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Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening 通过结合AsCas12a基因敲入小鼠与超紧凑型筛选技术，推进基因工程工具箱的发展。 Jin, Wei; Deng, Yexuan; La Marca, John E.; Lelliott, Emily J.; Diepstraten, Sarah T.; Konig, Christina; Tai, Lin; Snetkova, Valentina; Dorighi, Kristel M.; Hoberecht, Luke; Hedditch, Millicent G.; Whelan, Lauren; Healey, Geraldine; Fayle, Dan; Lau, Kieran; Potts, Margaret A.; Chen, Moore Z.; Johnston, Angus P. R.; Liao, Yang; Shi, Wei; Kueh, Andrew J.; Haley, Benjamin; Fortin, Jean-Philippe 分享 收藏
Towards designing improved cancer immunotherapy targets with a peptide-MHC-I presentation model, HLApollo 为设计改进的癌症免疫治疗靶点，采用肽-MHC-I呈递模型HLApollo。 Thrift, William John; Lounsbury, Nicolas W.; Broadwell, Quade; Heidersbach, Amy; Freund, Emily; Abdolazimi, Yassan; Phung, Qui T.; Chen, Jieming; Capietto, Aude-Helene; Tong, Ann-Jay; Rose, Christopher M.; Blanchette, Craig; Lill, Jennie R.; Haley, Benjamin; Delamarre, Lelia; Bourgon, Richard; Liu, Kai; Jhunjhunwala, Suchit 分享 收藏
Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform Dorighi, Kristel M.; Zhu, Anqi; Fortin, Jean-Philippe; Lo, Jerry Hung-Hao; Sudhamsu, Jawahar; Wendorff, Timothy J.; Durinck, Steffen; Callow, Marinella; Foster, Scott A.; Haley, Benjamin 分享 收藏
Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage Tong, Ann-Jay; Leylek, Rebecca; Herzner, Anna-Maria; Rigas, Diamanda; Wichner, Sara; Blanchette, Craig; Tahtinen, Siri; Kemball, Christopher C.; Mellman, Ira; Haley, Benjamin; Freund, Emily C.; Delamarre, Lelia 分享 收藏
Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity Guidi, Riccardo; Wedeles, Christopher; Xu, Daqi; Kolmus, Krzysztof; Headland, Sarah E.; Teng, Grace; Guillory, Joseph; Zeng, Yi Jimmy; Cheung, Tommy K.; Chaudhuri, Subhra; Modrusan, Zora; Liang, Yuxin; Horswell, Stuart; Haley, Benjamin; Rutz, Sascha; Rose, Christopher; Franke, Yvonne; Kirkpatrick, Donald S.; Hackney, Jason A.; Wilson, Mark S. 分享 收藏
Systematic discovery of neoepitope-HLA pairs for neoantigens shared among patients and tumor types Gurung, Hem R.; Heidersbach, Amy J.; Darwish, Martine; Chan, Pamela Pui Fung; Li, Jenny; Beresini, Maureen; Zill, Oliver A.; Wallace, Andrew; Tong, Ann-Jay; Hascall, Dan; Torres, Eric; Chang, Andy; Lou, Kenny 'Hei-Wai'; Abdolazimi, Yassan; Hammer, Christian; Xavier-Magalhaes, Ana; Marcu, Ana; Vaidya, Samir; Le, Daniel D.; Akhmetzyanova, Ilseyar; Oh, Soyoung A.; Moore, Amanda J.; Uche, Uzodinma N.; Laur, Melanie B.; Notturno, Richard J.; Ebert, Peter J. R.; Blanchette, Craig; Haley, Benjamin; Rose, Christopher M. 分享 收藏
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TEAD Proteins Associate With DNA Repair Proteins to Facilitate Cellular Recovery From DNA Damage Calses, Philamer C.; Pham, Victoria C.; Guarnaccia, Alissa D.; Choi, Meena; Verschueren, Erik; Bakker, Sietske T.; Pham, Trang H.; Hinkle, Trent; Liu, Chad; Chang, Matthew T.; Kljavin, Noelyn; Bakalarski, Corey; Haley, Benjamin; Zou, Jianing; Yan, Cuicui; Song, Xia; Lin, Xiaoyan; Rowntree, Rebecca; Ashworth, Alan; Dey, Anwesha; Lill, Jennie R. 分享 收藏
