Paul J. Lehner - Publications, H-index & Citations

Paul J. Lehner

University of Cambridge

84H指数

439论文数

2.6W被引数

收录论文 140

发表时间

Reduced Cas9 transgene silencing by incorporation of intron sequences 通过内含子序列的整合降低Cas9转基因沉默

Nature Communications

IF15.7

2025-11-27

OAAI

Sophia Arana; Peter P. Du; Alun Vaughan-Jackson; Nora Enright; Kaitlyn Spees; Raeline Valbuena; Cesar A. Garcia; Thien Nguyen; Anthony Venida; Marta Seczynska; Lacramioara Bintu; Paul J. Lehner; Laura M. Prolo; Michael C. Bassik

CRISPR-Cas9 genetic screens reveal regulation of TMPRSS2 by the Elongin BC-VHL complex

SCIENTIFIC REPORTS

IF3.9

2025-04-07

OAAI

Gabaev, Ildar; Rowland, Alexandra; Jovanovic, Emilija; Gawden-Bone, Christian M.; Crozier, Thomas W. M.; Teixeira-Silva, Ana; Greenwood, Edward J. D.; Gerber, Pehuen Pereyra; Wit, Niek; Nathan, James A.; Matheson, Nicholas J.; Lehner, Paul J.

RNA binding by Periphilin plays an essential role in initiating silencing by the HUSH complex

NUCLEIC ACIDS RESEARCH

IF13.1

2024-12-11

OAAI

Bloor, Stuart; Wit, Niek; Lehner, Paul J.

The HUSH epigenetic repressor complex silences PML nuclear body- associated HSV-1 quiescent genomes

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-11-26

PREAI

Roubille, Simon; Escure, Tristan; Juillard, Franceline; Corpet, Armelle; Neplaz, Remi; Binda, Olivier; Seurre, Coline; Gonin, Mathilde; Bloor, Stuart; Cohen, Camille; Texier, Pascale; Haigh, Oscar; Pascual, Olivier; Ganor, Yonatan; Magdinier, Frederique; Labetoulle, Marc; Lehner, Paul J.; Lomonte, Patrick

A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis (Vol 14, 4816, 2023)

NATURE COMMUNICATIONS

IF15.7

2024-03-26

OAAI

Dickson, Anna S.; Pauzaite, Tekle; Arnaiz, Esther; Ortmann, Brian M.; West, James A.; Volkmar, Norbert; Martinelli, Anthony W.; Li, Zhaoqi; Wit, Niek; Vitkup, Dennis; Kaser, Arthur; Lehner, Paul J.; Nathan, James A.

A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis (vol 14, 4816, 2023)

NATURE COMMUNICATIONS

IF15.7

2023-11-27

OAAI

MORC3 represses the HCMV major immediate early promoter in myeloid cells in the absence of PML nuclear bodies

JOURNAL OF MEDICAL VIROLOGY

IF4.6

2023-11-27

OAAI

Champion, Anna; Rowland, Alexandra; Yee, Levia; van den Boomen, Dick; Reeves, Matthew; Lehner, Paul; Sinclair, John; Poole, Emma

As a matter of fat: Emerging roles of lipid-sensitive E3 ubiquitin ligases 作为脂肪的问题: 脂质敏感的E3泛素连接酶的新兴作用

BIOESSAYS

IF2.7

2023-10-27

OAAI

Gawden-Bone, Christian M.; Lehner, Paul J.; Volkmar, Norbert

A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis

NATURE COMMUNICATIONS

IF15.7

2023-08-09

OAAI

Article Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity

CELL REPORTS

IF6.9

2023-06-01

OAAI

Potts, Martin; Fletcher-Etherington, Alice; Nightingale, Katie; Mescia, Federica; Bergamaschi, Laura; Calero-Nieto, Fernando J.; Antrobus, Robin; Williamson, James; Parsons, Harriet; Huttlin, Edward L.; Kingston, Nathalie; Gottgens, Berthold; Bradley, John R.; Lehner, Paul J.; Matheson, Nicholas J.; Smith, Kenneth G. C.; Wills, Mark R.; Lyons, Paul A.; Weekes, Michael P.

The sound of silence: mechanisms and implications of HUSH complex function

TRENDS IN GENETICS

IF16.3

2023-04-01

OAAI

Seczynska, Marta; Lehner, Paul J.

Altered plasma membrane abundance of the sulfatide-binding protein NF155 links glycosphingolipid imbalances to demyelination

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-03-30

OAAI

McKie, Shannon J.; Nicholson, Alex S.; Smith, Emily; Fawke, Stuart; Caroe, Eve R.; Williamson, James C.; Butt, Benjamin G.; Kolarova, Denisa; Peterka, Ondrej; Holcapek, Michal; Lehner, Paul J.; Graham, Stephen C.; Deane, Janet E.

