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L

Le Yu

southern medical university

H指数:27

被引数:2,084

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Synthetic lethal screens reveal p300/CBP as a vulnerability for GNAQ-driven uveal melanomas

合成致死筛选揭示p300/CBP是GNAQ驱动的眼葡萄膜黑色素瘤的易损性靶点

Nature Communications

IF15.7

2026-10-020

OAAI

Genome-Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes

全基因组与生命环境交互作用对脑成像表型的研究

Advanced Science

IF14.1

2025-11-290

OAAI

Sijia Wang; Meiyun Wang; Peng Zhang; Jingliang Cheng; Longjiang Zhang; Wenzhen Zhu; Shijun Qiu; Zuojun Geng; Guangbin Cui; Yongqiang Yu; Weihua Liao; Xi-Nian Zuo; Hui Zhang; Bo Gao; Xiaojun Xu; Tong Han; Zhenwei Yao; Quan Zhang; Feng Liu; Qiang Xu; Jiayuan Xu; Jilian Fu; Nana Liu; Yuan Ji; Jie Tang; Lining Guo; Mengge Liu; Xiaoxiao Xiao; Xiaoxuan Liu; Wei Li; Caihong Wang; Wei Wei; Dapeng Shi; Su Lui; Zhihan Yan; Feng Chen; Jing Zhang; Wen Shen; Yanwei Miao; Dawei Wang; Jia-Hong Gao; Yunjun Yang; Kai Xu; Junfang Xian; Bing Zhang; Xiaochu Zhang; Zhaoxiang Ye; Le Yu; Wen Qin; Meng Liang; Chunshui Yu; the CHIMGEN Consortium

Targeted degradation of endogenous YAP by nanobody bioPROTAC inhibits tumor progression

纳米抗体生物PROTAC介导的内源YAP靶向降解抑制肿瘤进展

Nature Communications

IF15.7

2025-10-230

OAAI

Deficient DNA mismatch repair and Nectin-4 expression in upper tract urothelial carcinoma (UTUC)

DNA错配修复缺陷和Nectin-4表达在上尿路尿路上皮癌(UTUC)中

Journal of Cancer Research and Clinical Oncology

IF2.8

2025-10-070

OA

Transcriptomic analysis provides insights into gonad development and sex reversal of cultured largefin longbarbel catfish (Hemibagrus macropterus)

转录组分析为养殖大鳍长 Barbels 鲶鱼 (Hemibagrus macropterus) 的性腺发育和性反转提供了见解。

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS

IF2.4

2025-10-010

PRE

New guidelines and definitions for type I photodynamic therapy

I型光动力疗法的新指南和定义

Chem. Soc. Rev.

IF39

2025-07-280

PRE

YAP Upregulation Contributes to Acquired Resistance to BET Inhibitors in Uveal Melanoma

YAP上调有助于脉络膜黑色素瘤对BET抑制剂的获得性耐药

Pigment Cell & Melanoma Research

IF2.6

2025-07-070

PRE

Flavonoids from aging tangerine peel alleviate OVA-induced allergic asthma through JAK/STAT signaling pathway in balb/c mice

来自老化橘皮中的类黄酮通过JAK/STAT信号通路缓解BALB/c小鼠卵清蛋白(OVA)诱导的过敏性哮喘

European Food Research and Technology

IF3.2

2025-07-040

PRE

Remolding probiotics for effective treatment of type 2 diabetes via oral administration

IF12.9

2025-04-010

PRE

Unveiling phosphofructokinase as the key target: an innovative strategy combining pull-down assays with optical imaging for snail-killing mechanism exploration

揭示磷酸果糖激酶为关键靶点：一种结合拉下实验与光学成像的创新策略，用于探索捕螺机制

SCIENCE CHINA-CHEMISTRY

IF9.7

2025-01-030

PRE

Emerging therapeutic strategies for metastatic uveal melanoma: Targeting driver mutations

PIGMENT CELL & MELANOMA RESEARCH

IF2.6

2024-02-274

PRE

Activated aggregation-induced emission therapeutics agents for triggering regulated cell death

激活的聚集诱导的发射治疗剂，用于触发调节性细胞死亡

IF13.7

2024-01-228

OAAI

Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)

BIOMATERIALS RESEARCH

IF9.6

2023-07-217

OAAI

Reciprocal positive regulation between BRD4 and YAP in GNAQ-mutant uveal melanoma cells confers sensitivity to BET inhibitors

PHARMACOLOGICAL RESEARCH

IF10.5

2022-10-015

PRE

PTEN loss confers sensitivity to rapalogs in clear cell renal cell carcinoma

PTEN缺失赋予透明细胞肾细胞癌对rapalogs的敏感性

ACTA PHARMACOLOGICA SINICA

IF8.4

2022-02-147

OA

Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence

葡萄膜黑色素瘤中BAP1和SF3B1突变的共同发生诱导细胞衰老

MOLECULAR ONCOLOGY

IF4.5

2021-11-1217

OA

BAP1 loss augments sensitivity to BET inhibitors in cancer cells

BAP1丢失增强癌细胞对BET抑制剂的敏感性

ACTA PHARMACOLOGICA SINICA

IF8.4

2021-11-0412

OA

AT-101 induces G1/G0 phase arrest via the -catenin/cyclin D1 signaling pathway in human esophageal cancer cells

ONCOLOGY REPORTS

IF3.9

2018-11-205

OAAI

TMC120 displayed potent cytotoxic effect on human cervical carcinoma through enhancing the polymerization of microtubules

IF3.1

2018-06-012

OAAI

ABT-263 induces G1/G0-phase arrest, apoptosis and autophagy in human esophageal cancer cells in vitro

ACTA PHARMACOLOGICA SINICA

IF8.4

2017-07-1024

OAAI