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J

Jules A. A. C. Heuberger

Centre for Human Drug Research
H指数:20
被引数:1,403

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荣誉奖项

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Sustained pharmacodynamic effects of S-ketamine on cortical excitability and resting-state brain activity: A randomized, placebo-controlled trial

S-氯胺酮对皮层兴奋性和静息态脑活动持续药效作用的随机、安慰剂对照试验

British Journal of Clinical Pharmacology
IF3
2026-06-240
OAAI
Catherine M. K. E. de Cuba; Annika A. de Goede; Joost. C. van Mechelen; Laura G. J. M. Borghans; Liam van der Aa; Erik Olofsen; Maria J. Juachon; Robert J. Doll; Amy Gillespie; Catherine J. Harmer; Gabriël E. Jacobs; Jules A. A. C. Heuberger
Transcranial Magnetic Stimulation as a Translational Biomarker in Early-Phase Anti-Seizure Medication Development: A Randomized, Double-Blind, Placebo-Controlled Study in Generalized Epilepsy

经颅磁刺激作为早期抗癫痫药物开发中的转化生物标志物：一项在全身性癫痫中的随机、双盲、安慰剂对照研究

CLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
2026-05-010
OAAI
de Cuba, Catherine M. E.; Ruijs, Titia Q.; de Goede, Annika A.; Doll, Robert J.; Juachon, Maria; van Putten, Michel J. A. M.; Groeneveld, Geert Jan; Heuberger, Jules A. A. C.
Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

实验性eIF2B激活剂DNL343在TDP-43病理学的临床前模型和随机临床试验中的ALS患者中调节整合应激反应

Nature Communications
IF15.7
2025-08-180
OAAI
Brittany N. Flores; Seungyoon B. Yu; Isaac V. Cohen; Melania H. Fanok; Wei Luan; Romeo D. Maciuca; Linus D. Sun; Richard M. Tsai; Maurits Vissers; Lars Smits; Tommy M. Bunte; Anna Bakardjiev; Srijana Balasundar; Meredith E. K. Calvert; Marcus Y. Chin; Sarah K. Dobbins; William E. Dowdle; Meng Fang; Jules A. A. C. Heuberger; Connie L. Ha; Fen Huang; Takashi Miyamoto; Maksim Osipov; Lidia Madrid San Martin; Katie Saund; David Tatarakis; Anthony Q. Vu; Chenling Xiong; Gene W. Yeo; Geert Jan Groeneveld; Leonard H. van den Berg; Shyeilla Dhuria; Anthony A. Estrada; Danna Jennings; Thomas Sandmann; Carole Ho; Kimberly Scearce-Levie; Ernie Yulyaningsih; Adam K. Walker; Gilbert Di Paolo; Lesley A. Kane; Matthew D. Troyer; Joseph W. Lewcock
Safety, Pharmacokinetics, and Pharmacodynamics of a First-in-Class ClC-1 Inhibitor to Enhance Muscle Excitability: Phase I Randomized Controlled Trial
CLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
2024-12-091
OAAI
Ruijs, Titia Q.; de Cuba, Catherine M. K. E.; Heuberger, Jules A. A. C.; Hutchison, John; Bold, Jane; Gronnebaek, Thomas S.; Jensen, Klaus G.; Chin, Eva; Quiroz, Jorge A.; Petersen, Thomas K.; Flagstad, Peter; de Kam, Marieke L.; van Esdonk, Michiel J.; Klaassen, Erica; Doll, Robert J.; Koopmans, Ingrid W.; de Goede, Annika A.; Aulin, Linda B. S.; Pedersen, Thomas H.; Groeneveld, Geert Jan
The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2024-03-206
PRE
Skov, Martin; Ruijs, Titia Q.; Gronnebaek, Thomas S.; Skals, Marianne; Riisager, Anders; Winther, Jeppe Blichfeldt; Dybdahl, Kamilla Lohde Tordrup; Findsen, Anders; Morgen, Jeanette J.; Huus, Nete; Broch-Lips, Martin; Nielsen, Ole B.; de Cuba, Catherine M. K. E.; Heuberger, Jules A. A. C.; de Kam, Marieke L.; Tannemaat, Martijn; Verschuuren, Jan J. G. M.; Knutsen, Lars J. S.; Kelly, Nicholas M.; Jensen, Klaus G.; Arnold, William D.; Burghes, Arthur H.; Olesen, Claus; Bold, Jane; Petersen, Thomas K.; Quiroz, Jorge A.; Hutchison, John; Chin, Eva R.; Groeneveld, Geert J.; Pedersen, Thomas H.
Administration of oxathridine, a first-in-class histamine-3 receptor partial agonist in healthy male volunteers: Central nervous system depression and pseudo-hallucinations
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
IF3
2023-10-110
PRE
Dijkstra, Francis M.; Zuiker, Rob G. J. A.; Heuberger, Jules A. A. C.; Kanhai, Kawita M. S.; De Kam, Marieke; Duvauchelle, Thierry; Lecomte, Jeanne-Marie; Labeeuw, Olivier; Landais, Laurent; Ligneau, Xavier; Robert, Philippe; Capet, Marc; Schwartz, Jean-Charles; van Gerven, Joop M. A.
The Integrated Stress Response Is Modulated by eIF2B Agonist DNL343: Results From Phase 1 Healthy Subject and Phase 1b ALS Patient Studies
NEUROLOGY
IF8.5
2023-04-253
PRE
Sun, Linus; Tsai, Richard; Yulyaningsih, Ernie; Fanok, Melania; Vissers, Maurits; Heuberger, Jules; Flores, Brittany; Huang, Fen; Kane, Lesley; Cohen, Isaac; Dhuria, Shyeilla; Fang, Meng; Estrada, Anthony; Osipov, Maksim; Willman-Yoswa, Brent; Maciuca, Romeo; Dobbins, Sarah; Chau, Ronnie; Earr, Timothy; Nguyen, Hoang; Lopez, Isabel; Scearce-Levie, Kimberly; Bunte, Tommy; Van den Berg, Leonard; Ho, Carole; Groeneveld, Geert-Jan; Troyer, Matthew
LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease
MOVEMENT DISORDERS
IF7.6
2023-02-1831
OAAI
Jennings, Danna; Huntwork-Rodriguez, Sarah; Vissers, Maurits F. J. M.; Daryani, Vinay M.; Diaz, Dolores; Goo, Marisa S.; Chen, John J.; Maciuca, Romeo; Fraser, Kyle; Mabrouk, Omar S.; van de Wetering de Rooij, Jeroen; Heuberger, Jules A. A. C.; Groeneveld, Geert Jan; Borin, Marie T.; Cruz-Herranz, Andres; Graham, Danielle; Scearce-Levie, Kimberly; De Vicente, Javier; Henry, Anastasia G.; Chin, Peter; Ho, Carole; Troyer, Matthew D.
Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I/Ib studies in healthy subjects and patients