Cigarette smoke preferentially induces full length ACE2 expression in differentiated primary human airway cultures but does not alter the efficiency of cellular SARS-CoV-2 infection

HELIYON

IF3.6

2023-03-01

OAAI

Porter, Linsey M.; Guo, Wenrui; Crozier, Thomas WM.; Greenwood, Edward JD.; Ortmann, Brian; Kottmann, Daniel; Nathan, James A.; Mahadeva, Ravindra; Lehner, Paul J.; McCaughan, Frank

Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes

NATURE CELL BIOLOGY

IF19.1

2023-01-12

OAAI

Sparbier, Christina E.; Gillespie, Andrea; Gomez, Juliana; Kumari, Nishi; Motazedian, Ali; Chan, Kah Lok; Bell, Charles C.; Gilan, Omer; Chan, Yih-Chih; Popp, Sarah; Gough, Daniel J.; Eckersley-Maslin, Melanie A.; Dawson, Sarah-Jane; Lehner, Paul J.; Sutherland, Kate D.; Ernst, Patricia; McGeehan, Gerard M.; Lam, Enid Y. N.; Burr, Marian L.; Dawson, Mark A.

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

ELIFE

IF0

2022-11-24

OAAI

Randzavola, Lyra O.; Mortimer, Paige M.; Garside, Emma; Dufficy, Elizabeth R.; Schejtman, Andrea; Roumelioti, Georgia; Yu, Lu; Pardo, Mercedes; Spirohn, Kerstin; Tolley, Charlotte; Brandt, Cordelia; Harcourt, Katherine; Nichols, Esme; Nahorski, Mike; Woods, Geoff; Williamson, James C.; Suresh, Shreehari; Sowerby, John M.; Matsumoto, Misaki; Santos, Celio X. C.; Kiar, Cher Shen; Mukhopadhyay, Subhankar; Rae, William M.; Dougan, Gordon J.; Grainger, John; Lehner, Paul J.; Calderwood, Michael A.; Choudhary, Jyoti; Clare, Simon; Speak, Anneliese; Santilli, Giorgia; Bateman, Alex; Smith, Kenneth G. C.; Magnani, Francesca; Thomas, David C.

Human Cytomegalovirus Infection of Epithelial Cells Increases SARS-CoV-2 Superinfection by Upregulating the ACE2 Receptor

JOURNAL OF INFECTIOUS DISEASES

IF4.5

2022-11-21

OAAI

Perera, Marianne R.; Greenwood, Edward J. D.; Crozier, Thomas W. M.; Elder, Elizabeth G.; Schmitt, Janika; Crump, Colin M.; Lehner, Paul J.; Wills, Mark R.; Sinclair, John H.

USING FORWARD GENETIC SCREENS AND NOVEL HUMAN ALVEOLAR ORGANOID MODELS TO STUDY SURFACTANT PROTEIN C TRAFFICKING IN HEATH AND DISEASE

THORAX

IF7.7

2022-11-11

PREAI

Rutherford, E. N.; van den Boomen, D.; Lim, K.; Lehner, P. J.; Rawlins, E. L.; Marciniak, S. J.; Dickens, J. A.

Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2

EMBO JOURNAL

IF8.3

2022-08-22

OAAI

Volkmar, Norbert; Gawden-Bone, Christian M.; Williamson, James C.; Nixon-Abell, Jonathon; West, James A.; St George-Hyslop, Peter H.; Kaser, Arthur; Lehner, Paul J.

Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID

EBIOMEDICINE

IF10.8

2022-07-01

OAAI

Krishna, Benjamin A.; Lim, Eleanor Y.; Mactavous, Lenette; Lyons, Paul A.; Doffinger, Rainer; Bradley, John R.; Smith, Kenneth G. C.; Sinclair, John; Matheson, Nicholas J.; Lehner, Paul J.; Wills, Mark R.; Sithole, Nyaradzai

SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies SARS-CoV-2宿主关闭影响先天NK细胞功能，但抗体依赖性NK活性通过非刺突抗体强烈激活

ELIFE

IF0

2022-05-19

OAAI

Fielding, Ceri Alan; Sabberwal, Pragati; Williamson, James C.; Greenwood, Edward J. D.; Crozier, Thomas W. M.; Zelek, Wioleta; Seow, Jeffrey; Graham, Carl; Huettner, Isabella; Edgeworth, Jonathan D.; Price, David A.; Morgan, Paul B.; Ladell, Kristin; Eberl, Matthias; Humphreys, Ian R.; Merrick, Blair; Doores, Katie; Wilson, Sam J.; Lehner, Paul J.; Wang, Eddie C. Y.; Stanton, Richard J.

研究方向