIOBLASTOMA IN 2021, DEVELOPING A LARGE INDIVIDUAL PATIENT DATABASE TO INVESTIGATE OUTCOMES AND TREATMENT PATTERNS Robinson, S. D.; Clark, M.; Rathbone, M.; Black, L.; Kovacs, B.; Augustine, P.; Hatton, R.; Lathangue, H.; Wontumi, S.; Conkey, D.; Rayner, L.; Theodoulou, M.; Kalra, B.; Fullagar, A.; Lachmann, E.; Durage, P. T. T.; Counsell, L.; Pillai, V; Christodoulou, P.; Teoh, M.; Bowman, M.; Williams, A.; Norris, T.; Iqbal, N. S.; Abdelsadig, M.; Kingdon, S.; Yogalingham, K.; Duffy, D.; Lau, S. E.; Kahan, J.; Olukiran, G.; Heckelmann, M.; Giamas, G.; Chandy, E.; Critchley, G. 分享 收藏
分享 收藏
分享 收藏
Development of Potent Mcl-1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen 开发有效的Mcl-1抑制剂: 源自DNA编码的化学文库筛选的大环的结构研究 Hekking, Koen F. W.; Maroto, Sergio; van Kekem, Kees; Haasjes, Frank S.; Slootweg, Jack C.; Oude Alink, Patrick G. B.; Dirks, Ron; Sardana, Malvika; Bolster, Marjon G.; Kuijpers, Brian; Smith, Dennis; Doodeman, Robin; Scheepstra, Marcel; Zech, Birgit; Mulvihill, Mark; Renzetti, Louis M.; Babiss, Lee; Centrella, Paolo A.; Clark, Matthew A.; Cuozzo, John W.; Guie, Marie-Aude; Sigel, Eric; Habeshian, Sevan; Hupp, Christopher D.; Liu, Julie; Thomson, Heather A.; Zhang, Ying; Keefe, Anthony D.; Muller, Gerhard; Gremmen, Stijn 分享 收藏
分享 收藏
Disease Course, Treatments, and Outcomes of Children With Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease Huang, Yannan; Sompii-Montgomery, Laura; Patti, Jessica; Pickering, Alex; Yasin, Shima; Do, Thuy; Baker, Elizabeth; Gao, Denny; Abdul-Aziz, Rabheh; Behrens, Edward M.; Canna, Scott; Clark, Matthew; Co, Dominic O.; Collins, Kathleen P.; Eberhard, Barbara; Friedman, Monica; Graham, Thomas B.; Hahn, Timothy; Hersh, Aimee O.; Hobday, Patricia; Holland, Michael J.; Huggins, Jennifer; Lu, Pai-Yue; Mannion, Melissa L.; Manos, Cynthia K.; Neely, Jessica; Onel, Karen; Orandi, Amir B.; Ramirez, Andrea; Reinhardt, Adam; Riskalla, Mona; Santiago, Laisa; Stoll, Matthew L.; Ting, Tracy; Grom, Alexei A.; Towe, Christopher; Schulert, Grant S. 分享 收藏
Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning Ahmad, Shabbir; Xu, Jin; Feng, Jianwen A.; Hutchinson, Ashley; Zeng, Hong; Ghiabi, Pegah; Dong, Aiping; Centrella, Paolo A.; Clark, Matthew A.; Guie, Marie-Aude; Guilinger, John P.; Keefe, Anthony D.; Zhang, Ying; Cerruti, Thomas; Cuozzo, John W.; von Rechenberg, Moritz; Bolotokova, Albina; Li, Yanjun; Loppnau, Peter; Seitova, Alma; Li, Yen-Yen; Santhakumar, Vijayaratnam; Brown, Peter J.; Ackloo, Suzanne; Halabelian, Levon 分享 收藏
Discovery of Novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa Ryan, M. Dominic; Parkes, Alastair L.; Corbett, David; Dickie, Anthony P.; Southey, Michelle; Andersen, Ole A.; Stein, Daniel B.; Barbeau, Olivier R.; Sanzone, Angelo; Thommes, Pia; Barker, John; Cain, Ricky; Compper, Christel; Dejob, Magali; Dorali, Alain; Etheridge, Donnya; Evans, Sian; Faulkner, Adele; Gadouleau, Elise; Gorman, Timothy; Haase, Denes; Holbrow-Wilshaw, Maisie; Krulle, Thomas; Li, Xianfu; Lumley, Christopher; Mertins, Barbara; Napier, Spencer; Odedra, Rajesh; Papadopoulos, Kostas; Roumpelakis, Vasileios; Spear, Kate; Trimby, Emily; Williams, Jennifer; Zahn, Michael; Keefe, Anthony D.; Zhang, Ying; Soutter, Holly T.; Centrella, Paolo A.; Clark, Matthew A.; Cuozzo, John W.; Dumelin, Christoph E.; Deng, Boer; Hunt, Avery; Sigel, Eric A.; Troast, Dawn M.; DeJonge, Boudewijn L. M. 分享 收藏