Generation of a CRISPR activationmouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance (vol 13, 4739, 2022) Deng, Yexuan; Diepstraten, Sarah T.; Potts, Margaret A.; Giner, Goknur; Trezise, Stephanie; Ng, Ashley P.; Healey, Gerry; Kane, Serena R.; Cooray, Amali; Behrens, Kira; Heidersbach, Amy; Kueh, Andrew J.; Pal, Martin; Wilcox, Stephen; Tai, Lin; Alexander, Warren S.; Visvader, Jane E.; Nutt, Stephen L.; Strasser, Andreas; Haley, Benjamin; Zhao, Quan; Kelly, Gemma L.; Herold, Marco J. 分享 收藏
EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation EHMT2甲基转移酶控制肺中的细胞身份，并且是KRAS G12D肿瘤发展和传播所必需的 Pribluda, Ariel; Daemen, Anneleen; Lima, Anthony Nelson; Wang, Xi; Hafner, Marc; Poon, Chungkee; Modrusan, Zora; Katakam, Anand Kumar; Foreman, Oded; Eastham, Jefferey; Hung, Jefferey; Haley, Benjamin; Garcia, Julia T.; Jackson, Erica L.; Junttila, Melissa R. 分享 收藏
Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance Deng, Yexuan; Diepstraten, Sarah T.; Potts, Margaret A.; Giner, Goeknur; Trezise, Stephanie; Ng, Ashley P.; Healey, Gerry; Kane, Serena R.; Cooray, Amali; Behrens, Kira; Heidersbach, Amy; Kueh, Andrew J.; Pal, Martin; Wilcox, Stephen; Tai, Lin; Alexander, Warren S.; Visvader, Jane E.; Nutt, Stephen L.; Strasser, Andreas; Haley, Benjamin; Zhao, Quan; Kelly, Gemma L.; Herold, Marco J. 分享 收藏
High-efficiency nonviral CRISPR/Cas9-mediated gene editing of human T cells using plasmid donor DNA 使用质粒供体DNA对人T细胞进行高效非病毒CRISPR/Cas9-mediated基因编辑 Oh, Soyoung A. A.; Senger, Kate; Madireddi, Shravan; Akhmetzyanova, Ilseyar; Ishizuka, Isabel E. E.; Tarighat, Somayeh; Lo, Jerry H. H.; Shaw, David; Haley, Benjamin; Rutz, Sascha 分享 收藏
Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors Savill, Kristin M. Zimmerman; Lee, Brian B.; Oeh, Jason; Lin, Jie; Lin, Eva; Chung, Wei-Jen; Young, Amy; Chen, Wennie; Mis, Monika; Mesh, Kathryn; Eastham, Jeffrey; Gnad, Florian; Jiang, Zhaoshi; Stawiski, Eric W.; Haley, Benjamin; Daemen, Anneleen; Wang, Xiaojing; Koeppen, Hartmut; Modrusan, Zora; Martin, Scott E.; Sampath, Deepak; Lin, Kui 分享 收藏
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines IL-1和IL-1ra是对RNA疫苗的炎症反应的关键调节因子 Tahtinen, Siri; Tong, Ann-Jay; Himmels, Patricia; Oh, Jaehak; Paler-Martinez, Andres; Kim, Leesun; Wichner, Sara; Oei, Yoko; McCarron, Mark J.; Freund, Emily C.; Amir, Zhainib Adel; de la Cruz, Cecile C.; Haley, Benjamin; Blanchette, Craig; Schartner, Jill M.; Ye, Weilan; Yadav, Mahesh; Sahin, Ugur; Delamarre, Lelia; Mellman, Ira 分享 收藏
CRAF dimerization with ARAF regulates KRAS-driven tumor growth Venkatanarayan, Avinashnarayan; Liang, Jason; Yen, Ivana; Shanahan, Frances; Haley, Benjamin; Phu, Lilian; Verschueren, Erik; Hinkle, Trent B.; Kan, David; Segal, Ehud; Long, Jason E.; Lima, Tony; Liau, Nicholas P. D.; Sudhamsu, Jawahar; Li, Jason; Klijn, Christiaan; Piskol, Robert; Junttila, Melissa R.; Shaw, Andrey S.; Merchant, Mark; Chang, Matthew T.; Kirkpatrick, Donald S.; Malek, Shiva 分享 收藏
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