新型RIPK1抑制剂SAR443060 (DNL747) 治疗神经退行性疾病的安全性，药代动力学和靶标参与: 健康受试者和患者的随机，安慰剂对照，双盲I/Ib期研究

CTS-CLINICAL AND TRANSLATIONAL SCIENCE
IF2.8
2022-06-0140
OA
Vissers, Maurits F. J. M.; Heuberger, Jules A. A. C.; Groeneveld, Geert Jan; Nijhuis, Jerome Oude; De Deyn, Peter Paul; Hadi, Salah; Harris, Jeffrey; Tsai, Richard M.; Cruz-Herranz, Andres; Huang, Fen; Tong, Vincent; Erickson, Rebecca; Zhu, Yuda; Scearce-Levie, Kimberly; Hsiao-Nakamoto, Jennifer; Tang, Xinyan; Chang, Megan; Fox, Brian M.; Pomponio, Robert J.; Alonso-Alonso, Miguel; Zilberstein, Moshe; Atassi, Nazem; Troyer, Matthew D.; Ho, Carole

研究方向

暂未获取到该数据
G
Geert Jan Groeneveld
H 指数:37论文数:222被引数:4,905
A
Adam F. Cohen
H 指数:54论文数:435被引数:1.1万
M
Marieke L. de Kam
H 指数:29论文数:114被引数:2,865
T
Titia Q. Ruijs
H 指数:5论文数:15被引数:164
A
Annika A. de Goede
H 指数:10论文数:25被引数:259
E
Erica S. Klaassen
H 指数:19论文数:74被引数:957
K
Kimberly Scearce‐Levie
H 指数:51论文数:124被引数:1.0万
C
Catherine M.K.E. de Cuba
H 指数:3论文数:7被引数:64
A
Andriy A. Gorbenko
H 指数:2论文数:9被引数:24
L
Linda E. Klumpers
H 指数:11论文数:26被引数:863