分享 收藏
Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening Lee, Esther C. Y.; McRiner, Andrew J.; Georgiadis, Katy E.; Liu, Julie; Wang, Zooey; Ferguson, Andrew D.; Levin, Benjamin; von Rechenberg, Moritz; Hupp, Christopher D.; Monteiro, Michael, I; Keefe, Anthony D.; Olszewski, Allison; Eyermann, Charles J.; Centrella, Paolo; Liu, Yanbin; Arora, Shilpi; Cuozzo, John W.; Zhang, Ying; Clark, Matthew A.; Huguet, Christelle; Kohlmann, Anna 分享 收藏
Bispecific Estrogen Receptor a Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening 双特异性雌激素受体a降解剂结合了使用DNA编码的化学文库筛选鉴定的新型结合剂 Disch, Jeremy S.; Duffy, Jennifer M.; Lee, Esther C. Y.; Gikunju, Diana; Chan, Betty; Levin, Benjamin; Monteiro, Michael, I; Talcott, Sarah A.; Lau, Anthony C.; Zhou, Fei; Kozhushnyan, Anton; Westlund, Neil E.; Mullins, Patrick B.; Yu, Yan; von Rechenberg, Moritz; Zhang, Junyi; Arnautova, Yelena A.; Liu, Yanbin; Zhang, Ying; McRiner, Andrew J.; Keefe, Anthony D.; Kohlmann, Anna; Clark, Matthew A.; Cuozzo, John W.; Huguet, Christelle; Arora, Shilpi 分享 收藏
Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy Nissink, J. Willem M.; Bazzaz, Sana; Blackett, Carolyn; Clark, Matthew A.; Collingwood, Olga; Disch, Jeremy S.; Gikunju, Diana; Goldberg, Kristin; Guilinger, John P.; Hardaker, Elizabeth; Hennessy, Edward J.; Jetson, Rachael; Keefe, Anthony D.; McCoull, William; McMurray, Lindsay; Olszewski, Allison; Overman, Ross; Pflug, Alexander; Preston, Marian; Rawlins, Philip B.; Rivers, Emma; Schimpl, Marianne; Smith, Paul; Truman, Caroline; Underwood, Elizabeth; Warwicker, Juli; Winter-Holt, Jon; Woodcock, Simon; Zhang, Ying 分享 收藏
Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry Cuozzo, John W.; Clark, Matthew A.; Keefe, Anthony D.; Kohlmann, Anna; Mulvihill, Mark; Ni, Haihong; Renzetti, Louis M.; Resnicow, Daniel, I; Ruebsam, Frank; Sigel, Eric A.; Thomson, Heather A.; Wang, Ce; Xie, Zhifeng; Zhang, Ying 分享 收藏
Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding McCloskey, Kevin; Sigel, Eric A.; Kearnes, Steven; Xue, Ling; Tian, Xia; Moccia, Dennis; Gikunju, Diana; Bazzaz, Sana; Chan, Betty; Clark, Matthew A.; Cuozzo, John W.; Guie, Marie-Aude; Guilinger, John P.; Huguet, Christelle; Hupp, Christopher D.; Keefe, Anthony D.; Mulhern, Christopher J.; Zhang, Ying; Riley, Patrick 分享 收藏
分享 收藏
分享 收藏
分享 收藏
Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action 具有新颖化学结构和异常作用方式的同工型选择性ATAD2化学探针 Fernandez-Montalvan, Amaury E.; Berger, Markus; Kuropka, Benno; Koo, Seong Joo; Badock, Volker; Weiske, Joerg; Puetter, Vera; Holton, Simon J.; Stoekigt, Detlef; ter Laak, Antonius; Centrella, Paolo A.; Clark, Matthew A.; Dumelin, Christoph E.; Sigel, Eric A.; Soutter, Holly H.; Troast, Dawn M.; Zhang, Ying; Cuozzo, John W.; Keefe, Anthony D.; Roche, Didier; Rodeschini, Vincent; Chaikuad, Apirat; Diaz-Saez, Laura; Bennett, James M.; Fedorov, Oleg; Huber, Kilian V. M.; Huebner, Jan; Weinmann, Hilmar; Hartung, Ingo V.; Gorjanacz, Matyas 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
