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C

Craig M. Goodwin

University of North Carolina at Chapel Hill
H指数:15
被引数:1,650

个人简介

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教育背景

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工作经历

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荣誉奖项

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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
Science
IF45.8
2024-01-010
OA
Jeffrey A. Klomp; Jennifer E. Klomp; Clint A. Stalnecker; Kirsten L. Bryant; A. Cole Edwards; Kristina Drizyte‐Miller; Priya S. Hibshman; J. Nathaniel Diehl; Ye S. Lee; Alexis Jean Morales; Khalilah E. Taylor; Sen Peng; Nhan L. Tran; Laura E. Herring; Alex W. Prevatte; Natalie K. Barker; Laura D. Hover; Jill F. Hallin; Saikat Chowdhury; Oluwadara Coker; Hey Min Lee; Craig M. Goodwin; Prson Gautam; Peter Olson; James G. Christensen; John Paul Shen; Scott Kopetz; Lee M. Graves; Kian‐Huat Lim; Andrea Wang‐Gillam; Krister Wennerberg; Adrienne D. Cox; Channing J. Der
Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer

联合CDK4/6抑制剂治疗KRAS突变型胰腺癌

CANCER RESEARCH
IF16.6
2022-11-0857
OA
Goodwin, Craig M.; Waters, Andrew M.; Klomp, Jennifer E.; Javaid, Sehrish; Bryant, Kirsten L.; Stalnecker, Clint A.; Drizyte-Miller, Kristina; Papke, Bjoern; Yang, Runying; Amparo, Amber M.; Ozkan-Dagliyan, Irem; Baldelli, Elisa; Calvert, Valerie; Pierobon, Mariaelena; Sorrentino, Jessica A.; Beelen, Andrew P.; Bublitz, Natalie; Luethen, Mareen; Wood, Kris C.; Petricoin III, Emanuel F.; Sers, Christine; McRee, Autumn J.; Cox, Adrienne D.; Der, Channing J.
Functional and biological heterogeneity of KRASQ61 mutations

KRASQ61突变的功能和生物学异质性

SCIENCE SIGNALING
IF6.6
2022-08-0915
OA
Huynh, Minh, V; Hobbs, G. Aaron; Schaefer, Antje; Pierobon, Mariaelena; Carey, Leiah M.; Diehl, J. Nathaniel; DeLiberty, Jonathan M.; Thurman, Ryan D.; Cooke, Adelaide R.; Goodwin, Craig M.; Cook, Joshua H.; Lin, Lin; Waters, Andrew M.; Rashid, Naim U.; Petricoin, Emanuel F., III; Campbell, Sharon L.; Haigis, Kevin M.; Simeone, Diane M.; Lyssiotis, Costas A.; Cox, Adrienne D.; Der, Channing J.
Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma

同时抑制ERK和法尼基转移酶抑制HRAS突变型头颈部鳞状细胞癌的生长

MOLECULAR CANCER THERAPEUTICS
IF5.5
2022-02-2814
OA
Javaid, Sehrish; Schaefer, Antje; Goodwin, Craig M.; Nguyen, Victoria V.; Massey, Frances L.; Pierobon, Mariaelena; Gambrell-Sanders, Da'jhnae; Waters, Andrew M.; Lambert, Kathryn N.; Diehl, J. Nathaniel; Hobbs, G. Aaron; Wood, Kris C.; Petricoin, Emanuel F., III; Der, Channing J.; Cox, Adrienne D.
CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment

CHK1保护致癌KRAS表达细胞免受DNA损伤，是胰腺癌治疗的靶点

CELL REPORTS
IF6.9
2021-11-0123
OAAI
Klomp, Jennifer E.; Lee, Ye S.; Goodwin, Craig M.; Papke, Bjorn; Klomp, Jeff A.; Waters, Andrew M.; Stalnecker, Clint A.; DeLiberty, Jonathan M.; Drizyte-Miller, Kristina; Yang, Runying; Diehl, J. Nathaniel; Yin, Hongwei H.; Pierobon, Mariaelena; Baldelli, Elisa; Ryan, Meagan B.; Li, Siqi; Peterson, Jackson; Smith, Amber R.; Neal, James T.; McCormick, Aaron K.; Kuo, Calvin J.; Counter, Christopher M.; Petricoin, Emanuel F.; Cox, Adrienne D.; Bryant, Kirsten L.; Der, Channing J.
Targeting p130Cas-and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

靶向p130Cas-and微管依赖的MYC调节使胰腺癌对ERK MAPK抑制敏感

CELL REPORTS
IF6.9
2021-06-0118
OAAI
Waters, Andrew M.; Khatib, Tala O.; Papke, Bjoern; Goodwin, Craig M.; Hobbs, G. Aaron; Diehl, J. Nathaniel; Yang, Runying; Edwards, A. Cole; Walsh, Katherine H.; Sulahian, Rita; McFarland, James M.; Kapner, Kevin S.; Gilbert, Thomas S. K.; Stalnecker, Clint A.; Javaid, Sehrish; Barkovskaya, Anna; Grover, Kajal R.; Hibshman, Priya S.; Blake, Devon R.; Schaefer, Antje; Nowak, Katherine M.; Klomp, Jennifer E.; Hayes, Tikvah K.; Kassner, Michelle; Tang, Nanyun; Tanaseichuk, Olga; Chen, Kaisheng; Zhou, Yingyao; Kalkat, Manpreet; Herring, Laura E.; Graves, Lee M.; Penn, Linda Z.; Yin, Hongwei H.; Aguirre, Andrew J.; Hahn, William C.; Cox, Adrienne D.; Der, Channing J.
Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

Raf-mek-erk级联的低剂量垂直抑制导致KRAS突变型癌症的凋亡死亡

CELL REPORTS
IF6.9
2020-06-0171
OAAI
Ozkan-Dagliyan, Irem; Diehl, J. Nathaniel; George, Samuel D.; Schaefer, Antje; Papke, Bjoern; Klotz-Noack, Kathleen; Waters, Andrew M.; Goodwin, Craig M.; Gautam, Prson; Pierobon, Mariaelena; Peng, Sen; Gilbert, Thomas S. K.; Lin, Kevin H.; Dagliyan, Onur; Wennerberg, Krister; Petricoin, Emanuel F., III; Tran, Nhan L.; Bhagwat, Shripad, V; Tiu, Ramon, V; Peng, Sheng-Bin; Herring, Laura E.; Graves, Lee M.; Sers, Christine; Wood, Kris C.; Cox, Adrienne D.; Der, Channing J.
REPLY TO TRAN ET AL.: Dimeric KRAS protein-protein interaction stabilizers
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2020-02-1113
OAAI
Kessler, Dirk; Gollner, Andreas; Gmachl, Michael; Mantoulidis, Andreas; Martin, Laetitia J.; Zoephel, Andreas; Mayer, Moriz; Covini, David; Fischer, Silke; Gerstberger, Thomas; Gmaschitz, Teresa; Goodwin, Craig; Greb, Peter; Haering, Daniela; Hela, Wolfgang; Hoffmann, Johann; Karolyi-Oezguer, Jale; Knesl, Petr; Kornigg, Stefan; Koegl, Manfred; Kousek, Roland; Lamarre, Lyne; Moser, Franziska; Munico-Martinez, Silvia; Peinsipp, Christoph; Phan, Jason; Rinnenthal, Joerg; Sai, Jiqing; Salamon, Christian; Scherbantin, Yvonne; Schipany, Katharina; Schnitzer, Renate; Schrenk, Andreas; Sharps, Bernadette; Siszler, Gabriella; Sun, Qi; Waterson, Alex; Wolkerstorfer, Bernhard; Zeeb, Markus; Pearson, Mark; Fesik, Stephen W.; McConnell, Darryl B.
Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer

非典型KRASG12R突变体在胰腺癌的PI3K信号传导和巨胞饮作用中受损

CANCER DISCOVERY
IF33.3
2020-01-09139
OAAI
Hobbs, G. Aaron; Baker, Nicole M.; Miermont, Anne M.; Thurman, Ryan D.; Pierobon, Mariaelena; Tran, Timothy H.; Anderson, Andrew O.; Waters, Andrew M.; Diehl, J. Nathaniel; Papke, Bjoern; Hodge, Richard G.; Klomp, Jennifer E.; Goodwin, Craig M.; DeLiberty, Jonathan M.; Wang, Junning; Ng, Raymond W. S.; Gautam, Prson; Bryant, Kirsten L.; Esposito, Dominic; Campbell, Sharon L.; Petricoin, Emanuel F., III; Simanshu, Dhirendra K.; Aguirre, Andrew J.; Wolpin, Brian M.; Wennerberg, Krister; Rudloff, Udo; Cox, Adrienne D.; Der, Channing J.
Drugging an undruggable pocket on KRAS

在KRAS上给一个不可下药的口袋下药

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2019-07-22314
OAAI
Kessler, Dirk; Gmachl, Michael; Mantoulidis, Andreas; Martin, Laetitia J.; Zoephel, Andreas; Mayer, Moriz; Gollner, Andreas; Covini, David; Fischer, Silke; Gerstberger, Thomas; Gmaschitz, Teresa; Goodwin, Craig; Greb, Peter; Haring, Daniela; Hela, Wolfgang; Hoffmann, Johann; Karolyi-Oezguer, Jale; Knesi, Petr; Kornigg, Stefan; Koegl, Manfred; Kousek, Roland; Lamarre, Lyne; Moser, Franziska; Munico-Martinez, Silvia; Peinsipp, Christoph; Phan, Jason; Rinnenthal, Joerg; Sai, Jiqing; Salamon, Christian; Scherbantin, Yvonne; Schipany, Katharina; Schnitzer, Renate; Schrenk, Andreas; Sharps, Bernadette; Siszler, Gabriella; Sun, Qi; Waterson, Alex; Wolkerstorfer, Bernhard; Zeeb, Markus; Pearson, Mark; Fesik, Stephen W.; McConnell, Darryl B.
Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors
FEBS LETTERS
IF3
2016-12-1961
OAAI
Lee, Taekyu; Bian, Zhiguo; Zhao, Bin; Hogdal, Leah J.; Sensintaffar, John L.; Goodwin, Craig M.; Belmar, Johannes; Shaw, Subrata; Tarr, James C.; Veerasamy, Nagarathanam; Matulis, Shannon M.; Koss, Brian; Fischer, Melissa A.; Arnold, Allison L.; Camper, DeMarco V.; Browning, Carrie F.; Rossanese, Olivia W.; Budhraja, Amit; Opferman, Joseph; Boise, Lawrence H.; Savona, Michael R.; Letai, Anthony; Olejniczak, Edward T.; Fesik, Stephen W.

研究方向

暂未获取到该数据
A
Adrienne D. Cox
H 指数:73论文数:517被引数:1.9万
C
Channing J. Der
H 指数:127论文数:1,046被引数:7.1万
A
Andrew M. Waters
H 指数:18论文数:348被引数:3,042
S
Stephen W. Fesik
H 指数:97论文数:432被引数:4.4万
M
Mariaelena Pierobon
H 指数:39论文数:385被引数:7,135
J
J. Nathaniel Diehl
H 指数:18论文数:49被引数:1,852
E
Edward T. Olejniczak
H 指数:63论文数:246被引数:1.3万
C
Clint A. Stalnecker
H 指数:17论文数:211被引数:4,416
S
Sehrish Javaid
H 指数:6论文数:102被引数:250
B
Bjoern Papke
H 指数:16论文数:134被引数:3,001